Low-Frequency Deep Brain Stimulation in Non-Rapid Eye Movement Sleep Modifies Memory Retention in Parkinson's Disease.

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY Movement Disorders Pub Date : 2024-11-21 DOI:10.1002/mds.30064

Damian M Herz, Jenny Blech, Yaroslav Winter, Gabriel Gonzalez-Escamilla, Sergiu Groppa

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Abstract

Background and objective: Memory impairment is a frequent and debilitating symptom in neurodegenerative disorders. The objective of this study was to provide proof-of-principle that deep brain stimulation during sleep can modify memory consolidation in people with Parkinson's disease depending on the stimulation frequency that is applied.

Methods: Twenty-four patients with Parkinson's disease who were treated with deep brain stimulation of the subthalamic nucleus were included in this single-blind pilot study. Six patients had to be excluded because of insomnia on the night of testing. Patients were randomized (1:1 ratio) to receiving either low frequency deep brain stimulation (4 Hz) or clinically used high frequency deep brain stimulation (130 Hz) during early non-rapid eye movement (NREM) sleep. The main outcome measure was overnight memory retention as measured by a validated declarative memory task.

Results: Patients receiving low frequency deep brain stimulation during early NREM sleep (n = 9, 4 females, mean age 61.1 ± 4.3 years) showed improved overnight memory retention (z = 2.549, P = 0.011). Patients receiving clinically used high frequency deep brain stimulation (n = 9, 2 females, mean age 62.2 ± 7.1) did not show any improvement (z = 1.023, P = 0.306) leading to a significant difference between groups (z = 2.214, P = 0.027). Stronger improvement in memory function was correlated with increased cortical low frequency activity after low frequency deep brain stimulation as measured by electroencephalography (ρ = 0.711, P = 0.037).

Conclusion: These results provide proof-of-principle that memory can be modulated by frequency-specific deep brain stimulation during sleep. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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非快速眼动睡眠中的低频深层脑刺激可改变帕金森病患者的记忆保持能力

背景和目的：记忆障碍是神经退行性疾病中经常出现的一种使人衰弱的症状。本研究旨在提供原理性证据，证明睡眠期间的深部脑刺激可改变帕金森病患者的记忆巩固，具体取决于所使用的刺激频率：这项单盲试验研究共纳入了 24 名接受眼下核深部脑刺激治疗的帕金森病患者。有六名患者因测试当晚失眠而被排除在外。患者被随机分配（1:1 比例），在早期非快速眼动（NREM）睡眠期间接受低频深部脑刺激（4 Hz）或临床常用的高频深部脑刺激（130 Hz）。主要结果是通过一项有效的陈述性记忆任务测量患者的隔夜记忆保持率：结果：在早期非快速眼动睡眠中接受低频深部脑刺激的患者（n = 9，4 名女性，平均年龄为 61.1 ± 4.3 岁）的隔夜记忆保持率有所提高（z = 2.549，P = 0.011）。接受临床使用的高频深部脑刺激的患者（9 人，2 名女性，平均年龄（62.2 ± 7.1）岁）没有任何改善（z = 1.023，P = 0.306），组间差异显著（z = 2.214，P = 0.027）。通过脑电图测量，记忆功能的显著改善与低频深部脑刺激后皮层低频活动的增加相关（ρ = 0.711，P = 0.037）：这些结果提供了一个原则性证明，即在睡眠期间，特定频率的深部脑刺激可以调节记忆。© 2024 The Author(s).运动障碍》由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.