Exosome-mediated Transfer of lncRNA in Liver Associated Diseases; Uncovered Truths.

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Cell Biochemistry and Biophysics Pub Date : 2024-11-20 DOI:10.1007/s12013-024-01617-x

Raed Obaid Saleh, Hamad Ali Hamad, Maryam Abdulrahman Najim, Soumya V Menon, Mandeep Kaur, G V Sivaprasad, Mohammad Abohassan, Wen-Tau Juan, Beneen Husseen, Yasser Fakri Mustafa

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Abstract

Exosomes are extracellular vesicles with a diameter ranging from 40 to 160 nm. They are produced by hepatocytes, cholangiocytes, hepatic stellate cells (HSCs), liver sinusoidal endothelial cells (LSECs) and Kupffer cells in liver tissue. The secretion of exosomes might vary in quantity and composition in reaction to multiple triggers and various stages of disease. They transport various payloads, such as proteins, DNAs, and RNAs, and enable cell interaction to regulate myriad physiological and pathological processes in liver tissue. Long non-coding RNAs (lncRNAs) are a crucial component of exosomes with an excellent capability to regulate multiple cellular activities such as differentiation, development, metabolism, proliferation, apoptosis, and activation. With the advancements in transcriptomic and genomic study methods and database management technology, the functions and mechanisms of exosomal lncRNAs in liver diseases have been well-studied. This article delves into the detailed role of exosomal lncRNAs in liver disease onset and progression, ranging from hepatocellular carcinoma (HCC) to liver fibrosis drug-induced liver damage (DILI) and steatotic liver diseases.

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外泌体介导的 lncRNA 在肝脏相关疾病中的转移；揭秘真相。

外泌体是一种细胞外囊泡，直径在 40 到 160 纳米之间。它们由肝脏组织中的肝细胞、胆管细胞、肝星状细胞（HSCs）、肝窦状内皮细胞（LSECs）和 Kupffer 细胞产生。外泌体的分泌数量和组成可能会因多种诱因和疾病的不同阶段而变化。外泌体可运输蛋白质、DNA 和 RNA 等各种有效载荷，使细胞相互作用，调节肝组织中的各种生理和病理过程。长非编码RNA（lncRNA）是外泌体的重要组成部分，具有调节分化、发育、代谢、增殖、凋亡和活化等多种细胞活动的卓越能力。随着转录组和基因组研究方法以及数据库管理技术的进步，外泌体 lncRNA 在肝脏疾病中的功能和机制已得到了深入研究。本文详细探讨了外泌体 lncRNA 在肝脏疾病（从肝细胞癌（HCC）到肝纤维化药物性肝损伤（DILI）和脂肪肝）的发生和发展中的作用。

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来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.