Association between exposure to per- and polyfluoroalkyl substances and missed miscarriage: A hospital-based case-control study in Shanghai, China

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2024-11-16 DOI:10.1016/j.etap.2024.104589

Beiying Wang, Wei Hong, Zhiping Wu, Xiaocui Li

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Abstract

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants linked to reproductive disruptions. This study investigated the relationship between PFAS exposure and missed miscarriage in a hospital-based, case-control study in Shanghai, China. There were 393 women in our research, including 198 cases and 195 controls. Concentrations of 30 PFAS in plasma were quantified using HPLC-MS/MS, and 15 PFAS were detected at a rate greater than 90 percent. PFOA, L-PFOS, and PFOS isomers were significantly higher in the cases than those in the controls. 13 PFAS showed significant positive associations with miscarriage risk after adjustment for confounders, particularly PFOA (OR: 2.99, 95 % CI: 1.96–4.68) and various PFOS isomers. BKMR analysis confirmed higher overall PFAS levels were associated with increased miscarriage risk. These findings highlight the potential reproductive toxicity of PFAS and underscore the need for further investigations and regulatory actions to mitigate PFAS exposure in pregnant women.

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接触全氟和多氟烷基物质与流产漏诊之间的关系：中国上海医院病例对照研究》。

全氟和多氟烷基物质（PFAS）是与生殖干扰有关的持久性环境污染物。本研究在中国上海进行了一项基于医院的病例对照研究，调查了PFAS暴露与漏发流产之间的关系。研究共涉及 393 名妇女，包括 198 例病例和 195 例对照。我们使用 HPLC-MS/MS 对血浆中 30 种 PFAS 的浓度进行了定量，其中 15 种 PFAS 的检出率超过 90%。病例中的 PFOA、L-PFOS 和 PFOS 异构体含量明显高于对照组。在对混杂因素进行调整后，13 种 PFAS 与流产风险呈显著正相关，尤其是 PFOA（OR：2.99，95% CI：1.96-4.68）和各种 PFOS 异构体。BKMR分析证实，PFAS总体水平越高，流产风险越大。这些发现凸显了全氟辛烷磺酸对生殖系统的潜在毒性，并强调有必要开展进一步调查和采取监管行动，以减少孕妇接触全氟辛烷磺酸的机会。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.