{"title":"Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates","authors":"Leonie Mayer, Leonie M. Weskamm, Marylyn M. Addo","doi":"10.1038/s41392-024-02058-x","DOIUrl":null,"url":null,"abstract":"<p>In a recent study published in <i>Cell</i>, Mucker et al. demonstrated in a non-human primate (NHP) model of lethal mpox virus (MPXV) infection, that a novel mRNA-based vaccine, as compared to the standard-of-care modified vaccinia virus Ankara (MVA) vaccine, provides similar protective efficacy against lethality but superior efficacy against disease.<sup>1</sup> In the mRNA-vaccinated group, a reduction in the number of lesions and viremia was associated with both neutralizing and Fc-mediated antibody functionality.</p>","PeriodicalId":21766,"journal":{"name":"Signal Transduction and Targeted Therapy","volume":"3 1","pages":""},"PeriodicalIF":40.8000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Signal Transduction and Targeted Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41392-024-02058-x","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In a recent study published in Cell, Mucker et al. demonstrated in a non-human primate (NHP) model of lethal mpox virus (MPXV) infection, that a novel mRNA-based vaccine, as compared to the standard-of-care modified vaccinia virus Ankara (MVA) vaccine, provides similar protective efficacy against lethality but superior efficacy against disease.1 In the mRNA-vaccinated group, a reduction in the number of lesions and viremia was associated with both neutralizing and Fc-mediated antibody functionality.
期刊介绍：
Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy.
Scope: The journal covers research on major human diseases, including, but not limited to:
Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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