{"title":"The role of MELK in cancer and its interactions with non-coding RNAs: Implications for therapeutic strategies","authors":"Dong Oh Moon","doi":"10.1016/j.bulcan.2024.10.009","DOIUrl":null,"url":null,"abstract":"<div><div>In the evolving landscape of cancer research, the identification of key molecular players that contribute to the disease's progression and resistance against treatments has become paramount. Among these, Maternal Embryonic Leucine Zipper Kinase (MELK) has emerged as a critical regulator of cancer cell proliferation, survival, and therapy evasion. Concurrently, the significance of non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in modulating gene expression and cancer phenotypes has been increasingly recognized. Given the pivotal roles both MELK and ncRNAs play within cancer biology, investigating their interactions presents a compelling new frontier for therapeutic innovation. This exploration not only promises to enhance our understanding of cancer's molecular underpinnings but also opens up avenues for developing novel targeted interventions. The rationale behind focusing on MELK-ncRNA crosstalk lies in the potential to disrupt these critical molecular interactions, thereby offering a novel strategy to counteract cancer progression and improve treatment outcomes.</div></div>","PeriodicalId":9365,"journal":{"name":"Bulletin Du Cancer","volume":"112 1","pages":"Pages 35-53"},"PeriodicalIF":1.1000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin Du Cancer","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0007455124003965","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In the evolving landscape of cancer research, the identification of key molecular players that contribute to the disease's progression and resistance against treatments has become paramount. Among these, Maternal Embryonic Leucine Zipper Kinase (MELK) has emerged as a critical regulator of cancer cell proliferation, survival, and therapy evasion. Concurrently, the significance of non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in modulating gene expression and cancer phenotypes has been increasingly recognized. Given the pivotal roles both MELK and ncRNAs play within cancer biology, investigating their interactions presents a compelling new frontier for therapeutic innovation. This exploration not only promises to enhance our understanding of cancer's molecular underpinnings but also opens up avenues for developing novel targeted interventions. The rationale behind focusing on MELK-ncRNA crosstalk lies in the potential to disrupt these critical molecular interactions, thereby offering a novel strategy to counteract cancer progression and improve treatment outcomes.
期刊介绍：
Without doubt, the ''Bulletin du Cancer'' is the French language publication of reference in the field of cancerology. Official organ of the French Society of Cancer, this journal covers all the information available, whether in the form of original articles or review articles, but also clinical cases and letters to the editor, including various disciplines as onco-hematology, solids tumors, medical oncology, pharmacology, epidemiology, biology as well as fundamental research in cancerology. The journal proposes a clinical and therapeutic approach of high scientific standard and regular updates in knowledge are thus made possible. Articles can be submitted in French or English.
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