Acupuncture improves the symptoms, serum ghrelin, and autonomic nervous system of patients with postprandial distress syndrome: a randomized controlled trial.

IF 5.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Chinese Medicine Pub Date : 2024-11-20 DOI:10.1186/s13020-024-01028-3

Zi-Tong Fu, Cun-Zhi Liu, Mi-Rim Kim, Yi-Duo Liu, Yu Wang, Yi-Ming Fu, Jing-Wen Yang, Na-Na Yang

{"title":"Acupuncture improves the symptoms, serum ghrelin, and autonomic nervous system of patients with postprandial distress syndrome: a randomized controlled trial.","authors":"Zi-Tong Fu, Cun-Zhi Liu, Mi-Rim Kim, Yi-Duo Liu, Yu Wang, Yi-Ming Fu, Jing-Wen Yang, Na-Na Yang","doi":"10.1186/s13020-024-01028-3","DOIUrl":null,"url":null,"abstract":"Background: Whether gastrointestinal hormones in patients with postprandial distress syndrome (PDS) are altered by acupuncture, and whether such alterations are related to the autonomic nervous system (ANS), remains an open question.Objective: This study aims to investigate the effects of acupuncture on symptoms, serum hormones, and ANS in PDS patients.Methods: This randomized controlled clinical trial was conducted at Beijing Hospital of Traditional Chinese Medicine affiliated with Capital Medical University. Sixty-two PDS patients were randomly assigned equally to acupuncture or sham acupuncture arm (3 sessions per week for 4-week). The main outcome measures which were evaluated at baseline and 4-week included cardinal symptoms, serum hormones including ghrelin, vasoactive intestinal peptide (VIP), substance P (SP), and ANS.Results: Among the 62 randomly assigned participants, 51 (82%) were included in the baseline characteristics and outcome analysis. Gastrointestinal symptoms including response rate (p = 0.001) and dyspepsia symptom severity (p = 0.002) were significantly improved after acupuncture treatment. Serum ghrelin concentration was significantly higher in acupuncture group than in sham acupuncture group (8.34 ± 3.00 ng/ml versus 6.52 ± 2.00 ng/ml, p = 0.022) after 4-week treatment, instead of VIP and SP (p > 0.05). The acupuncture group had significantly higher vagal activity, showing with increasing of high-frequency component (HF, p ≤ 0.001) and decreasing of the ratio of low-frequency and HF (p ≤ 0.001). In relationship analysis, the HF component exhibited a significant inverse correlation with symptom severity (R = - 0.501, p ≤ 0.001), but not with ghrelin level (R = 0.026, p = 0.865).Conclusion: Acupuncture may improve the symptoms and increase the ghrelin level of PDS patients, the therapeutic effect of acupuncture was associated with the alteration of vagal activity.Trial registration: The trial is registered with the ISRCTN registry, ISRCTN12511434. Registered 31 March 2017, https://www.isrctn.com/ .","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"19 1","pages":"162"},"PeriodicalIF":5.3000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580632/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13020-024-01028-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Whether gastrointestinal hormones in patients with postprandial distress syndrome (PDS) are altered by acupuncture, and whether such alterations are related to the autonomic nervous system (ANS), remains an open question.

Objective: This study aims to investigate the effects of acupuncture on symptoms, serum hormones, and ANS in PDS patients.

Methods: This randomized controlled clinical trial was conducted at Beijing Hospital of Traditional Chinese Medicine affiliated with Capital Medical University. Sixty-two PDS patients were randomly assigned equally to acupuncture or sham acupuncture arm (3 sessions per week for 4-week). The main outcome measures which were evaluated at baseline and 4-week included cardinal symptoms, serum hormones including ghrelin, vasoactive intestinal peptide (VIP), substance P (SP), and ANS.

Results: Among the 62 randomly assigned participants, 51 (82%) were included in the baseline characteristics and outcome analysis. Gastrointestinal symptoms including response rate (p = 0.001) and dyspepsia symptom severity (p = 0.002) were significantly improved after acupuncture treatment. Serum ghrelin concentration was significantly higher in acupuncture group than in sham acupuncture group (8.34 ± 3.00 ng/ml versus 6.52 ± 2.00 ng/ml, p = 0.022) after 4-week treatment, instead of VIP and SP (p > 0.05). The acupuncture group had significantly higher vagal activity, showing with increasing of high-frequency component (HF, p ≤ 0.001) and decreasing of the ratio of low-frequency and HF (p ≤ 0.001). In relationship analysis, the HF component exhibited a significant inverse correlation with symptom severity (R = - 0.501, p ≤ 0.001), but not with ghrelin level (R = 0.026, p = 0.865).

Conclusion: Acupuncture may improve the symptoms and increase the ghrelin level of PDS patients, the therapeutic effect of acupuncture was associated with the alteration of vagal activity.

Trial registration: The trial is registered with the ISRCTN registry, ISRCTN12511434. Registered 31 March 2017, https://www.isrctn.com/ .

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

针灸改善餐后不适综合征患者的症状、血清胃泌素和自主神经系统：随机对照试验。

背景：针灸是否会改变餐后不适综合征（PDS）患者的胃肠激素，以及这种改变是否与自主神经系统（ANS）有关，仍是一个未决问题：本研究旨在探讨针灸对 PDS 患者的症状、血清激素和自律神经系统的影响：这项随机对照临床试验在首都医科大学附属北京中医医院进行。62名PDS患者被随机平均分配到针灸组和假针灸组（每周3次，共4周）。主要结果指标包括主要症状、血清激素（包括胃泌素、血管活性肠肽（VIP）、P 物质（SP）和 ANS）：在 62 名随机分配的参与者中，51 人（82%）被纳入基线特征和结果分析。针灸治疗后，胃肠道症状包括反应率（p = 0.001）和消化不良症状严重程度（p = 0.002）均有明显改善。治疗4周后，针刺组血清胃泌素浓度明显高于假针刺组（8.34 ± 3.00 ng/ml 对 6.52 ± 2.00 ng/ml, p = 0.022），而非VIP和SP（p > 0.05）。针刺组迷走神经活动明显增加，表现为高频成分（HF，p ≤ 0.001）增加和低频与 HF 比值下降（p ≤ 0.001）。在关系分析中，高频成分与症状严重程度呈显著的反相关（R = - 0.501，p ≤ 0.001），但与胃泌素水平不相关（R = 0.026，p = 0.865）：结论：针灸可改善PDS患者的症状并提高胃泌素水平，针灸的治疗效果与迷走神经活动的改变有关：该试验已在ISRCTN注册，ISRCTN12511434。注册日期为2017年3月31日，https://www.isrctn.com/ 。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.90

自引率

4.10%

发文量

133

审稿时长

31 weeks

期刊介绍： Chinese Medicine is an open access, online journal publishing evidence-based, scientifically justified, and ethical research into all aspects of Chinese medicine. Areas of interest include recent advances in herbal medicine, clinical nutrition, clinical diagnosis, acupuncture, pharmaceutics, biomedical sciences, epidemiology, education, informatics, sociology, and psychology that are relevant and significant to Chinese medicine. Examples of research approaches include biomedical experimentation, high-throughput technology, clinical trials, systematic reviews, meta-analysis, sampled surveys, simulation, data curation, statistics, omics, translational medicine, and integrative methodologies. Chinese Medicine is a credible channel to communicate unbiased scientific data, information, and knowledge in Chinese medicine among researchers, clinicians, academics, and students in Chinese medicine and other scientific disciplines of medicine.