Prognostic Significance of the Controlling Nutritional Status (CONUT) Score in Patients with Muscle-Invasive Bladder Cancer after Radical Cystectomy.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY Urology Journal Pub Date : 2024-11-16 DOI:10.22037/uj.v21i.8266

Cem Yücel, Enes Dumanli, Mahmut Can Karabacak, Esat Kaan Akbay, Mehmet Yoldas, Uygar Micoogullari, Yusuf Ozlem Ilbey, Mehmet Zeynel Keskin

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Abstract

Purpose: To assess the impact of the The Controlling Nutritional Status (CONUT) score, an indicator of nutritional status, on the survival and prognosis after radical cystectomy.

Materials and methods: The medical records of patients who underwent consecutive radical cystectomy operations with the diagnosis of muscle-invasive bladder cancer at our clinic were retrospectively examined. The patients were separated into two groups based on the cut-off CONUT score which was derived using the receiver operating characteristic (ROC) curve. The group with a CONUT score ≥ 3 was categorized as high CONUT, whereas the group with a CONUT score < 3 was categorized as low CONUT. The groups were compaired according to oncological outcomes and survival risk factors.

Results: Cancer-specific survival (CSS) and overall survival (OS) were statistically significantly lower in the High CONUT group compared to the Low CONUT group (p<0.001, p=0.024, respectively). Age (HR: 1.02, 95% CI: 1.006-1.04, p=0.011) and CONUT score (HR: 3.92, 95% CI: 2.66-5.77, p<0.001) were revealed to be independent prognostic variables in the multivariate analysis for OS.

Conclusion: The CONUT score was found to be an independent predictor of survival in patients with muscle-invasive bladder cancer in this study.

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根治性膀胱切除术后肌浸润性膀胱癌患者营养状况控制（CONUT）评分的预后意义

目的：评估营养状况指标--营养状况控制评分（CONUT）对根治性膀胱切除术后生存率和预后的影响：回顾性研究在本诊所接受根治性膀胱切除术并确诊为肌层浸润性膀胱癌患者的病历。根据接受者操作特征曲线（ROC）得出的临界 CONUT 评分，将患者分为两组。CONUT评分≥3分的一组被归类为高CONUT，而CONUT评分≥3分的一组则被归类为低CONUT：与低CONUT组相比，高CONUT组的癌症特异性生存率（CSS）和总生存率（OS）在统计学上明显较低（p结论：本研究发现，CONUT 评分是肌肉浸润性膀胱癌患者生存率的独立预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urology Journal UROLOGY & NEPHROLOGY-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.