Pub Date : 2025-03-20DOI: 10.1016/j.jhazmat.2025.137950
Wenjing Liu, Aofan Wang, Xinruo Wang, Zhonghua Shen, Jishi Wang, Jie Ma, Yujie Zhao, Zeying He
Fluoroquinolone antibiotics, widely used in daily life, contribute to environmental pollution due to their persistence in natural ecosystems. However, the degradation mechanism of fluoroquinolones remains elusive, which not only hinders the understanding of their environmental behavior but also restricts the development of effective remediations. This study investigates the degradation mechanism of enrofloxacin (ENR) through hydroxyl radicals (•OH), integrating density functional theory (DFT) calculations and experimental validations. The degradation process involves key steps such as bond activation (C–F, C–H, C–C) and decarboxylation, with the C–F bond and decarboxylation identified as rate-limiting steps. Experimental results confirm the theoretical predictions of degradation pathways and major by-products. Toxicity analysis shows that most degradation products exhibit significantly reduced toxicity compared to ENR. This work provides valuable insights into the degradation behavior of fluoroquinolones and lays the groundwork for designing advanced environmental remediation strategies.
{"title":"Unveiling the reaction pathways in the degradation mechanism of enrofloxacin by hydroxyl radicals: A DFT and experiment study","authors":"Wenjing Liu, Aofan Wang, Xinruo Wang, Zhonghua Shen, Jishi Wang, Jie Ma, Yujie Zhao, Zeying He","doi":"10.1016/j.jhazmat.2025.137950","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137950","url":null,"abstract":"Fluoroquinolone antibiotics, widely used in daily life, contribute to environmental pollution due to their persistence in natural ecosystems. However, the degradation mechanism of fluoroquinolones remains elusive, which not only hinders the understanding of their environmental behavior but also restricts the development of effective remediations. This study investigates the degradation mechanism of enrofloxacin (ENR) through hydroxyl radicals (•OH), integrating density functional theory (DFT) calculations and experimental validations. The degradation process involves key steps such as bond activation (C–F, C–H, C–C) and decarboxylation, with the C–F bond and decarboxylation identified as rate-limiting steps. Experimental results confirm the theoretical predictions of degradation pathways and major by-products. Toxicity analysis shows that most degradation products exhibit significantly reduced toxicity compared to ENR. This work provides valuable insights into the degradation behavior of fluoroquinolones and lays the groundwork for designing advanced environmental remediation strategies.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"20 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seagrasses growing in different eutrophic states in carbonate and terrigenous sediments may exhibit contrasting sulfide intrusion and responses; however, limited information is available. In this study, sulfide intrusion in the tropical typical seagrass Thalassia hemprichii along a eutrophication gradient in carbonate and terrigenous sediments on Hainan Island, South China Sea, was investigated using combined elements, stable isotopes, and photobiology. The sediment porewater sulfide concentration increased with rising nutrient levels, with porewater sulfide as 223.92±25.34 μmol/L when the dissolved inorganic nitrogen concentration was 10.83±0.60 μmol/L and the dissolved inorganic phosphate concentration was 0.39±0.01 μmol/L. The nutrient input significantly enhanced sulfide intrusion in seagrass, resulting in reduced δ34S values in roots from 12.78±1.16 to 2.69±0.46‰, with leaf δ15N as the greatest explanatory factor. In addition, sulfide intrusion inhibited photosynthesis more strongly in seagrass growing in carbonate sediments than in terrigenous sediments because of the low iron content in carbonate sediments (almost 50% of the iron content in terrigenous sediments), reducing rETRmax and Ek by 43.08% and 36.42%, respectively. Therefore, the synergistic effects of nutrient input, sulfide concentration, sediment substrate, and iron content affected the sulfide intrusion in seagrass.
{"title":"Sulfide intrusion of seagrass Thalassia hemprichii along a eutrophication gradient with carbonate and terrigenous sediments in tropical coastal sea","authors":"Wenqian Qi, Yijun Liu, Zhijian Jiang, Xu Long, Yang Fang, Uditha Thejan Egodauyana, Yunchao Wu, Songlin Liu, Xiaoping Huang","doi":"10.1016/j.jhazmat.2025.138005","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138005","url":null,"abstract":"Seagrasses growing in different eutrophic states in carbonate and terrigenous sediments may exhibit contrasting sulfide intrusion and responses; however, limited information is available. In this study, sulfide intrusion in the tropical typical seagrass <em>Thalassia hemprichii</em> along a eutrophication gradient in carbonate and terrigenous sediments on Hainan Island, South China Sea, was investigated using combined elements, stable isotopes, and photobiology. The sediment porewater sulfide concentration increased with rising nutrient levels, with porewater sulfide as 223.92±25.34 μmol/L when the dissolved inorganic nitrogen concentration was 10.83±0.60 μmol/L and the dissolved inorganic phosphate concentration was 0.39±0.01 μmol/L. The nutrient input significantly enhanced sulfide intrusion in seagrass, resulting in reduced δ<sup>34</sup>S values in roots from 12.78±1.16 to 2.69±0.46‰, with leaf δ<sup>15</sup>N as the greatest explanatory factor. In addition, sulfide intrusion inhibited photosynthesis more strongly in seagrass growing in carbonate sediments than in terrigenous sediments because of the low iron content in carbonate sediments (almost 50% of the iron content in terrigenous sediments), reducing rETR<sub>max</sub> and E<sub>k</sub> by 43.08% and 36.42%, respectively. Therefore, the synergistic effects of nutrient input, sulfide concentration, sediment substrate, and iron content affected the sulfide intrusion in seagrass.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"20 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-20DOI: 10.1016/j.jhazmat.2025.138006
Jin-jin Lv, Yu-jie Liu, Yan-hang Mo, Li-yan Deng, Yang Liu, Hong-ye Li, Li Zhang, Wei-dong Yang
Diarrheic shellfish toxins (DSTs) are a class of lipophilic algal toxins that accumulate excessively in bivalves following harmful algal blooms. Bivalves exhibit tolerance to DSTs, which make people ignore or underestimate the risk of DSTs, leading to the occurrence of seafood poisoning incidents. However, the tolerance mechanism remains unclear in bivalves. We investigated the role of extracellular-regulated protein kinase (ERK) in DSTs tolerance, observed that the ERK inhibitor PD98059 exacerbated damage of DSTs to the digestive tubules. PD98059 induced the TUNEL fluorescence intensity, and caspase-3 activity inhibited by DSTs were restored to the control. PD98059 enhanced the fluorescence intensity of extracellular Ca-AM and increased the accumulation of esterified DSTs. Transcriptome analysis revealed that PD98059 affected the genes expression related to apoptosis, ABC transporters, and lipid metabolism. qPCR analysis demonstrated that PD98059 down-regulated the DSTs-induced iap and ABCC10 (p = 0.063), and up-regulated ABCB1-like1, ABCC1, ABCC1-like1, and ABCC9. Molecular docking suggested that ABCC10 exhibited high affinity for esterified okadaic acid. Overall, ERK plays a crucial role in DSTs tolerance by regulating the anti-apoptotic system and ABC transporters in bivalves. Our study is of great significance to understand the tolerance mechanism in bivalves and the safety risk caused by DSTs.
{"title":"The tolerance mechanism of diarrhetic shellfish toxins mediated by the extracellular regulated protein kinase (ERK) pathway in the mussel Perna viridis","authors":"Jin-jin Lv, Yu-jie Liu, Yan-hang Mo, Li-yan Deng, Yang Liu, Hong-ye Li, Li Zhang, Wei-dong Yang","doi":"10.1016/j.jhazmat.2025.138006","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138006","url":null,"abstract":"Diarrheic shellfish toxins (DSTs) are a class of lipophilic algal toxins that accumulate excessively in bivalves following harmful algal blooms. Bivalves exhibit tolerance to DSTs, which make people ignore or underestimate the risk of DSTs, leading to the occurrence of seafood poisoning incidents. However, the tolerance mechanism remains unclear in bivalves. We investigated the role of extracellular-regulated protein kinase (ERK) in DSTs tolerance, observed that the ERK inhibitor PD98059 exacerbated damage of DSTs to the digestive tubules. PD98059 induced the TUNEL fluorescence intensity, and caspase-3 activity inhibited by DSTs were restored to the control. PD98059 enhanced the fluorescence intensity of extracellular Ca-AM and increased the accumulation of esterified DSTs. Transcriptome analysis revealed that PD98059 affected the genes expression related to apoptosis, ABC transporters, and lipid metabolism. qPCR analysis demonstrated that PD98059 down-regulated the DSTs-induced <em>iap</em> and <em>ABCC10</em> (<em>p</em> = 0.063), and up-regulated <em>ABCB1-like1</em>, <em>ABCC1</em>, <em>ABCC1-like1</em>, and <em>ABCC9</em>. Molecular docking suggested that ABCC10 exhibited high affinity for esterified okadaic acid. Overall, ERK plays a crucial role in DSTs tolerance by regulating the anti-apoptotic system and ABC transporters in bivalves. Our study is of great significance to understand the tolerance mechanism in bivalves and the safety risk caused by DSTs.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"88 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-19DOI: 10.1016/j.jhazmat.2025.137975
Shahid Ahmad Dar, Khalid Muzamil Gani
Microplastics (MPs) and nanoplastics (NPs) have been largely studied in marine environments, but there lies a significant gap in assessing their occurrence and impacts in glacier environments. This study investigates the occurrence and pollution risks of MPs and NPs in glaciers, suspended air, and dry deposition across the northwestern Himalayas. MPs concentration ranged from 1000 particles m-3 in Kolahai glacier to 151000 particles m-3 in Thajwas glacier. In suspended air, MPs occurred at 5 particles m-3, while dry deposition samples showed a concentration ranging from 1-13 particles m-2 d-1. Dynamic light scattering (DLS) confirmed the presence of NPs in all glaciers, with sizes varying between 31-689 nm in Thajwas glacier and 360-953 nm in Harmukh glacier. HYSPLIT modelling revealed that air masses reaching Himalayan glaciers predominantly originate from global sources (75%). The pollution load index (PLI) ranged from 3.9 (hazard category I) to 40 (hazard category IV), indicating moderate to excessive pollution of glaciers. While as polymer hazard index (PHI) ranged from 10 (hazard category II) to 1987 (hazard category V), indicating medium to extreme danger due to presence of polyvinyl chloride (PVC) and polyacrylonitrile (PAN). The presence of MPs and NPs accelerate glacier melting due to their light absorbing properties underscoring need for further studies.
{"title":"Deciphering the source contribution of microplastics in the glaciers of the North-Western Himalayas","authors":"Shahid Ahmad Dar, Khalid Muzamil Gani","doi":"10.1016/j.jhazmat.2025.137975","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137975","url":null,"abstract":"Microplastics (MPs) and nanoplastics (NPs) have been largely studied in marine environments, but there lies a significant gap in assessing their occurrence and impacts in glacier environments. This study investigates the occurrence and pollution risks of MPs and NPs in glaciers, suspended air, and dry deposition across the northwestern Himalayas. MPs concentration ranged from 1000 particles m<sup>-3</sup> in Kolahai glacier to 151000 particles m<sup>-3</sup> in Thajwas glacier. In suspended air, MPs occurred at 5 particles m<sup>-3</sup>, while dry deposition samples showed a concentration ranging from 1-13 particles m<sup>-2</sup> d<sup>-1</sup>. Dynamic light scattering (DLS) confirmed the presence of NPs in all glaciers, with sizes varying between 31-689<!-- --> <!-- -->nm in Thajwas glacier and 360-953<!-- --> <!-- -->nm in Harmukh glacier. HYSPLIT modelling revealed that air masses reaching Himalayan glaciers predominantly originate from global sources (75%). The pollution load index (PLI) ranged from 3.9 (hazard category I) to 40 (hazard category IV), indicating moderate to excessive pollution of glaciers. While as polymer hazard index (PHI) ranged from 10 (hazard category II) to 1987 (hazard category V), indicating medium to extreme danger due to presence of polyvinyl chloride (PVC) and polyacrylonitrile (PAN). The presence of MPs and NPs accelerate glacier melting due to their light absorbing properties underscoring need for further studies.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"18 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-19DOI: 10.1016/j.jhazmat.2025.137972
Julia Udvary, Regina Schwerd, Sabine Johann, Brigitte Helmreich
Stormwater runoff from urban surfaces contains pollutants that harm the water quality of surface or groundwater bodies. While runoff quality from metal roofs has already been widely studied, the contribution of non-metal roofing materials to stormwater pollution is still unclear. A leaching test was conducted to determine the substance emission from non-metal roofing materials. Analyzing parameters in the leachate of eight leaching rounds at predefined time intervals allowed for determining area release rates and leaching mechanisms. The test was conducted with commonly used materials applied on inclined roofs: clay tiles, concrete tiles, fiber cement, bitumen shingles, wood shingles, and plastic roofing tiles. The scope of the analysis is based on substances repeatedly detected in stormwater: anions, cations, heavy metals, biocides, phthalates, PCBs, PFAS, PAHs, nonylphenols, and Bisphenol A. Several roofing materials released relevant amounts of hazardous substances impacting water quality. Clay tiles are a source of vanadium, manganese, and arsenic. Treated wood shingles release ammonium, boron, copper, and Bisphenol A. Fiber cement and concrete roofing tiles are a source of biocides. Bitumen shingles released Bisphenol A. Further research is recommended regarding leaching in long-term field experiments to evaluate the impact of real weather conditions on and on developing treatment facilities.
{"title":"Non-metal Roofing Materials as Potential Sources for Pollutants- Laboratory Leaching Studies on Various Roofing Materials","authors":"Julia Udvary, Regina Schwerd, Sabine Johann, Brigitte Helmreich","doi":"10.1016/j.jhazmat.2025.137972","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137972","url":null,"abstract":"Stormwater runoff from urban surfaces contains pollutants that harm the water quality of surface or groundwater bodies. While runoff quality from metal roofs has already been widely studied, the contribution of non-metal roofing materials to stormwater pollution is still unclear. A leaching test was conducted to determine the substance emission from non-metal roofing materials. Analyzing parameters in the leachate of eight leaching rounds at predefined time intervals allowed for determining area release rates and leaching mechanisms. The test was conducted with commonly used materials applied on inclined roofs: clay tiles, concrete tiles, fiber cement, bitumen shingles, wood shingles, and plastic roofing tiles. The scope of the analysis is based on substances repeatedly detected in stormwater: anions, cations, heavy metals, biocides, phthalates, PCBs, PFAS, PAHs, nonylphenols, and Bisphenol A. Several roofing materials released relevant amounts of hazardous substances impacting water quality. Clay tiles are a source of vanadium, manganese, and arsenic. Treated wood shingles release ammonium, boron, copper, and Bisphenol A. Fiber cement and concrete roofing tiles are a source of biocides. Bitumen shingles released Bisphenol A. Further research is recommended regarding leaching in long-term field experiments to evaluate the impact of real weather conditions on and on developing treatment facilities.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"183 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-19DOI: 10.1016/j.jhazmat.2025.137970
Zhao Jie Chen, Xu Zhen Shi, Ya Nan Qu, Si Ying Li, Gan Ai, Yi Zhuo Wang, Li Qing Zeng, Xiao Liang Liu, Xuesheng Li, Yan Hui Wang
Glycine betaine (GB), a secondary metabolite that regulates plant responses to biotic and abiotic stresses, may help reduce pesticide phytotoxicity, but this fact remains unestablished. This study investigated the physiological response of rice (Oryza sativa) to six dosages of oxyfluorfen (OFF) (0–0.25 mg/L) and two concentrations of GB (0 and 175 mg/L). GB treatment counteracted the considerable decrease in rice seedling growth caused by OFF treatment at doses higher than 0.15 mg/L. The biochemical processes and catalytic events associated with OFF-triggered degradation in rice were investigated using RNA-Seq–LC–Q-TOF–HRMS/MS after six rice root and shoot libraries were created and subjected to either OFF or OFF–GB. Rice treated with both GB and an ecologically relevant dose of OFF showed a marked upregulation of 1039 root genes and 111 shoot genes compared with those treated with OFF alone. Multiple OFF-degradative enzymes implicated in molecular metabolism and xenobiotic tolerance to environmental stress were identified by gene enrichment analysis. In comparison to treated with 0.25 mg/L OFF alone, exogenous GB administration decreased OFF accumulation, with the OFF concentration in roots being 44.47% and in shoots being 51.03%. The production of essential enzymes involved in the OFF decay process was attributed to certain genes with variable expression, including cytochrome P450, methyltransferase, glycosyltransferases, and acetyltransferases. Using LC-Q-TOF-HRMS/MS, 3 metabolites and 16 conjugates were identified in metabolic pathways including hydrolysis, acetylation, glycosylation, and interaction with amino acids in order to enhance OFF-degradative metabolism. All things considered, by reducing phytotoxicity and OFF buildup, external GB treatment can increase rice's resistance to oxidative stress caused by OFF. This study offers valuable insights into the function of GB in enhancing OFF degradation, which may have ramifications for designing genotypes that maximize OFF accumulation in rice crops and promote OFF degradation in paddy crops.
{"title":"Insights into the synergistic effects of exogenous glycine betaine on the multiphase metabolism of oxyfluorfen in Oryza sativa for reducing environmental risks","authors":"Zhao Jie Chen, Xu Zhen Shi, Ya Nan Qu, Si Ying Li, Gan Ai, Yi Zhuo Wang, Li Qing Zeng, Xiao Liang Liu, Xuesheng Li, Yan Hui Wang","doi":"10.1016/j.jhazmat.2025.137970","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137970","url":null,"abstract":"Glycine betaine (GB), a secondary metabolite that regulates plant responses to biotic and abiotic stresses, may help reduce pesticide phytotoxicity, but this fact remains unestablished. This study investigated the physiological response of rice (<em>Oryza sativa</em>) to six dosages of oxyfluorfen (OFF) (0–0.25<!-- --> <!-- -->mg/L) and two concentrations of GB (0 and 175<!-- --> <!-- -->mg/L). GB treatment counteracted the considerable decrease in rice seedling growth caused by OFF treatment at doses higher than 0.15<!-- --> <!-- -->mg/L. The biochemical processes and catalytic events associated with OFF-triggered degradation in rice were investigated using RNA-Seq–LC–Q-TOF–HRMS/MS after six rice root and shoot libraries were created and subjected to either OFF or OFF–GB. Rice treated with both GB and an ecologically relevant dose of OFF showed a marked upregulation of 1039 root genes and 111 shoot genes compared with those treated with OFF alone. Multiple OFF-degradative enzymes implicated in molecular metabolism and xenobiotic tolerance to environmental stress were identified by gene enrichment analysis. In comparison to treated with 0.25<!-- --> <!-- -->mg/L OFF alone, exogenous GB administration decreased OFF accumulation, with the OFF concentration in roots being 44.47% and in shoots being 51.03%. The production of essential enzymes involved in the OFF decay process was attributed to certain genes with variable expression, including cytochrome P450, methyltransferase, glycosyltransferases, and acetyltransferases. Using LC-Q-TOF-HRMS/MS, 3 metabolites and 16 conjugates were identified in metabolic pathways including hydrolysis, acetylation, glycosylation, and interaction with amino acids in order to enhance OFF-degradative metabolism. All things considered, by reducing phytotoxicity and OFF buildup, external GB treatment can increase rice's resistance to oxidative stress caused by OFF. This study offers valuable insights into the function of GB in enhancing OFF degradation, which may have ramifications for designing genotypes that maximize OFF accumulation in rice crops and promote OFF degradation in paddy crops.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"6 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-19DOI: 10.1016/j.jhazmat.2025.137980
Huan Xu, Kun Huang, Biao Zhang, Huihua Yang, Jie Wang, Xinyue Li, Xia Meng, Renjie Chen, Xiaomin Zhang
Epidemiological evidence linking air pollution to children’s thyroid function is inconsistent, and the role of metabolites remains unknown. We conducted a panel study with 3 repeated visits among 143 children aged 4-12 years. The outdoor levels of ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, and fine particulate matter were estimated 3 consecutive days preceding blood draw. Exposure to ozone was linearly associated with the reduction of free thyroxine (FT4) only at lag 0 day. Bayesian kernel machine regression and weighted quantile sum regression indicated that exposure to air pollution mixture linked to reduced FT4 at lag 0 day, with ozone being the primary contributor. Untargeted metabolomics were measured in 48 children, revealing that 27 serum metabolites were associated with ozone, primarily involving ether lipid and glycerophospholipid metabolism pathways. Casual inference tests showed that eight glycerophospholipid metabolites were identified as mediators of ozone's effect on FT4, seven of which were involved in ether lipid pathway. The integrated analysis identified a cluster of children with reduced FT4, characterized by increased ozone and decreased phosphatidylethanolamine plasmalogen and alkyl-phosphatidylcholine. Our findings suggested that short-term exposure to outdoor ozone in children may disrupt glycerophospholipid levels within the ether lipid metabolic pathway, leading to reduced FT4.
{"title":"Associations of Outdoor Ozone Concentration with Thyroid Function and the Mediated Role of Serum Metabolites: A Panel Study of Healthy Children","authors":"Huan Xu, Kun Huang, Biao Zhang, Huihua Yang, Jie Wang, Xinyue Li, Xia Meng, Renjie Chen, Xiaomin Zhang","doi":"10.1016/j.jhazmat.2025.137980","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137980","url":null,"abstract":"Epidemiological evidence linking air pollution to children’s thyroid function is inconsistent, and the role of metabolites remains unknown. We conducted a panel study with 3 repeated visits among 143 children aged 4-12 years. The outdoor levels of ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, and fine particulate matter were estimated 3 consecutive days preceding blood draw. Exposure to ozone was linearly associated with the reduction of free thyroxine (FT4) only at lag 0 day. Bayesian kernel machine regression and weighted quantile sum regression indicated that exposure to air pollution mixture linked to reduced FT4 at lag 0 day, with ozone being the primary contributor. Untargeted metabolomics were measured in 48 children, revealing that 27 serum metabolites were associated with ozone, primarily involving ether lipid and glycerophospholipid metabolism pathways. Casual inference tests showed that eight glycerophospholipid metabolites were identified as mediators of ozone's effect on FT4, seven of which were involved in ether lipid pathway. The integrated analysis identified a cluster of children with reduced FT4, characterized by increased ozone and decreased phosphatidylethanolamine plasmalogen and alkyl-phosphatidylcholine. Our findings suggested that short-term exposure to outdoor ozone in children may disrupt glycerophospholipid levels within the ether lipid metabolic pathway, leading to reduced FT4.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"20 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-19DOI: 10.1016/j.jhazmat.2025.137995
Jihee Kim, Ana Gabriela Chuquer Licto, Kyungjin Cho, Eun-Ju Kim
Microplastics (MPs) entering wastewater treatment plants accumulate in sludge and are subsequently introduced into anaerobic digesters, a key sludge treatment process. However, little is known about how MPs undergo transformation during anaerobic digestion (AD). This study investigated the mechanism underlying the aging of polystyrene (PS) MPs in AD and its effect on heavy metal adsorption. In the AD batches containing an initial sulfate concentration of 5.1 mM, significant sulfate reduction (96.1%) was observed, with reduced sulfur species accounting for 74% of the total sulfur species deposited on the PS surface, as revealed by X-ray photoelectron spectroscopy. A positive correlation between sulfide formation and the selective proliferation of sulfur-reducing bacteria, particularly Desulfovibrio aminophilus, indicated the involvement of microorganisms in sulfur aging. The decomposition of in situ hydrogen peroxide (H2O2) and formation of hydroxyl radicals (∙OH) under sulfidogenic conditions were more pronounced, suggesting that reactive oxygen species may induce structural changes in PS MPs and potentially facilitate sulfur aging. Finally, isothermal titration calorimetry results showed that sulfur-aged PS had higher binding constants for Pb²⁺ and Cu²⁺ compared to pristine PS, due to the presence of sulfur-containing functional groups and a more negative surface charge. These findings provide valuable insights into the fate of MPs during the sludge treatment and their potential environmental impacts.
{"title":"In situ formed sulfide–mediated aging of polystyrene microplastics and its impact on the fate of heavy metals in anaerobic digestion","authors":"Jihee Kim, Ana Gabriela Chuquer Licto, Kyungjin Cho, Eun-Ju Kim","doi":"10.1016/j.jhazmat.2025.137995","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137995","url":null,"abstract":"Microplastics (MPs) entering wastewater treatment plants accumulate in sludge and are subsequently introduced into anaerobic digesters, a key sludge treatment process. However, little is known about how MPs undergo transformation during anaerobic digestion (AD). This study investigated the mechanism underlying the aging of polystyrene (PS) MPs in AD and its effect on heavy metal adsorption. In the AD batches containing an initial sulfate concentration of 5.1<!-- --> <!-- -->mM, significant sulfate reduction (96.1%) was observed, with reduced sulfur species accounting for 74% of the total sulfur species deposited on the PS surface, as revealed by X-ray photoelectron spectroscopy. A positive correlation between sulfide formation and the selective proliferation of sulfur-reducing bacteria, particularly <em>Desulfovibrio aminophilus</em>, indicated the involvement of microorganisms in sulfur aging. The decomposition of <em>in situ</em> hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and formation of hydroxyl radicals (∙OH) under sulfidogenic conditions were more pronounced, suggesting that reactive oxygen species may induce structural changes in PS MPs and potentially facilitate sulfur aging. Finally, isothermal titration calorimetry results showed that sulfur-aged PS had higher binding constants for Pb²⁺ and Cu²⁺ compared to pristine PS, due to the presence of sulfur-containing functional groups and a more negative surface charge. These findings provide valuable insights into the fate of MPs during the sludge treatment and their potential environmental impacts.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"126 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-19DOI: 10.1016/j.jhazmat.2025.137978
Georges Hatem, Ana Margarida Faria, Mariana Bessa Pinto, Amina Salamova, João Paulo Teixeira, Carla Costa, Joana Madureira
Despite being previously banned due to long-term health effects, Per- and polyfluoroalkyl substances (PFAS) remain widespread in the environment, accumulating in animals and humans. This systematic review and meta-analysis explores associations between exposure to PFAS and asthma onset, wheezing, atopic dermatitis, and eczema in children and adolescents while addressing exposure timing and sex-specific differences. After comprehensive search conducted in several databases, including risk of bias, study heterogeneity, and quality of evidence evaluation, the review included 28 observational studies, most with low risk of bias in all domains. PFAS exposure was not significantly associated with asthma onset (OR:1.03, CI:0.99;1.07), but revealed significantly lower association in the prenatal period (OR:0.97, CI:0.94;0.99), higher in the postnatal period (OR:1.20, CI:1.07;1.35), and no differences among sexes. PFAS exposure (mainly prenatal) was associated with 4% significantly lower odds of wheezing (OR:0.96, CI:0.94;0.98), higher in girls (OR:0.94, CI:0.91;0.98) than in boys (OR:0.97, CI:0.94;1.00). No significant impact was noted on atopic dermatitis (OR:1.04, CI:0.94;1.16), while PFAS exposure was associated with 8% significantly lower eczema odds (OR:0.92, CI:0.89;0.96). Evidence was insufficient to perform sensitivity analyses on atopic dermatitis and eczema. Additional research is needed on the impact of synergistic and co-exposure to other pollutants on children and adolescents' health.
{"title":"Exposure to per-and poly-fluoroalkyl substances and respiratory and skin effects in children and adolescents: A systematic review and meta-analysis","authors":"Georges Hatem, Ana Margarida Faria, Mariana Bessa Pinto, Amina Salamova, João Paulo Teixeira, Carla Costa, Joana Madureira","doi":"10.1016/j.jhazmat.2025.137978","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137978","url":null,"abstract":"Despite being previously banned due to long-term health effects, Per- and polyfluoroalkyl substances (PFAS) remain widespread in the environment, accumulating in animals and humans. This systematic review and meta-analysis explores associations between exposure to PFAS and asthma onset, wheezing, atopic dermatitis, and eczema in children and adolescents while addressing exposure timing and sex-specific differences. After comprehensive search conducted in several databases, including risk of bias, study heterogeneity, and quality of evidence evaluation, the review included 28 observational studies, most with low risk of bias in all domains. PFAS exposure was not significantly associated with asthma onset (OR:1.03, CI:0.99;1.07), but revealed significantly lower association in the prenatal period (OR:0.97, CI:0.94;0.99), higher in the postnatal period (OR:1.20, CI:1.07;1.35), and no differences among sexes. PFAS exposure (mainly prenatal) was associated with 4% significantly lower odds of wheezing (OR:0.96, CI:0.94;0.98), higher in girls (OR:0.94, CI:0.91;0.98) than in boys (OR:0.97, CI:0.94;1.00). No significant impact was noted on atopic dermatitis (OR:1.04, CI:0.94;1.16), while PFAS exposure was associated with 8% significantly lower eczema odds (OR:0.92, CI:0.89;0.96). Evidence was insufficient to perform sensitivity analyses on atopic dermatitis and eczema. Additional research is needed on the impact of synergistic and co-exposure to other pollutants on children and adolescents' health.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"29 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Small plastic fragments (<5 mm, i.e., microplastics, MPs) accumulate in ecosystems, resulting in increasing concerns about their toxic effects in the terrestrial environment. While studies on MPs in the soil environment are expanding, gaps in knowledge still exist regarding their effects on soil (macro)organisms. Our study aimed to measure the response of Cantareus aspersus snails to long-term exposure to 0.1, 1 and 10% w/w polyethylene (PE), polyamide (PA) or polystyrene (PS) particles in food. Overall, a concentration-dependent decrease in snail growth was observed, as was a general trend toward earlier maturity at low and middle MP concentrations. Mild (for PS) to severe (for PE and PA) effects on reproduction were detected but without a concentration-dependent trend. The fecundity was affected mainly by PE at 1% (-32.9%) and by PA at 1% (-52.59%), and their fertility was reduced by 43.9% and 61.3%, respectively. This decrease was related to increased survival, suggesting trade-offs in snail energy allocation and/or endocrine regulation. This study revealed that an environmentally relevant life-cycle assessment of toxic effects allows the detection of subtle effects regarding individual responses. These effects allowed us to demonstrate differential impacts on animal health status according to the polymer used and the exposure concentration.
{"title":"Ecotoxicological impacts of polyethylene, polystyrene and polyamide on the land snail Cantareus aspersus in a life cycle experiment","authors":"Romain Colpaert, Annette de Vaufleury, Clémentine Fritsch, Dominique Rieffel, Frédéric Gimbert","doi":"10.1016/j.jhazmat.2025.137968","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137968","url":null,"abstract":"Small plastic fragments (<5<!-- --> <!-- -->mm, <em>i.e.</em>, microplastics, MPs) accumulate in ecosystems, resulting in increasing concerns about their toxic effects in the terrestrial environment. While studies on MPs in the soil environment are expanding, gaps in knowledge still exist regarding their effects on soil (macro)organisms. Our study aimed to measure the response of <em>Cantareus aspersus</em> snails to long-term exposure to 0.1, 1 and 10% w/w polyethylene (PE), polyamide (PA) or polystyrene (PS) particles in food. Overall, a concentration-dependent decrease in snail growth was observed, as was a general trend toward earlier maturity at low and middle MP concentrations. Mild (for PS) to severe (for PE and PA) effects on reproduction were detected but without a concentration-dependent trend. The fecundity was affected mainly by PE at 1% (-32.9%) and by PA at 1% (-52.59%), and their fertility was reduced by 43.9% and 61.3%, respectively. This decrease was related to increased survival, suggesting trade-offs in snail energy allocation and/or endocrine regulation. This study revealed that an environmentally relevant life-cycle assessment of toxic effects allows the detection of subtle effects regarding individual responses. These effects allowed us to demonstrate differential impacts on animal health status according to the polymer used and the exposure concentration.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"91 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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