Association of maternal pyrethroid pesticides exposure during the whole pregnancy with neonate lipid metabolism: A Prospective Birth Cohort Study, Yunnan, China

Abstract

Dyslipidemias may emerge during the fetal period. However, the association between prenatal pyrethroid pesticides (PYRs) exposure and neonatal lipid metabolism remains uncertain. To explore the association of prenatal PYRs exposure and neonates’ lipid metabolism, pregnant women were recruited in rural Yunnan, China, and their urine samples in the first, second, and third trimester and their neonates’ cord blood samples were collected to obtain urinary PYRs metabolites (3PBA, 4F3PBA, and DBCA), cord blood TC, TG, HDL-C, LDL-C, and Non-HDL-C, AIP, CRI-I, CRI-II, AC, and LCI. We found the total PYRs detection during pregnancy was 99.6%. High-level DBCA in the first and third trimester and high-level 3PBA in the second trimester increased risks of high AIP. High-level ∑PYRs in the third trimester enhanced risks of high levels of TG, LDL-C, Non-HDL-C, AIP, and LCI. Repeated high-level 3PBA in two trimesters and above elevated risks of high levels of TG, LDL-C, CRI-I, AIP, AC, and LCI. Repeated high-level DBCA group in two trimesters and above increased the risk of high AIP. Repeated high ∑PYRs in three trimesters intensified risks of high levels of TC, LDL-C, Non-HDL-C, and AIP. Thus, our study suggests high PYRs exposure during the whole pregnancy may increase the risk of neonate abnormal lipid metabolism. The third trimester is the most sensitive window of high prenatal PYRs exposure. The adverse effects on neonate lipid metabolism increased as the increasing of trimesters repeated high-level PYRs exposure during pregnancy. Different kinds of PYRs exposure may induce different cord blood abnormal lipids.