T. C. Xu, R. Luo, Z. X. Chen, J. Song, H. X. Cui, X. Hong, Y. L. Han, M. Bu, M. Wang
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引用次数: 0
Abstract
A series of novel lupeol-3-urea/thiourea derivatives were designed, synthesized and evaluated for their in vitro anticancer activity against human lung cancer A549, human hepatocellular carcinoma HepG2 and human breast cancer MCF-7 cell lines. The antitumor activities of all compounds were higher than that of parent Lupeol. Among them, lup-20(29)-en-3β-yl-piperazinecarboxylate-(2,4-fluorophenyl)urea showed the strongest antitumor activity against A549 cell lines, with an IC50 of 3.22 μM, which is tenfold than that of Lupeol. Therefore, lup-20(29)-en-3β-yl-piperazinecarboxylate-(2,4-fluorophenyl)urea can be used as a new lead compound for the development of more potent antitumor drugs.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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