Risk Assessment of Ochratoxin A (OTA) exposure from coffee consumption in Indonesia using Margin of Exposure (MOE) approach.

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY Food and Chemical Toxicology Pub Date : 2024-11-17 DOI:10.1016/j.fct.2024.115119

Ananditya Nugraha, Kenneth Francis Wibisono, Eleonora Valentia Sode Muda, Patricia Cahya, Michella Eleanor

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Abstract

Ochratoxin A (OTA) is a mycotoxin widely found in foodstuffs that is suspected to pose adverse health effects on humans. As one of the biggest coffee-producing countries, Indonesia face challenges in managing the OTA contamination at reasonable levels in coffee. A favorable climate for fungi growth and inappropriate food safety practices are several issues faced in Indonesia for managing the OTA contamination in coffee products. Nevertheless, studies about risk analysis exposure of OTA from coffee consumption in Indonesia is limited. Hence, the present study aimed to evaluate the risk of exposure to OTA from coffee consumption using the Margin of Exposure Approach (MOE) based on coffee provincial consumption data. Risk assessment using the MOE approach revealed that the OTA exposure from coffee consumption in Indonesia is generally of concern. The MOE values derived in the present study were generally below 1,000. Several Indonesian provinces even have MOE values below 200, indicating a greater concern of exposure. Overall, the present study highlights the importance of food safety management in Indonesian coffee production to minimize the OTA exposure from coffee consumption.

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采用暴露限值（MOE）法评估印度尼西亚人从饮用咖啡中摄入赭曲霉毒素 A（OTA）的风险。

赭曲霉毒素 A（OTA）是一种广泛存在于食品中的霉菌毒素，被怀疑会对人体健康造成不良影响。作为最大的咖啡生产国之一，印度尼西亚在将咖啡中的 OTA 污染控制在合理水平方面面临挑战。有利于真菌生长的气候和不恰当的食品安全做法是印尼在管理咖啡产品中 OTA 污染时面临的几个问题。然而，有关印度尼西亚咖啡消费中 OTA 暴露风险分析的研究十分有限。因此，本研究旨在根据各省的咖啡消费数据，采用暴露边际法（MOE）评估咖啡消费中暴露于 OTA 的风险。使用暴露限值法进行的风险评估显示，印度尼西亚人从咖啡消费中摄入的 OTA 总体上值得关注。本研究得出的暴露限值普遍低于 1,000。印度尼西亚有几个省的暴露限值甚至低于 200，这表明人们对咖啡暴露的关注度更高。总之，本研究强调了印度尼西亚咖啡生产中食品安全管理的重要性，以尽量减少咖啡消费中的 OTA 暴露量。

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.