Gut Microbiota Dysbiosis: A Neglected Risk Factor for Male and Female Fertility

IF 2.6 2区 生物学 Q3 CELL BIOLOGY Cellular Microbiology Pub Date : 2024-11-20 DOI:10.1155/cmi/7808354
Faeze Ahmadi Beni, Hossein Saffarfar, Anis Elhami, Mohammad Kazemi
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Abstract

Infertility is a condition where a male or female is unable to achieve pregnancy through at least 1 year of regular, unprotected sexual intercourse. There are several known causes and risk factors associated with infertility. The gut microbiota is a complex community of trillions of microorganisms living in the gut. Due to modern lifestyle changes, such as dietary habits, physical inactivity, and increasing antibiotic use, the diversity and composition of these microbes may change in a detrimental manner. Dysbiosis or an imbalance of the gut microbiota compared to a normal composition can lead to various abnormalities, such as obesity, Alzheimer’s, metabolic disorders, and infertility. This review will cover the factors influencing gut microbiota composition, the mechanisms by which gut microbiota contributes to infertility in men and women, the effects of gut microbiota on problems that may arise during pregnancy, and therapeutic methods for diseases caused by dysbiosis of the gut microbiota.

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肠道微生物群失调:被忽视的男女生育风险因素
不孕症是指男性或女性通过至少 1 年的定期、无保护性交而无法怀孕的情况。与不孕症相关的原因和风险因素有多种。肠道微生物群是由生活在肠道中的数万亿微生物组成的复杂群落。由于现代生活方式的改变,如饮食习惯、缺乏运动和越来越多地使用抗生素,这些微生物的多样性和组成可能会发生不利的变化。菌群失调或肠道微生物群与正常组成相比失衡会导致各种异常现象,如肥胖、老年痴呆、代谢紊乱和不孕不育。本综述将介绍影响肠道微生物群组成的因素、肠道微生物群导致男性和女性不孕症的机制、肠道微生物群对怀孕期间可能出现的问题的影响,以及治疗肠道微生物群失调引起的疾病的方法。
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来源期刊
Cellular Microbiology
Cellular Microbiology 生物-微生物学
CiteScore
9.70
自引率
0.00%
发文量
26
审稿时长
3 months
期刊介绍: Cellular Microbiology aims to publish outstanding contributions to the understanding of interactions between microbes, prokaryotes and eukaryotes, and their host in the context of pathogenic or mutualistic relationships, including co-infections and microbiota. We welcome studies on single cells, animals and plants, and encourage the use of model hosts and organoid cultures. Submission on cell and molecular biological aspects of microbes, such as their intracellular organization or the establishment and maintenance of their architecture in relation to virulence and pathogenicity are also encouraged. Contributions must provide mechanistic insights supported by quantitative data obtained through imaging, cellular, biochemical, structural or genetic approaches.
期刊最新文献
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