Stimulation-Evoked Resonant Neural Activity in the Subthalamic Nucleus Is Modulated by Sleep.

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY Movement Disorders Pub Date : 2024-11-19 DOI:10.1002/mds.30063

Christoph Wiest, Thomas G Simpson, Alek Pogosyan, Harutomo Hasegawa, Shenghong He, Fernando Rodriguez Plazas, Laura Wehmeyer, Sahar Yassine, Xuanjun Guo, Rahul Shah, Anca Merla, Andrea Perera, Ahmed Raslan, Andrew O'Keeffe, Michael G Hart, Francesca Morgante, Erlick A Pereira, Keyoumars Ashkan, Huiling Tan

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Abstract

Background: Deep brain stimulation is a treatment for advanced Parkinson's disease and currently tuned to target motor symptoms during daytime. Parkinson's disease is associated with multiple nocturnal symptoms such as akinesia, insomnia, and sleep fragmentation, which may require adjustments of stimulation during sleep for best treatment outcome.

Objectives: There is a need for a robust biomarker to guide stimulation titration across sleep stages. This study aimed to investigate whether evoked resonant neural activity (ERNA) is modulated by sleep.

Methods: We recorded local field potentials from the subthalamic nucleus of four Parkinson's patients with externalized electrodes while applying single stimulation pulses to investigate the effect of sleep on ERNA.

Results: We found that ERNA features change with wakefulness and sleep stages and are correlated with canonical frequency bands and heart rate.

Conclusions: Given that ERNA modulates with sleep, it could be used as a robust marker for automatic stimulation titration during sleep. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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眼下核刺激诱发的共振神经活动受睡眠调节

背景：脑深部刺激是治疗晚期帕金森病的一种方法，目前主要针对白天的运动症状。帕金森病伴有多种夜间症状，如运动障碍、失眠和睡眠破碎，这可能需要在睡眠期间调整刺激以达到最佳治疗效果：目的：需要一种可靠的生物标志物来指导各睡眠阶段的刺激滴定。本研究旨在探讨诱发共振神经活动（ERNA）是否受睡眠调节：我们用外置电极记录了四名帕金森病患者的丘脑下核局部场电位，同时施加单次刺激脉冲，研究睡眠对ERNA的影响：结果：我们发现ERNA的特征随清醒和睡眠阶段而变化，并与典型频带和心率相关：结论：鉴于ERNA会随睡眠而变化，因此可将其作为睡眠期间自动刺激滴定的可靠标记。©2024年作者。运动障碍》由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.