TEMPO‐Mediated Cross‐Dehydrogenative Coupling for the Synthesis of Bis(indolyl)methanes

IF 2.8 4区 化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-11-18 DOI:10.1002/ajoc.202400484
You-Qiang Guo, Long Liang, Zhen-Yu Wang, Xiang Wu, You-Gui Li
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Abstract

A TEMPO‐oxidized method has been developed for the synthesis of bis(indolyl)‐methane derivatives by the cross‐dehydrogenative coupling between C(sp3)–H of para‐cresol derivatives and C(sp2)‐H of indoles in moderate yields under aqueous conditions. This approach has significant advantages in avoiding prefunctionalization, using water as the solvent and tolerating various functional groups.
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TEMPO 介导的交叉脱氢偶联合成双(吲哚基)甲烷
通过对位甲酚衍生物的 C(sp3)-H与吲哚的 C(sp2)-H之间的交叉脱氢偶联,开发了一种 TEMPO 氧化法合成双(吲哚基)甲烷衍生物,在水溶液条件下产量适中。这种方法在避免预官能化、使用水作为溶剂和容忍各种官能团方面具有显著优势。
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
期刊最新文献
TEMPO‐Mediated Cross‐Dehydrogenative Coupling for the Synthesis of Bis(indolyl)methanes Front Cover: Pd-Monothiosquaramides: Efficient Catalysts for the Enantioselective Imine Reduction of Dihydro-β-Carbolines (Asian J. Org. Chem. 11/2024) Cover Feature: Diastereoselective Synthesis of Meso-1,2-Diarylethane-1,2-Diamines Via Sodium Reduction of Imidazolines (Asian J. Org. Chem. 11/2024) Front Cover: Direct In Situ Polymer Modification of Titania Nanomaterial Surfaces via UV-irradiated Radical Polymerization (Asian J. Org. Chem. 10/2024) Pd(0)/TPPMS‐Catalyzed Tsuji–Trost Type Cross‐Coupling of Allylic Alcohols with Organoboron Compounds in Water
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