Antimicrobial polyketides from an endophytic fungus Arcopilus aureus HJ-7 from Ardisia mamillata Hance.

IF 1.9 3区 化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2024-11-19 DOI:10.1080/14786419.2024.2429119
Li-Qi Liang, Xian-Hua He, Chun-Yan Wei, Jing-Xian Zhao, Qian Wu, Min Liang, Jun Li, Yan Luo, Wei-Feng Xu, Rui-Yun Yang
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Abstract

Eleven polyketide derivatives, including two new compounds, xanthoradone D (1) and arisochromophilone (2), were isolated from Arcopilus aureus HJ-7, a Chinese medicinal plant Ardisia mamillata Hance-associated fungus. Their structures were elucidated on the basis of spectroscopic analysis and ECD (Electronic Circular Dichroism) calculations. The antibacterial and antifungal activities of the compounds were evaluated. Compound 1 showed the significant inhibitory activity against Staphylococcus aureus and Xanthomonas axonopodis pv. citri (Hasse) Dye with the MIC (Minimum Inhibitory Concentration) value of 6.25 μg/mL, and 1 also showed strong antifungal activities against Cochliobolus miyabeanus and Ceratocystis paradoxa with the MIC value of 3.125 μg/mL.

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来自 Ardisia mamillata Hance 的内生真菌 Arcopilus aureus HJ-7 的抗菌多酮。
研究人员从中国药用植物黄花蒿的伴生真菌 Arcopilus aureus HJ-7 中分离出 11 种多酮类衍生物,其中包括两种新化合物黄腐酮 D(1)和 Arisochromophilone(2)。通过光谱分析和电子圆二色性(ECD)计算,阐明了它们的结构。评估了这些化合物的抗菌和抗真菌活性。化合物 1 对金黄色葡萄球菌和 Axonopodis Xanthomonas pv. citri (Hasse) Dye 具有明显的抑制活性,最低抑菌浓度为 6.25 μg/mL;化合物 1 还对 Cochliobolus miyabeanus 和 Ceratocystis paradoxa 具有很强的抗真菌活性,最低抑菌浓度为 3.125 μg/mL。
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来源期刊
Natural Product Research
Natural Product Research 化学-医药化学
CiteScore
5.10
自引率
9.10%
发文量
605
审稿时长
2.1 months
期刊介绍: The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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