The Atopic Dermatitis Control Tool: Adaptation and Content Validation for Children and Caregivers of Children with Atopic Dermatitis.

IF 3.5 3区医学 Q1 DERMATOLOGY Dermatology and Therapy Pub Date : 2024-11-21 DOI:10.1007/s13555-024-01289-8

Chien-Chia Chuang, David M Pariser, Eric Simpson, Jennifer Dine, Michelle Brown, Sheri Fehnel, Zhixiao Wang

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Abstract

Introduction: The Atopic Dermatitis Control Tool (ADCT) assesses six concepts regarding patient-perceived control of atopic dermatitis (AD) in adults and adolescents with AD. This study aimed to develop two modified ADCT versions, one for children with AD aged 8-11 years and another for caregivers of children with AD aged 6 months to 11 years.

Methods: Following the US Food and Drug Administration patient-reported outcomes guidance, the ADCT was modified to produce draft Child and Caregiver ADCT versions, maintaining the original six concepts. The instruments were refined and finalized through an iterative process using input from children with AD and caregivers of children with AD via qualitative interviews. Inclusion criteria were clinician diagnosis of AD, prescription treatment use in the past 3 months, and itching/scratching or rash in the past month. Interviews consisted of concept elicitation to identify perceptions of AD control and cognitive debriefing to test and refine the ADCT items.

Results: In total, 19 children (mean age 9.2 years, 74% male) and 17 caregivers (mean age 36.3 years, 100% female) were interviewed. During concept elicitation, children and caregivers reported similar symptoms and described the cycling and unpredictability of AD. Most participants reported that daily activities were impacted negatively by AD symptoms. The concept of AD control resonated with children and caregivers, and respondents were able to describe their experiences related to AD symptom severity. Children were unfamiliar with the term AD, so the Child ADCT version was named the Child Eczema Control Tool (ECT). Children and caregivers both reported that the instruments assessed relevant concepts, comprehensively measured AD control, and demonstrated content and face validity.

Conclusions: The Child ECT and Caregiver ADCT were developed and qualitatively validated for assessing AD control in patients aged 6 months to 11 years and may offer simple ways to assess disease control and optimize treatment decisions. Video Abstract.

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特应性皮炎控制工具：特应性皮炎控制工具：针对儿童和特应性皮炎儿童护理者的改编和内容验证。

简介：特应性皮炎控制工具（ADCT）用于评估成人和青少年特应性皮炎患者对特应性皮炎（AD）控制的六个概念。本研究旨在开发两种经过修改的 ADCT 版本，一种适用于 8-11 岁的特应性皮炎儿童，另一种适用于 6 个月至 11 岁特应性皮炎儿童的看护者：方法：根据美国食品和药物管理局的患者报告结果指南，对 ADCT 进行了修改，在保留原有六个概念的基础上，编写了儿童和护理人员 ADCT 草案。通过定性访谈听取注意力缺失症儿童和注意力缺失症儿童照护者的意见，对工具进行反复改进并最终定稿。纳入标准为临床医生诊断为注意力缺失症、过去 3 个月内使用过处方治疗、过去 1 个月内出现过瘙痒/抓挠或皮疹。访谈包括概念激发，以确定对注意力缺失症控制的看法，以及认知汇报，以测试和完善注意力缺失症控制项目：共有 19 名儿童（平均年龄 9.2 岁，74% 为男性）和 17 名护理人员（平均年龄 36.3 岁，100% 为女性）接受了访谈。在概念激发过程中，儿童和照护者报告了相似的症状，并描述了注意力缺失症的周期性和不可预测性。大多数参与者表示，注意力缺失症症状对日常活动造成了负面影响。注意力缺失症控制的概念引起了儿童和照护者的共鸣，受访者能够描述他们与注意力缺失症症状严重程度相关的经历。儿童对 AD 一词并不熟悉，因此儿童 ADCT 版本被命名为儿童湿疹控制工具 (ECT)。儿童和护理人员均表示，这些工具评估了相关概念，全面衡量了AD控制能力，并显示出内容和表面效度：儿童湿疹控制工具 (Child ECT) 和护理者湿疹控制工具 (Caregiver ADCT) 是为评估 6 个月至 11 岁患者的湿疹控制情况而开发并经过定性验证的，可为评估疾病控制情况和优化治疗决策提供简单的方法。视频摘要

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来源期刊

Dermatology and Therapy Medicine-Dermatology

CiteScore

6.00

自引率

8.80%

发文量

187

审稿时长

6 weeks

期刊介绍： Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.