A cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophrenia.

IF 3.4 2区医学 Q2 PSYCHIATRY BMC Psychiatry Pub Date : 2024-11-20 DOI:10.1186/s12888-024-06277-y

Huan Yu, Rui Li, Xue-Jun Liang, Wen-Mao Yang, Lin Guo, Ling Liu, Qing-Rong R Tan, Zheng-Wu Peng

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Abstract

Background: Major depressive disorder (MDD) and schizophrenia (SCH) are common and severe mental disorders that are mainly diagnosed depending on the subjective identification by psychiatrists. Finding potential objective biomarkers that can distinguish these two diseases is still meaningful.

Methods: In the present study, we investigate the differences in plasma inflammatory cytokines and short-chain fatty acids (SCFAs) among patients with MDD (n = 24) and SCH (n = 24), and gender- and age-matched healthy controls (HC, n = 27) and identify potential plasma biomarkers.

Results: We found that the concentrations of pro-inflammatory cytokines were increased, whereas the anti-inflammatory cytokines were decreased in both MDD and SCH. Meanwhile, except for an increase in 4-Methylvaleric acid, other SCFAs with statistical differences were reduced in both MDD and SCH. Moreover, potential biomarker panels were developed that can effectively discriminate MDD from HC (AUC = 0.997), SCH from HC (AUC = 0.999), and from each other (MDD from SCH, AUC = 0.983).

Conclusions: These data suggest that alterations in plasma cytokines and SCFAs might be one of the potential features for distinguishing MDD and SCH.

Trial registration: Chinese Clinical Trial Registry: ChiCTR2100051243, registration date: 2021/09/16.

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一项关于抑郁症和精神分裂症患者血浆炎症细胞因子和短链脂肪酸比较的横断面研究。

背景：重度抑郁障碍（MDD）和精神分裂症（SCH）是常见的严重精神障碍，其诊断主要依靠精神科医生的主观认定。寻找能够区分这两种疾病的潜在客观生物标志物仍然很有意义：在本研究中，我们调查了 MDD（24 人）和 SCH（24 人）患者与性别和年龄匹配的健康对照组（HC，27 人）之间血浆炎症细胞因子和短链脂肪酸（SCFAs）的差异，并确定了潜在的血浆生物标志物：结果：我们发现，在 MDD 和 SCH 患者中，促炎细胞因子的浓度升高，而抗炎细胞因子的浓度降低。同时，除 4-甲基戊酸增加外，其他具有统计学差异的 SCFAs 在 MDD 和 SCH 中均减少。此外，研究人员还发现了一些潜在的生物标记物，这些标记物能有效区分 MDD 和 HC（AUC = 0.997）、SCH 和 HC（AUC = 0.999）以及彼此（MDD 和 SCH，AUC = 0.983）：这些数据表明，血浆细胞因子和SCFAs的变化可能是区分MDD和SCH的潜在特征之一：试验注册：中国临床试验注册中心：试验注册：中国临床试验注册中心：ChiCTR2100051243，注册日期：2021/09/16。

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来源期刊

BMC Psychiatry 医学-精神病学

CiteScore

5.90

自引率

4.50%

发文量

716

审稿时长

3-6 weeks

期刊介绍： BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.