Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial.
Simon Valayer, Marie Alexandre, Mélanie Prague, Abdoul Habib Beavogui, Seydou Doumbia, Mark Kieh, Brian Greenwood, Bailah Leigh, Marie Poupelin, Christine Schwimmer, Samba O Sow, Irina Maljkovic Berry, Jens H Kuhn, Daniela Fusco, Natasha Dubois Cauwelaert, Deborah Watson-Jones, Rodolphe Thiébaut, Yves Lévy, Yazdan Yazdanpanah, Laura Richert, Edouard Lhomme, Jamila Aboulhab, Michelle Aguirre-MacKenzie, Pauline Akoo, Esther Akpa, Robert Akpata, Sara Albert, Boni Maxime Ale, Serry Alimamy-Bangura, Pierre Andong, Benetta C. Andrews, Stephane Anoma, Negin Atri, Augustin Augier, Ken Awuondo, Ahidjo Ayouba, Moses Badio, Aminata Bagayoko, Abby Balde, Joséphine Balssa, Lamin Molecule Bangura, Kesha Barrington, Eric Barte de Saint Fare, Beth Baseler, Ali Bauder, Claire Bauduin, Luke Bawo, Abdoul Habib Beavogui, Michael Belson, Safaa Ben-Farhat, Marion Bererd, Nicolas Bernaud, Teedoh Beyslow, Neirade Biai, Jeanne Billioux, Shere Billouin-Frazier, Blandine Binachon, Julie Blie, Viki Bockstal, Patricia Boison, Fatorma Bolay, Aliou Boly, Rachael Elizabeth Bonawitz, Anne-Gaëlle Borg, Samuel Bosompem, Courtney Bozman, Tyler Brady, Sarah Browne, Ryan Bullis, Barbara Cagniard, Kelly Cahill, Yingyun Cai, Aissata Abdoulaye Camara, Aboubacar Keira Camara, Alseny Modet Camara, Antoine Campagne, Cécilia Campion, Alexandre Cantan, Jennifer Cash, Siew Pin Chai, Francois Chambelin, Michael Chea, Geneviève Chêne, Edouard Choi, Michelle Chouinard, Florence Chung, Lucy Chung, Séverine Ciancia, Papa Ndiaga Cisse, Elfrida Cline-Cole, Céline Colin, Beth-Ann Coller, Djélikan Siaka Conde, Katherine Cone, Katherine Cone, Laurie Connor, Nicholas Connor, Joseph Boye Cooper, Sandrine Couffin-Cardiergues, Fatoumata Coulibaly, Mariam Coulibaly, Page Crew, Sandrine Dabakuyo-Yonli, Djeneba Dabitao, Thierry Damerval, Bionca Davis, Gibrilla Fadlu Deen, Eline Dekeyster, Jean-François Delfraissy, Christelle Delmas, Mahamadou Diakite, Alpha Diallo, Fatoumata Abdoulaye Diallo, Mamadou Saliou Diallo, Ayouba Diarra, Samba Diarra, Oualy Diawara, Bonnie Dighero-Kemp, Samba Diop, Waly Diouf, Saurabh Dixit, Barry Djenabou, Laurie Doepel, Eric D’Ortenzio, Seydou Doumbia, Moussa Moise Doumbia, Macaya Douoguih, Nelson Dozier, Natasha Dubois Cauwelaert, Alain DuChêne, Michael Duvenhage, Risa Eckes, Elizabeth Elliott, Luisa Enria, Hélène Espérou, Cécile Etienne, Allison Eyler, Lawrence Fakoli, Mosoka Fallah, Marie-Alix Fauvel, Sylvain Faye, John Fayiah, Suzanne Fleck, Vemy Fofana, Karine Fouth Tchos, Kokulo Franklin, Daniela Fusco, Auguste Gaddah, Marylène Gaignet, Katherine Gallagher, Julie Gardner, Harrison Gichini, Julia Garcia Gozalbes, Greg Grandits, Maima Gray, Brian Greenwood, Nico Grobler, Robin Gross, Louis Grue, Birgit Grund, Oumar Guindo, Swati Gupta, Fadima Haidara, Benjamin Hamz, Emma Hancox, Jean-Christophe Hébert, Jenny Hendriks, Patricia Hensley, Lisa E Hensley, Betsey Herpin, Elisabeth Higgs, Trudi Hilton, Mickael Hneino, Tracey-Ann Höeltermann, Horace Preston Holley, Marie Hoover, Natasha Howard, Melissa Hughes, Dicko Ilo, Skip Irvine, David Ishola, Yvonne Jato, Madison Joe, Melvin Johnson, Aboubacar Sidiki Kaba, Jonathan Kagan, Kade Kallon, Michael Kamara, Myriam Kante, Judith Katoudi, Cheick Mohamed Keita, Sakoba Keita, Seykou Keita, Stephen B. Kennedy, Babajide Keshinro, Hassan Kiawu, Mark Kieh, Brent Killinger, Moumouni Kinda, Matthew Kirchoff, Gregory Kocher, Mamoudou Kodio, Brian Kohn, Lamine Koivogui, Richard Kojan, Cece Francis Koli, Jacques Seraphin Koli, David Kollie, Stacy Kopka, Bockarie Koroma, Dickens Kowuor, Catherine Kpayieli-Freeman, Liane Kwast, Christine Lacabaratz, Boris Lacarra, Laurie Lambert, Courtney Lambeth, Solange Lancrey-javal, H. Clifford Lane, Shadrach Langba, Bolarinde Lawal, Andrew Wen-Tseng Lee, Shona Lee, Shelley Lees, Annabelle Lefevre, Bailah Leigh, Frederic Lemarcis, Yves Lévy, Claire Levy-Marchal, Maarten Leyssen, Edouard Lhomme, Janie Liang, Mameni Linga, Ken Liu, Brett Lowe, Julia Lysander, Ibrah Mahamadou, Irina Maljkovic-Berry, Marvington Mambiah, Daniela Manno, Jonathan Marchand, Lindsay Marron, Moses B.F. Massaquoi, Laure Masson, Charly Matard, Steven Mazur, John McCullough, Katherine McFadyen, Chelsea McLean, Noémie Mercier, Pauline Michavila, Tracey Miller, Niouma Pascal Millimouno, Alejandra Miranda, Soumaya Mohamed, Tom Mooney, Dally Muamba, James Mulbah, Rita Lukoo Ndamenyaa, James Neaton, Désiré Neboua, Micki Nelson, Kevin Newell, Vinh-kim Nguyen, Yusupha Njie, Wissedi Njoh, Anna Novotney-Barry, Matthew Onorato, Uma Onwuchekwa, Susan Orsega, Inmaculada Ortega-Perez, Cynthia Osborne, Tuda Otieno, Davy Oulaï, Sushma Patel, Danielle Peart, Martine Peeters, James Pettitt, Nathan Peiffer-Smadja, Robert Phillips, Jerome Pierson, Peter Piot, Micheal Piziali, Stéphany Pong, Elena Postnikova, Calvin Proffitt, Alexandre Quach, Sinead Quigley, Nadeeka Randunu, Laura Richert, Priscille Rivière, Cynthia Robinson, Céline Roy, Amy Falk Russell, Philip Sahr, Katy Saliba, Mohamed Samai, Sibiry Samake, Jen Sandrus, Ibrahim Sanogo, Yeya Sadio Sarro, Serge Sawadogo, Sani Sayadi, Maxime Schvartz, Christine Schwimmer, Fatou Secka, Heema Sharma, Denise Shelley, Bode Shobayo, Sophia Siddiqui, Jakub Simon, Shelly Simpson, Billy Muyisa Sivahera, Karen Slater, Mary Smolskis, Elizabeth Smout, Emily Snowden, Anne-Aygline Soutthiphong, Amadou Sow, Samba O. Sow, Ydrissa Sow, Michael Stirratt, Jeroen Stoop, Guna Subramaniam, Léa Surugue, Nathalie Swales, Sienneh Tamba, Chan Tang, Cheick Tangara, Milagritos D. Tapia, Julius Teahton, Jemee Tegli, Monique Termote, Guillaume Thaurignac, Rodolphe Thiebaut, Greg Thompson, John Tierney, Daniel Tindanbil, Abdoulaye Tour, Elvis Towalid, Stacey Traina, Awa Traore, Tijili Tyee, David Vallée, Renaud Vatrinet, Corine Vincent, Susan Vogel, Cedrick Wallet, Travis Warren, Deborah Watson-Jones, Wade Weaver, Deborah Wentworth, Cecelia Wesseh, Hilary Whitworth, Jimmy Whitworth, Aurelie Wiedemann, Wouter Willems, Barthalomew Wilson, Jayanthi Wolf, Alie Wurie, Delphine Yamadjako, Marcel Yaradouno, Quiawiah Yarmie, Yazdan Yazdanpanah, Shuiqing Yu, Zara Zeggani, Huanying Zhou
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Andrews, Stephane Anoma, Negin Atri, Augustin Augier, Ken Awuondo, Ahidjo Ayouba, Moses Badio, Aminata Bagayoko, Abby Balde, Joséphine Balssa, Lamin Molecule Bangura, Kesha Barrington, Eric Barte de Saint Fare, Beth Baseler, Ali Bauder, Claire Bauduin, Luke Bawo, Abdoul Habib Beavogui, Michael Belson, Safaa Ben-Farhat, Marion Bererd, Nicolas Bernaud, Teedoh Beyslow, Neirade Biai, Jeanne Billioux, Shere Billouin-Frazier, Blandine Binachon, Julie Blie, Viki Bockstal, Patricia Boison, Fatorma Bolay, Aliou Boly, Rachael Elizabeth Bonawitz, Anne-Gaëlle Borg, Samuel Bosompem, Courtney Bozman, Tyler Brady, Sarah Browne, Ryan Bullis, Barbara Cagniard, Kelly Cahill, Yingyun Cai, Aissata Abdoulaye Camara, Aboubacar Keira Camara, Alseny Modet Camara, Antoine Campagne, Cécilia Campion, Alexandre Cantan, Jennifer Cash, Siew Pin Chai, Francois Chambelin, Michael Chea, Geneviève Chêne, Edouard Choi, Michelle Chouinard, Florence Chung, Lucy Chung, Séverine Ciancia, Papa Ndiaga Cisse, Elfrida Cline-Cole, Céline Colin, Beth-Ann Coller, Djélikan Siaka Conde, Katherine Cone, Katherine Cone, Laurie Connor, Nicholas Connor, Joseph Boye Cooper, Sandrine Couffin-Cardiergues, Fatoumata Coulibaly, Mariam Coulibaly, Page Crew, Sandrine Dabakuyo-Yonli, Djeneba Dabitao, Thierry Damerval, Bionca Davis, Gibrilla Fadlu Deen, Eline Dekeyster, Jean-François Delfraissy, Christelle Delmas, Mahamadou Diakite, Alpha Diallo, Fatoumata Abdoulaye Diallo, Mamadou Saliou Diallo, Ayouba Diarra, Samba Diarra, Oualy Diawara, Bonnie Dighero-Kemp, Samba Diop, Waly Diouf, Saurabh Dixit, Barry Djenabou, Laurie Doepel, Eric D’Ortenzio, Seydou Doumbia, Moussa Moise Doumbia, Macaya Douoguih, Nelson Dozier, Natasha Dubois Cauwelaert, Alain DuChêne, Michael Duvenhage, Risa Eckes, Elizabeth Elliott, Luisa Enria, Hélène Espérou, Cécile Etienne, Allison Eyler, Lawrence Fakoli, Mosoka Fallah, Marie-Alix Fauvel, Sylvain Faye, John Fayiah, Suzanne Fleck, Vemy Fofana, Karine Fouth Tchos, Kokulo Franklin, Daniela Fusco, Auguste Gaddah, Marylène Gaignet, Katherine Gallagher, Julie Gardner, Harrison Gichini, Julia Garcia Gozalbes, Greg Grandits, Maima Gray, Brian Greenwood, Nico Grobler, Robin Gross, Louis Grue, Birgit Grund, Oumar Guindo, Swati Gupta, Fadima Haidara, Benjamin Hamz, Emma Hancox, Jean-Christophe Hébert, Jenny Hendriks, Patricia Hensley, Lisa E Hensley, Betsey Herpin, Elisabeth Higgs, Trudi Hilton, Mickael Hneino, Tracey-Ann Höeltermann, Horace Preston Holley, Marie Hoover, Natasha Howard, Melissa Hughes, Dicko Ilo, Skip Irvine, David Ishola, Yvonne Jato, Madison Joe, Melvin Johnson, Aboubacar Sidiki Kaba, Jonathan Kagan, Kade Kallon, Michael Kamara, Myriam Kante, Judith Katoudi, Cheick Mohamed Keita, Sakoba Keita, Seykou Keita, Stephen B. Kennedy, Babajide Keshinro, Hassan Kiawu, Mark Kieh, Brent Killinger, Moumouni Kinda, Matthew Kirchoff, Gregory Kocher, Mamoudou Kodio, Brian Kohn, Lamine Koivogui, Richard Kojan, Cece Francis Koli, Jacques Seraphin Koli, David Kollie, Stacy Kopka, Bockarie Koroma, Dickens Kowuor, Catherine Kpayieli-Freeman, Liane Kwast, Christine Lacabaratz, Boris Lacarra, Laurie Lambert, Courtney Lambeth, Solange Lancrey-javal, H. Clifford Lane, Shadrach Langba, Bolarinde Lawal, Andrew Wen-Tseng Lee, Shona Lee, Shelley Lees, Annabelle Lefevre, Bailah Leigh, Frederic Lemarcis, Yves Lévy, Claire Levy-Marchal, Maarten Leyssen, Edouard Lhomme, Janie Liang, Mameni Linga, Ken Liu, Brett Lowe, Julia Lysander, Ibrah Mahamadou, Irina Maljkovic-Berry, Marvington Mambiah, Daniela Manno, Jonathan Marchand, Lindsay Marron, Moses B.F. Massaquoi, Laure Masson, Charly Matard, Steven Mazur, John McCullough, Katherine McFadyen, Chelsea McLean, Noémie Mercier, Pauline Michavila, Tracey Miller, Niouma Pascal Millimouno, Alejandra Miranda, Soumaya Mohamed, Tom Mooney, Dally Muamba, James Mulbah, Rita Lukoo Ndamenyaa, James Neaton, Désiré Neboua, Micki Nelson, Kevin Newell, Vinh-kim Nguyen, Yusupha Njie, Wissedi Njoh, Anna Novotney-Barry, Matthew Onorato, Uma Onwuchekwa, Susan Orsega, Inmaculada Ortega-Perez, Cynthia Osborne, Tuda Otieno, Davy Oulaï, Sushma Patel, Danielle Peart, Martine Peeters, James Pettitt, Nathan Peiffer-Smadja, Robert Phillips, Jerome Pierson, Peter Piot, Micheal Piziali, Stéphany Pong, Elena Postnikova, Calvin Proffitt, Alexandre Quach, Sinead Quigley, Nadeeka Randunu, Laura Richert, Priscille Rivière, Cynthia Robinson, Céline Roy, Amy Falk Russell, Philip Sahr, Katy Saliba, Mohamed Samai, Sibiry Samake, Jen Sandrus, Ibrahim Sanogo, Yeya Sadio Sarro, Serge Sawadogo, Sani Sayadi, Maxime Schvartz, Christine Schwimmer, Fatou Secka, Heema Sharma, Denise Shelley, Bode Shobayo, Sophia Siddiqui, Jakub Simon, Shelly Simpson, Billy Muyisa Sivahera, Karen Slater, Mary Smolskis, Elizabeth Smout, Emily Snowden, Anne-Aygline Soutthiphong, Amadou Sow, Samba O. Sow, Ydrissa Sow, Michael Stirratt, Jeroen Stoop, Guna Subramaniam, Léa Surugue, Nathalie Swales, Sienneh Tamba, Chan Tang, Cheick Tangara, Milagritos D. Tapia, Julius Teahton, Jemee Tegli, Monique Termote, Guillaume Thaurignac, Rodolphe Thiebaut, Greg Thompson, John Tierney, Daniel Tindanbil, Abdoulaye Tour, Elvis Towalid, Stacey Traina, Awa Traore, Tijili Tyee, David Vallée, Renaud Vatrinet, Corine Vincent, Susan Vogel, Cedrick Wallet, Travis Warren, Deborah Watson-Jones, Wade Weaver, Deborah Wentworth, Cecelia Wesseh, Hilary Whitworth, Jimmy Whitworth, Aurelie Wiedemann, Wouter Willems, Barthalomew Wilson, Jayanthi Wolf, Alie Wurie, Delphine Yamadjako, Marcel Yaradouno, Quiawiah Yarmie, Yazdan Yazdanpanah, Shuiqing Yu, Zara Zeggani, Huanying Zhou","doi":"10.1080/22221751.2024.2432353","DOIUrl":null,"url":null,"abstract":"<p><p>rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination. Data from a large phase 2 randomized double-blind clinical trial (PREVAC) were used to evaluate waning of anti-Ebola virus (EBOV) glycoprotein (GP<sub>1,2</sub>) antibody concentrations after rVSVΔG-ZEBOV-GP or Ad26.ZEBOV, MVA-BN-Filo vaccination with linear mixed-effect regression models. After a post-vaccination peak, each vaccination strategy was associated with a decrease of anti-EBOV GP<sub>1,2</sub> antibody concentrations with distinct kinetics, highlighting a less-rapid decline in antibody levels after vaccination by rVSVΔG-ZEBOV-GP. One year after administration of the vaccine, antibody concentrations were higher in children compared to adults for both vaccines, although with different effect sizes: 1.74-fold higher concentrations (95% confidence interval [CI] [1.48; 2.02]) for children 12-17 years old to 3.10-fold higher concentrations (95% CI [2.58; 3.69]) for those 1-4 years old compared to adults for Ad26.ZEBOV, MVA-BN-Filo versus 1.36-fold (95% CI [1.12; 1.61]) to 1.41-fold (95% CI [1.21; 1.62]) higher than these values for adults, with relatively small changes from one age category of children to another, for rVSVΔG-ZEBOV-GP. Antibody concentrations also differed according to geographical location, pre-vaccination antibody concentration, and sex. In combination with knowledge on memory response, characterization of the major determinants of immune response durability of both vaccinations may guide future EVD control protocols.<b>Trial registration:</b> ClinicalTrials.gov identifier: NCT02876328.</p>","PeriodicalId":11602,"journal":{"name":"Emerging Microbes & Infections","volume":" ","pages":"2432353"},"PeriodicalIF":8.4000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632942/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Emerging Microbes & Infections","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/22221751.2024.2432353","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/9 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination. Data from a large phase 2 randomized double-blind clinical trial (PREVAC) were used to evaluate waning of anti-Ebola virus (EBOV) glycoprotein (GP1,2) antibody concentrations after rVSVΔG-ZEBOV-GP or Ad26.ZEBOV, MVA-BN-Filo vaccination with linear mixed-effect regression models. After a post-vaccination peak, each vaccination strategy was associated with a decrease of anti-EBOV GP1,2 antibody concentrations with distinct kinetics, highlighting a less-rapid decline in antibody levels after vaccination by rVSVΔG-ZEBOV-GP. One year after administration of the vaccine, antibody concentrations were higher in children compared to adults for both vaccines, although with different effect sizes: 1.74-fold higher concentrations (95% confidence interval [CI] [1.48; 2.02]) for children 12-17 years old to 3.10-fold higher concentrations (95% CI [2.58; 3.69]) for those 1-4 years old compared to adults for Ad26.ZEBOV, MVA-BN-Filo versus 1.36-fold (95% CI [1.12; 1.61]) to 1.41-fold (95% CI [1.21; 1.62]) higher than these values for adults, with relatively small changes from one age category of children to another, for rVSVΔG-ZEBOV-GP. Antibody concentrations also differed according to geographical location, pre-vaccination antibody concentration, and sex. In combination with knowledge on memory response, characterization of the major determinants of immune response durability of both vaccinations may guide future EVD control protocols.Trial registration: ClinicalTrials.gov identifier: NCT02876328.
期刊介绍：
Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses.
The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries.
This journal addresses topics of critical biological and clinical importance, including but not limited to:
- Epidemic surveillance
- Clinical manifestations
- Diagnosis and management
- Cellular and molecular pathogenesis
- Innate and acquired immune responses between emerging microbes and their hosts
- Drug discovery
- Vaccine development research
Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.
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