Wear, Material Transfer, and Electrocautery Damage Are Ubiquitous on CoCrMo Femoral Knee Retrievals

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2024-11-20 DOI:10.1002/jbm.b.35504
Peter W. Kurtz, Michael A. Kurtz, Shabnam Aslani, Lilliana M. Taylor, Charley M. Goodwin, Daniel W. MacDonald, Nicolas S. Piuzzi, William M. Mihalko, Steven M. Kurtz, Jeremy L. Gilbert
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Abstract

Despite high total knee arthroplasty (TKA) survivorship after 10 years (92%–99%), a gap persists where patient satisfaction lags clinical success. Additionally, while cobalt chrome molybdenum (CoCrMo) use decreases in primary total hip arthroplasty, the alloy continues to be widely used in TKA femoral components. In vivo, CoCrMo degradation may be associated with adverse local tissue reactions (ALTR) and compared with the hip, the damage mechanisms that may release metal in the knee and the potential biological effects remain poorly understood. In this study, we characterized the damage on 50 retrieved CoCrMo femoral knee implants paired with 19 titanium alloy and 31 CoCrMo tibial baseplates. We asked (1) what damage modes can release CoCrMo debris in vivo from femoral components and (2) how frequently does the damage occur? First, we developed a semiquantitative scoring system for abrasive wear. Then, we characterized damage modes on CoCrMo femoral implants using digital optical microscopy (DOM), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS). We found that wear, electrocautery damage, and Ti-6Al-4V material transfer were ubiquitous. Of the 50 CoCrMo femoral implants we investigated, we documented wear on 100% (n = 50/50), electrocautery damage on 98% (n = 49/50), and Ti-6Al-4V material transfer to the posterior condyles on 95% (n = 18/19). Our results suggest that these damage modes may be more prevalent than previously thought and may act as metal release mechanisms in vivo.

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磨损、材料转移和电灼损伤在钴铬钼股骨膝关节取出术中普遍存在
尽管全膝关节置换术(TKA)10 年后的存活率很高(92%-99%),但患者满意度落后于临床成功率的差距依然存在。此外,虽然钴铬钼(CoCrMo)在初级全髋关节置换术中的使用有所减少,但该合金仍在全膝关节置换术(TKA)股骨组件中广泛使用。在体内,CoCrMo 的降解可能与局部组织不良反应(ALTR)有关,与髋关节相比,膝关节中可能释放金属的损伤机制及其潜在的生物效应仍鲜为人知。在这项研究中,我们对 50 个取回的 CoCrMo 股骨膝关节植入物以及 19 个钛合金和 31 个 CoCrMo 胫骨基板的损伤进行了鉴定。我们的问题是:(1) 什么样的损伤模式会在体内从股骨组件中释放出 CoCrMo 碎片;(2) 损伤发生的频率如何?首先,我们开发了一种半定量的磨损评分系统。然后,我们使用数字光学显微镜(DOM)、扫描电子显微镜(SEM)和能量色散 X 射线光谱(EDS)对 CoCrMo 股骨植入物的损伤模式进行了表征。我们发现,磨损、电灼损伤和 Ti-6Al-4V 材料转移无处不在。在我们研究的 50 个 CoCrMo 股骨植入物中,我们记录了 100% 的磨损(n = 50/50)、98% 的电烧损坏(n = 49/50)和 95% 的 Ti-6Al-4V 材料转移到后髁(n = 18/19)。我们的结果表明,这些损伤模式可能比以前认为的更为普遍,并可能成为体内金属释放机制。
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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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