A revised view of the role of CaMKII in learning and memory

IF 21.2 1区医学 Q1 NEUROSCIENCES Nature neuroscience Pub Date : 2024-11-18 DOI:10.1038/s41593-024-01809-x

Karl Ulrich Bayer, Karl Peter Giese

引用次数: 0

Abstract

The Ca²⁺/calmodulin (CaM)-dependent protein kinase II (CaMKII) plays a fundamental role in learning and possibly also in memory. However, current mechanistic models require fundamental revision. CaMKII autophosphorylation at Thr286 (pThr286) does not provide the molecular basis for long-term memory, as long believed. Instead, pThr286 mediates the signal processing required for induction of several distinct forms of synaptic plasticity, including Hebbian long-term potentiation and depression and non-Hebbian behavioral timescale synaptic plasticity. We discuss (i) the molecular computations by which CaMKII supports these diverse plasticity mechanisms, (ii) alternative CaMKII mechanisms that may contribute to the maintenance phase of LTP and (iii) the relationship of these mechanisms to behavioral learning and memory.

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关于 CaMKII 在学习和记忆中的作用的新观点

Ca2+/钙调蛋白（CaM）依赖性蛋白激酶 II（CaMKII）在学习中扮演着重要角色，也可能在记忆中扮演着重要角色。然而，目前的机理模型需要从根本上加以修正。CaMKII在Thr286（pThr286）处的自身磷酸化并不像人们长期以来认为的那样为长期记忆提供分子基础。相反，pThr286 介导了诱导几种不同形式的突触可塑性所需的信号处理，包括希伯来长期延时和抑制以及非希伯来行为时标突触可塑性。我们将讨论：(i) CaMKII 支持这些不同可塑性机制的分子计算；(ii) 可能有助于 LTP 维持阶段的其他 CaMKII 机制；(iii) 这些机制与行为学习和记忆的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.

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