Cutaneous leishmaniasis: a neglected clinical manifestation among the tribal population in Nilambur, Kerala, India.

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-11-19 DOI:10.1093/trstmh/trae102

P A Fathima, Harish Kumar Shah, R S Aiswarya, P M Ajithlal, T V Shailaja, C Shubin, K J Reena, Prasanta Saini

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Abstract

Background: Different clinical manifestations of leishmaniasis (cutaneous and visceral) caused by Leishmania donovani have been reported from Kerala, India. Leishmania donovani causing cutaneous leishmaniasis (CL) (also called atypical CL [ACL]) is one of the major health concerns in the Western Ghats belt of the state.

Methods: Skin biopsies of 20 patients with suspected CL from Nilambur, Kerala, were processed for CL diagnosis during the period 2022-2023. Parasite species were characterized using Leishmania-specific Internal Transcribed Spacer-Ⅰ (ITS-Ⅰ) PCR and ITS-Ⅰ RFLP analysis.

Result: A total of 18 cases were confirmed to be CL and the parasite was identified as L. donovani.

Conclusion: These indigenous ACL (CL due to L. donovani) reports from the small foci of Nilambur reveal an emerging endemic zone of leishmaniasis in the Western Ghats.

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皮肤利什曼病：印度喀拉拉邦尼兰布尔部落人口中一种被忽视的临床表现。

背景：印度喀拉拉邦报告了由多诺万利什曼原虫引起的利什曼病（皮肤和内脏）的不同临床表现。由多诺万利什曼原虫引起的皮肤利什曼病（又称非典型利什曼病 [ACL]）是喀拉拉邦西高止山带的主要健康问题之一：方法：在 2022-2023 年期间，对喀拉拉邦尼兰布尔 20 名疑似利什曼病患者的皮肤活组织进行了处理，以诊断利什曼病。使用利什曼原虫特异性内部转录间隔物-Ⅰ（ITS-Ⅰ）PCR和ITS-ⅠRFLP分析确定寄生虫种类：结果：共有 18 个病例被确诊为 CL，寄生虫被鉴定为唐诺瓦尼氏菌：这些来自尼兰布尔小病灶的本地 ACL（由唐诺瓦尼龙引起的 CL）报告揭示了西高止山脉一个新出现的利什曼病流行区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transactions of The Royal Society of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.00

自引率

9.10%

发文量

115

审稿时长

4-8 weeks

期刊介绍： Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.