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An outbreak of cutaneous leishmaniasis from Belize in British Army personnel: a prospective clinical analysis. 英国陆军人员伯利兹皮肤利什曼病暴发:前瞻性临床分析
IF 1.5 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-09 DOI: 10.1093/trstmh/trag004
Ronan J Murphy, Mark S Bailey

Background: Cutaneous leishmaniasis (CL) is a vector-borne protozoal infection that causes skin lesions. Military personnel make up around 45% of UK cases. This study reports an outbreak of 35 soldiers with suspected CL from an exercise in Belize.

Methods: A prospective clinical analysis was conducted to characterise case presentations. Diagnostic results, time to cure and adverse effects were recorded.

Results: Thirty cases had laboratory-confirmed CL and three had suspected/resolved CL. Fifty percent of lesions were on the ear or face and 45% were on sites normally covered by clothing. Combined laboratory testing of skin biopsies confirmed a diagnosis in all cases. Ninety-three percent of species identified were Leishmania mexicana. Initial treatment was with miltefosine in 27 of the 30 confirmed cases. Five patients required second-line treatment with liposomal amphotericin B and one patient required third-line treatment with meglumine antimoniate.

Conclusions: This study characterised the largest outbreak of CL from Belize in British Army personnel for at least 25 y. Aspects of this outbreak were atypical and more research is required to investigate these. A simultaneous testing strategy with histology, microscopy and polymerase chain reaction of biopsy samples was sensitive. Treatment with miltefosine was less effective than expected in L. mexicana infection.

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引用次数: 0
Extreme weather effects on health services and communities in low and lower-middle income countries: a thematic systematic review. 极端天气对低收入和中低收入国家卫生服务和社区的影响:专题系统审查。
IF 1.5 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-09 DOI: 10.1093/trstmh/trag007
Julii Brainard, Yovitha Sedekia, Natalia R Jones, Michael Matte, Patrick Sunday, Deborah Watson-Jones, Daniel Dennis Mapemba, Severin A Kabakama, Edgar Mugema Mulogo, Moses Ntaro, Tran Thi Tuyet-Hanh, Paul R Hunter, Jo-Anne Geere

Most previous research about the dangers of extreme weather events was applicable to populations in high-income countries. Data summarising harms related to extreme weather events in low-income settings are lacking. A systematic review thematically summarising evidence about weather event-linked harms and responses in low- and lower-middle-income countries was conducted. Peer-reviewed and grey literature was systematically searched and selected. Data were extracted about harms, responses and outcomes relevant to six WHO building blocks of healthcare systems. Framework analysis was used to identify predominant themes related to harms, responses and the WHO building blocks. In total, 183 reports were included. Flooding and high winds were the most common types of extreme weather events documented. The main community experience themes identified were the displacement of populations and disruption. The main themes identified for health service delivery were vulnerability, disruption and resilience. Documented examples of resilience or recovery were far fewer for all six WHO healthcare system building blocks than descriptions of vulnerability and disruption. Extreme weather events can be highly disruptive and harmful to healthcare systems and communities in LMIC settings that are often already highly vulnerable.

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引用次数: 0
Facing pediatric snakebites unarmed: knowledge gaps and first-aid response challenges among parents in rural Sri Lanka. 面对手无寸铁的儿童蛇咬伤:斯里兰卡农村父母的知识差距和急救反应挑战。
IF 1.5 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-06 DOI: 10.1093/trstmh/traf147
Kavinda Dayasiri, Gihan Gunarathna, Indika Gawarammana, Shaluka Jayamanne

Background: Pediatric snakebites remain a neglected public health threat in rural Sri Lanka, where limited access to emergency care places children at heightened risk. Despite the high burden, there is a striking lack of research focused on strengthening preparedness in vulnerable communities.

Methods: A descriptive cross-sectional study was conducted in two high-incidence districts: Ampara and Polonnaruwa. Using cluster sampling, 518 parents of children aged <5 y completed structured, self-administered questionnaires assessing knowledge of snake identification and prehospital care interventions. Associations between sociodemographic variables and knowledge were analyzed using χ2 tests.

Results: Although 98.3% correctly identified the Indian cobra, only 34.6% recognized Russell's viper, and 82% misclassified the non-venomous rat snake as venomous. Prior first-aid training was significantly associated with improved knowledge on snake identification (p=0.02), symptoms and complications (p=0.00) and pre-hospital care (p=0.01). Misconceptions persisted: 29.3% believed antivenom should be given to all bite victims. Higher socioeconomic status was linked to better prehospital care knowledge (p=0.00), while lower parental education was associated with poorer knowledge (p=0.00). Personal or household snakebite experience showed no significant association (p>0.05).

Conclusions: Despite high exposure risk, caregiver preparedness is low. Community-based education targeting high-risk families is urgently needed to reduce preventable pediatric snakebite morbidity and mortality.

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引用次数: 0
Diseases of 'warm temperaments': a modern perspective on Dr Hother McCormack Hanschell's 'On the influence of race in venereal disease' and the legacies of colonialism and scientific racism in tropical medicine. “暖性”疾病:从现代角度看霍瑟·麦科马克·汉舍尔博士的《论种族对性病的影响》,以及热带医学中的殖民主义和科学种族主义的遗产。
IF 1.5 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-06 DOI: 10.1093/trstmh/traf151
Sol Richardson

In 1925, Dr Hother McCormack Hanschell, then director of the venereal diseases clinic at the Seamen's Hospital in London, published a paper entitled 'On the influence of race in venereal disease' in Transactions of the Royal Society of Tropical Medicine and Hygiene. The aim of the study, in Hanschell's words, was to evaluate whether it was possible to 'detect any racial influence on the course of three venereal diseases (ulcus molle, gonorrhoea and syphilis) in the individual patient'. The paper presents a window into epidemiological research, discourses on colonial medicine, and biological theories based on racial essentialism prevalent in the early 20th century. The issues raised by this paper continue to have implications for practice and research in tropical medicine today.

{"title":"Diseases of 'warm temperaments': a modern perspective on Dr Hother McCormack Hanschell's 'On the influence of race in venereal disease' and the legacies of colonialism and scientific racism in tropical medicine.","authors":"Sol Richardson","doi":"10.1093/trstmh/traf151","DOIUrl":"https://doi.org/10.1093/trstmh/traf151","url":null,"abstract":"<p><p>In 1925, Dr Hother McCormack Hanschell, then director of the venereal diseases clinic at the Seamen's Hospital in London, published a paper entitled 'On the influence of race in venereal disease' in Transactions of the Royal Society of Tropical Medicine and Hygiene. The aim of the study, in Hanschell's words, was to evaluate whether it was possible to 'detect any racial influence on the course of three venereal diseases (ulcus molle, gonorrhoea and syphilis) in the individual patient'. The paper presents a window into epidemiological research, discourses on colonial medicine, and biological theories based on racial essentialism prevalent in the early 20th century. The issues raised by this paper continue to have implications for practice and research in tropical medicine today.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of hepatitis B virus surface gene mutations from Huzhou, eastern China. 湖州地区乙型肝炎病毒表面基因突变特征分析
IF 1.5 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-05 DOI: 10.1093/trstmh/trag001
Zihan Han, Fang Jin, Peng Luo, Dongli Li, Jianfeng Zhong, Zhaowei Tong, Fuchu Qian

Background: Amino acid (AA) substitutions in the hepatitis B virus (HBV) S gene are key drivers of diagnostic evasion, vaccine breakthrough infections and immune escape. Understanding regional mutation profiles is essential for public health intervention. This study aimed to characterize the prevalence and mutation patterns of the HBV S gene in eastern China.

Methods: In this cross-sectional study, serum samples from 244 patients with chronic HBV infection were collected. The S gene was amplified by nested polymerase chain reaction, followed by genotyping and AA substitution analysis using Geno2pheno HBV and the MEGA 11.0 platform. Concurrent laboratory assessments included serological (HBsAg, anti-HBs, HBeAg, anti-HBe), biochemical (ALT, AST) and virological (HBV DNA load).

Results: Mutation frequencies were 38.9% (95/244) in the major hydrophilic region and 22.1% (54/244) in the α determinant. Hotspot mutations included Q101R/K, I/T126S/T/V/A/I, Q129H/R, M133L/T, G145R/T/A and F/Y161Y/F. Notably, AA substitutions including L104F/W, T113S, T123P, I126V and G145T differed from previously reported variants. Additional novel mutation sites P105L, S117R/T and W156L were identified. The I92T, Y100C/S and I126S/T/V mutations showed specific associations with genotype C, whereas Y161F was exclusively detected in genotype B.

Conclusions: This study documents a high frequency of S gene mutations within critical immune regions among chronic HBV-infected patients in eastern China, alongside novel mutation sites and distinct genotype-dependent patterns. HBV genotype and age were independently associated with S gene mutation. These findings provide a molecular basis for optimizing regional diagnostic strategies and future vaccine design.

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引用次数: 0
Deep venous thrombosis due to Wuchereria bancrofti-induced reactive hypereosinophilia syndrome: a case report. 班氏乌氏杆菌引起的反应性嗜酸性细胞增多症引起的深静脉血栓1例。
IF 1.5 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-05 DOI: 10.1093/trstmh/trag002
Rohan Nitin Pai, Sandeep Rao Kordcal, Ashutosh Singh, Manish Soneja

We report a case of hypereosinophilia syndrome (HES) due to Wuchereria bancrofti infection presenting with a deep venous thrombosis in a previously healthy adult male. The patient presented with a 3-mo history of low-grade intermittent fever and an acute onset of swelling of the left lower limb. Laboratory investigations revealed marked eosinophilia with a peak absolute eosinophil count of 8194 cells/µl and ultrasound evidence of extensive left iliofemoro-popliteal thrombosis. Our workup for secondary causes confirmed W. bancrofti antigen positivity, following which antiparasitic therapy was promptly initiated and a reduction in eosinophil count was noted. Our case highlights the importance of recognition of filariasis as a cause of reactive HES in an endemic region and recognising the thromboembolic complications that may arise from it.

我们报告一例高嗜酸性粒细胞综合征(HES)由于班氏乌氏杆菌感染呈现深静脉血栓形成在一个以前健康的成年男性。患者表现为3个月的低度间歇发热史和左下肢急性肿胀。实验室检查显示明显的嗜酸性粒细胞增多,嗜酸性粒细胞绝对计数峰值为8194个细胞/µl,超声证据显示广泛的左髂股腘窝血栓形成。我们对继发性原因的检查证实了W. bancrofti抗原阳性,随后立即开始抗寄生虫治疗,并注意到嗜酸性粒细胞计数减少。我们的病例强调了认识到丝虫病是流行地区反应性HES的原因的重要性,并认识到可能由此产生的血栓栓塞并发症。
{"title":"Deep venous thrombosis due to Wuchereria bancrofti-induced reactive hypereosinophilia syndrome: a case report.","authors":"Rohan Nitin Pai, Sandeep Rao Kordcal, Ashutosh Singh, Manish Soneja","doi":"10.1093/trstmh/trag002","DOIUrl":"https://doi.org/10.1093/trstmh/trag002","url":null,"abstract":"<p><p>We report a case of hypereosinophilia syndrome (HES) due to Wuchereria bancrofti infection presenting with a deep venous thrombosis in a previously healthy adult male. The patient presented with a 3-mo history of low-grade intermittent fever and an acute onset of swelling of the left lower limb. Laboratory investigations revealed marked eosinophilia with a peak absolute eosinophil count of 8194 cells/µl and ultrasound evidence of extensive left iliofemoro-popliteal thrombosis. Our workup for secondary causes confirmed W. bancrofti antigen positivity, following which antiparasitic therapy was promptly initiated and a reduction in eosinophil count was noted. Our case highlights the importance of recognition of filariasis as a cause of reactive HES in an endemic region and recognising the thromboembolic complications that may arise from it.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic health manifestations following hump-nosed pit viper (Hypnale spp.) bites: an authenticated case series. 驼峰鼻蝮蛇(Hypnale spp.)咬伤后的慢性健康表现:一个经过验证的病例系列。
IF 1.5 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-04 DOI: 10.1093/trstmh/traf148
R M M K Namal Rathnayaka, P E Anusha Nishanthi Ranathunga, S A M Kularatne

Background: Hump-nosed pit vipers (genus Hypnale) are the most common cause of venomous snakebites in Sri Lanka, accounting for more than one-third of all snakebites, as they are widely distributed throughout the country. It is a highly medically important snake in Sri Lanka. Even though several life-threatening complications, including venom-induced consumption coagulopathy, acute kidney injury, venom-induced thrombotic microangiopathy and cardiac effects, are reported following their bites, no antivenom is currently available for Hypnale - envenomed patients either in Sri Lanka or India. Apart from the acute manifestations of snakebites, chronic health effects have rarely been described in the literature.

Methods: A case series of 11 patients who developed long-term health effects following hump-nosed pit viper bites was prospectively studied at the Teaching Hospital, Ratnapura, Sri Lanka, from June 2015 to May 2021. Data on clinical presentation, examination findings, investigations, management and two-year follow-up were collected.

Results: This case series describes some of the chronic health manifestations following hump-nosed pit viper bites in 11 patients, including chronic kidney disease, fasciotomy-related injuries, musculoskeletal disabilities and pulmonary effects.

Conclusion: Hump-nosed pit viper bites can cause severe long-term sequelae that require follow-up. Physicians should be aware of these manifestations when managing patients and this case series highlights the need for an effective antivenom for Hypnale bites.

背景:驼鼻蝮蛇(Hypnale属)是斯里兰卡毒蛇咬伤的最常见原因,占所有毒蛇咬伤的三分之一以上,因为它们广泛分布在全国各地。在斯里兰卡,这是一种非常重要的医学蛇。尽管在被毒蛇咬伤后报告了几种危及生命的并发症,包括毒蛇引起的食用性凝血功能障碍、急性肾损伤、毒蛇引起的血栓性微血管病和心脏影响,但在斯里兰卡或印度,目前尚无抗蛇毒血清可用于被毒蛇咬伤的患者。除了蛇咬伤的急性表现外,文献中很少描述蛇咬伤对健康的慢性影响。方法:前瞻性研究2015年6月至2021年5月斯里兰卡拉特纳普拉教学医院11例驼鼻蝮蛇咬伤后出现长期健康影响的病例系列。收集了临床表现、检查结果、调查、管理和两年随访的资料。结果:本病例系列描述了11例驼鼻蝮蛇咬伤后的一些慢性健康表现,包括慢性肾病、筋膜切断术相关损伤、肌肉骨骼残疾和肺部影响。结论:驼鼻蝮蛇咬伤可引起严重的长期后遗症,需随访。医生在管理患者时应该意识到这些表现,本病例系列强调需要有效的抗蛇毒血清治疗Hypnale咬伤。
{"title":"Chronic health manifestations following hump-nosed pit viper (Hypnale spp.) bites: an authenticated case series.","authors":"R M M K Namal Rathnayaka, P E Anusha Nishanthi Ranathunga, S A M Kularatne","doi":"10.1093/trstmh/traf148","DOIUrl":"https://doi.org/10.1093/trstmh/traf148","url":null,"abstract":"<p><strong>Background: </strong>Hump-nosed pit vipers (genus Hypnale) are the most common cause of venomous snakebites in Sri Lanka, accounting for more than one-third of all snakebites, as they are widely distributed throughout the country. It is a highly medically important snake in Sri Lanka. Even though several life-threatening complications, including venom-induced consumption coagulopathy, acute kidney injury, venom-induced thrombotic microangiopathy and cardiac effects, are reported following their bites, no antivenom is currently available for Hypnale - envenomed patients either in Sri Lanka or India. Apart from the acute manifestations of snakebites, chronic health effects have rarely been described in the literature.</p><p><strong>Methods: </strong>A case series of 11 patients who developed long-term health effects following hump-nosed pit viper bites was prospectively studied at the Teaching Hospital, Ratnapura, Sri Lanka, from June 2015 to May 2021. Data on clinical presentation, examination findings, investigations, management and two-year follow-up were collected.</p><p><strong>Results: </strong>This case series describes some of the chronic health manifestations following hump-nosed pit viper bites in 11 patients, including chronic kidney disease, fasciotomy-related injuries, musculoskeletal disabilities and pulmonary effects.</p><p><strong>Conclusion: </strong>Hump-nosed pit viper bites can cause severe long-term sequelae that require follow-up. Physicians should be aware of these manifestations when managing patients and this case series highlights the need for an effective antivenom for Hypnale bites.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A qualitative study assessing the acceptability of a multi-agent AI Chatbot for providing HIV and mental health support among men who have sex with men and transgender women in KwaZulu-Natal, South Africa. 一项定性研究评估了南非夸祖鲁-纳塔尔省男男性行为者和变性妇女对多agent AI聊天机器人提供艾滋病毒和心理健康支持的可接受性。
IF 1.5 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-02 DOI: 10.1093/trstmh/traf143
Hilton Humphries, Lindani Msimango, Zimasa Tshawe, Natasha Gcelu, Kurt Ferreira, Jacqueline Pienaar, Elise M van der Elst, Danielle Giovenco, Don Operario, Eduard J Sanders, Alastair van Heerden

Background: Transgender women (TGW) and men who have sex with men (MSM) are disproportionately affected by human immunodeficiency virus (HIV) and mental health challenges. Mental well-being influences uptake and adherence to HIV prevention and treatment. However, gaps in mental health service delivery present challenges for scalability in public health systems. Artificial intelligence (AI)-driven chatbots may offer a novel, scalable solution to expand access to mental health support.

Methods: This qualitative study was conducted at the Aurum POP INN clinic in Pietermaritzburg, KwaZulu-Natal. A multi-agent AI chatbot, designed to simulate supportive counselling based on the Inuka model, was piloted with TGW and MSM. Ten participants engaged in in-depth interviews after interacting with the chatbot. An additional 34 participants experienced both chatbot and in-person counselling through a randomised crossover design and then participated in four focus group discussions. The Unified Theory of Acceptance and Use of Technology and the Acceptability of Healthcare Interventions Framework guided the analysis.

Results: The chatbot was generally acceptable, with participants valuing its privacy, convenience and human-like interaction. Acceptability was enhanced by associations with modernity and anonymity. Trust, usability and accessibility improved engagement. Key barriers included slow response times, limited rapport and repetitive messaging.

Conclusions: AI chatbots offer a promising, scalable approach to supporting mental health among key populations in HIV care.

背景:跨性别妇女(TGW)和男男性行为者(MSM)不成比例地受到人类免疫缺陷病毒(HIV)和精神健康挑战的影响。心理健康影响艾滋病毒预防和治疗的接受和坚持。然而,精神卫生服务提供方面的差距对公共卫生系统的可扩展性提出了挑战。人工智能(AI)驱动的聊天机器人可能会提供一种新颖的、可扩展的解决方案,以扩大获得心理健康支持的机会。方法:本定性研究在夸祖鲁-纳塔尔省彼得马里茨堡的Aurum POP INN诊所进行。一个多代理人工智能聊天机器人,设计用来模拟基于Inuka模型的支持性咨询,在TGW和MSM中进行了试点。10名参与者在与聊天机器人互动后进行了深度采访。另外34名参与者通过随机交叉设计体验了聊天机器人和面对面的咨询,然后参加了四次焦点小组讨论。技术接受与使用统一理论和卫生保健干预可接受性框架指导了分析。结果:聊天机器人总体上是可以接受的,参与者重视它的隐私性、便利性和类似人类的互动。可接受性通过与现代性和匿名性的联系而增强。信任、可用性和可访问性提高了用户粘性。主要障碍包括反应时间慢、关系有限和信息重复。结论:人工智能聊天机器人为支持艾滋病毒护理中关键人群的心理健康提供了一种有前途的、可扩展的方法。
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引用次数: 0
Leprosy in India: challenges, advances and the path to eradication. 印度的麻风病:挑战、进展和根除之路。
IF 1.5 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-02 DOI: 10.1093/trstmh/traf107
Sayanti Chatterjee, Pragya Santra, Riddhi Paul, Asesh Banerjee, Prabuddha Gupta

The fight against leprosy has entered the crucial final phase in India, with the government's announcement of a national plan for zero transmission by 2027. Presently, leprosy has pockets of high prevalence in India and unknown transmission chains. At this juncture, we focus on essential aspects of this disease to help everyone understand the basics of the causative agent, disease prognosis, epidemiology, disease-associated societal implications and prevention strategies. Our endeavour aims to inspire novel concepts among early career researchers for combating leprosy.

印度防治麻风病的斗争已进入关键的最后阶段,政府宣布了到2027年实现零传播的国家计划。目前,麻风病在印度有高流行率和未知传播链。在这个关键时刻,我们专注于这种疾病的基本方面,以帮助每个人了解病原体,疾病预后,流行病学,疾病相关的社会影响和预防策略的基础知识。我们的努力旨在激发早期职业研究人员对抗麻风病的新概念。
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引用次数: 0
Inhibition of butyrylcholinesterase in a population exposed to insecticides during a campaign against Aedes aegypti. 在对抗埃及伊蚊的运动中,暴露于杀虫剂的种群中丁基胆碱酯酶的抑制作用。
IF 1.5 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-02-02 DOI: 10.1093/trstmh/traf108
Luis A Chávez-Almazán, Hugo A Saldarriaga-Noreña, Diana Garibo-Ruiz, Ma Concepción Arcos-Cuevas

Background: Chemical control remains a widely used strategy to reduce morbidity from vector-borne diseases such as dengue. However, the potential health risks to exposed populations necessitates ongoing monitoring, particularly due to the toxicity and volume of insecticides employed.

Methods: This study assessed butyrylcholinesterase activity in residents of a city in southern Mexico during distinct periods of exposure to carbamate and organophosphate insecticides.

Results: A statistically significant inhibition of enzymatic activity was observed during the rainy season, which coincided with an increase in insecticide application.

Conclusions: These findings highlight the need for public health authorities to implement preventative measures aimed at minimizing poisoning risks associated with vector control activities.

背景:化学控制仍然是一种广泛使用的策略,以减少媒介传播的疾病,如登革热的发病率。然而,暴露人群的潜在健康风险需要持续监测,特别是考虑到所使用杀虫剂的毒性和数量。方法:本研究评估了墨西哥南部一个城市居民在暴露于氨基甲酸酯和有机磷杀虫剂的不同时期的丁基胆碱酯酶活性。结果:在雨季观察到酶活性有统计学意义的抑制,这与杀虫剂施用的增加相一致。结论:这些发现突出表明,公共卫生当局需要采取预防措施,尽量减少与病媒控制活动相关的中毒风险。
{"title":"Inhibition of butyrylcholinesterase in a population exposed to insecticides during a campaign against Aedes aegypti.","authors":"Luis A Chávez-Almazán, Hugo A Saldarriaga-Noreña, Diana Garibo-Ruiz, Ma Concepción Arcos-Cuevas","doi":"10.1093/trstmh/traf108","DOIUrl":"10.1093/trstmh/traf108","url":null,"abstract":"<p><strong>Background: </strong>Chemical control remains a widely used strategy to reduce morbidity from vector-borne diseases such as dengue. However, the potential health risks to exposed populations necessitates ongoing monitoring, particularly due to the toxicity and volume of insecticides employed.</p><p><strong>Methods: </strong>This study assessed butyrylcholinesterase activity in residents of a city in southern Mexico during distinct periods of exposure to carbamate and organophosphate insecticides.</p><p><strong>Results: </strong>A statistically significant inhibition of enzymatic activity was observed during the rainy season, which coincided with an increase in insecticide application.</p><p><strong>Conclusions: </strong>These findings highlight the need for public health authorities to implement preventative measures aimed at minimizing poisoning risks associated with vector control activities.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"154-156"},"PeriodicalIF":1.5,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Transactions of The Royal Society of Tropical Medicine and Hygiene
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