Protection of lutein against the neurotoxicity of cisplatin in the rat brain

Abstract

One of the biggest problems of cancer treatment is the harmful effects of these drugs on the healthy tissues and organs of the organism. Our study aims to determine the possible protective effects of Lutein (L) against the toxicity of the pharmacological substance Cisplatin (CS), which is used in the treatment of cancer, in the brain of rats, through biochemical and histopathological tests. In our study, lutein (L) (100 mg/kg, orally) was administered for brain toxicity caused by CS (10 mg/kg, intraperitoneal (i.p.)). The study was completed in 7 days with a total of 28 rats from 4 groups, each consisting of 7 subjects. Control, L, CS and CS + L. A decrease in MDA level and an increase in CAT, GSH and SOD levels were observed in the CS + L group compared to the CS group. In histopathological examinations, no significant pathological changes were detected in the cerebrum, while degeneration in Purkinje cells and apoptosis in neurons in the molecular and granular layers in the cerebellum were detected. It is understood from the study that L alleviates the results of oxidative stress, increases antioxidant functions and positively supports brain functions. It also demonstrates the ability of L to prevent CS-induced brain damage. Ultimately, L appears to be a applicable pharmacological agent in this damage.