{"title":"Radiographic and tomographic findings of excretory urography of avian kidneys after induced nephropathy in broiler chicken as a model.","authors":"Mahsa Zangisheh, Majid Masoudifard, Seyed Ahmad Madani, Alireza Vajhi, Hamideh Hasannejhad, Ameneh Ghojoghi","doi":"10.1002/vms3.70036","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Although kidney diseases have a high prevalence, initial recognition and diagnosis of renal disease are complicated in avian medicine.</p><p><strong>Objective: </strong>The aim of this study is to assess the intraosseous excretory urography (IOEU) in order to introduce a new method for evaluation of kidney's function in broilers as a primary model of birds.</p><p><strong>Methods: </strong>A total of 10 male broiler chickens at the age of 20 days were included and evaluated with plain and serial post-contrast radiography and computed tomography (CT) scan to check the time and concentration of the contrast media (CM) passage from the kidney. In the next step, after the nephropathy induction with gentamicin, plain and serial post-contrast radiography and CT scan were repeated. After the necropsy, kidney samples were sent for histopathology evaluation, and statistical analysis of data obtained from image analysis was conducted.</p><p><strong>Results: </strong>After nephropathy induction, all of the chickens exhibited increase in kidney size and in histopathological evaluation, all the samples (30 of 30) showed severe tubular necrosis and mild glomerulopathy. In the IOEU, the average time to create the maximum concentration of CM, the average time to decrease the CM concentration from the kidney and the time of the complete clearance of CM indicated a significant incensement after nephropathy compared to the time before it.</p><p><strong>Conclusion: </strong>Intraosseous excretory urography (IOEU) is a safe contrast imaging modality and can be useful in the assessment of the urinary system in chickens to check the changes in kidney size and function.</p>","PeriodicalId":23543,"journal":{"name":"Veterinary Medicine and Science","volume":"11 1","pages":"e70036"},"PeriodicalIF":1.8000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574877/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Medicine and Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1002/vms3.70036","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Although kidney diseases have a high prevalence, initial recognition and diagnosis of renal disease are complicated in avian medicine.
Objective: The aim of this study is to assess the intraosseous excretory urography (IOEU) in order to introduce a new method for evaluation of kidney's function in broilers as a primary model of birds.
Methods: A total of 10 male broiler chickens at the age of 20 days were included and evaluated with plain and serial post-contrast radiography and computed tomography (CT) scan to check the time and concentration of the contrast media (CM) passage from the kidney. In the next step, after the nephropathy induction with gentamicin, plain and serial post-contrast radiography and CT scan were repeated. After the necropsy, kidney samples were sent for histopathology evaluation, and statistical analysis of data obtained from image analysis was conducted.
Results: After nephropathy induction, all of the chickens exhibited increase in kidney size and in histopathological evaluation, all the samples (30 of 30) showed severe tubular necrosis and mild glomerulopathy. In the IOEU, the average time to create the maximum concentration of CM, the average time to decrease the CM concentration from the kidney and the time of the complete clearance of CM indicated a significant incensement after nephropathy compared to the time before it.
Conclusion: Intraosseous excretory urography (IOEU) is a safe contrast imaging modality and can be useful in the assessment of the urinary system in chickens to check the changes in kidney size and function.
背景虽然肾脏疾病的发病率很高，但在禽类医学中，肾脏疾病的初步识别和诊断却很复杂：本研究的目的是评估骨内排泄性尿路造影术（IOEU），以便引入一种新方法来评估作为鸟类初级模型的肉鸡的肾功能：方法：选取 10 只 20 日龄的雄性肉鸡，通过普通和连续的造影后射线照相术和计算机断层扫描（CT）对其进行评估，以检查造影剂（CM）从肾脏排出的时间和浓度。下一步，在使用庆大霉素诱导肾病后，再次进行普通和序列对比后射线照相术和计算机断层扫描。解剖后，将肾脏样本送去进行组织病理学评估，并对图像分析获得的数据进行统计分析：结果：诱导肾病后，所有鸡的肾脏体积都增大了，在组织病理学评估中，所有样本（30 份中的 30 份）都显示出严重的肾小管坏死和轻微的肾小球病变。在 IOEU 中，产生最大 CM 浓度的平均时间、降低肾脏中 CM 浓度的平均时间以及 CM 完全清除的时间都表明，肾病后的 CM 浓度比肾病前显著增加：结论：骨内排泄性尿路造影（IOEU）是一种安全的造影方式，可用于评估小鸡的泌尿系统，检查肾脏大小和功能的变化。
期刊介绍：
Veterinary Medicine and Science is the peer-reviewed journal for rapid dissemination of research in all areas of veterinary medicine and science. The journal aims to serve the research community by providing a vehicle for authors wishing to publish interesting and high quality work in both fundamental and clinical veterinary medicine and science.
Veterinary Medicine and Science publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.
We aim to be a truly global forum for high-quality research in veterinary medicine and science, and believe that the best research should be published and made widely accessible as quickly as possible. Veterinary Medicine and Science publishes papers submitted directly to the journal and those referred from a select group of prestigious journals published by Wiley-Blackwell.
Veterinary Medicine and Science is a Wiley Open Access journal, one of a new series of peer-reviewed titles publishing quality research with speed and efficiency. For further information visit the Wiley Open Access website.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
