Sex Differences in Metabolic Disorders of Aging and Obesity in People with HIV.

IF 3.7 2区医学 Q2 INFECTIOUS DISEASES Current HIV/AIDS Reports Pub Date : 2024-11-21 DOI:10.1007/s11904-024-00711-2

Jessica A Alvarez, Chin-An Yang, Victoria Ojuri, Kahsavyah Buckley, Brahmchetna Bedi, Joffi Musonge-Effoe, Adaiah Soibi-Harry, Cecile D Lahiri

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Abstract

Purpose of review: As advances in antiretroviral therapy for people with HIV (PWH) have prolonged lifespans, prevalence of aging and obesity related metabolic disorders have increased. The purpose of this review is to summarize recent research assessing sex differences in metabolic disorders among PWH, including weight gain/obesity, steatotic liver disease, insulin resistance/diabetes, dyslipidemia, bone loss/osteoporosis, and sarcopenia.

Recent findings: A growing body of evidence shows that women with HIV are at increased risk of developing metabolic disorders compared to men, including body weight gain and obesity, type 2 diabetes mellitus, dyslipidemia, bone loss, and sarcopenia, while men with HIV are at higher risk for hepatosteatosis and hepatic fibrosis. Future work should prioritize the adequate representation of women in HIV clinical studies. Understanding sex-specific mechanisms underlying metabolic dysfunction in PWH is imperative so that interventions can be developed to address a growing global epidemic of metabolic diseases.

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艾滋病病毒感染者衰老代谢紊乱和肥胖的性别差异。

综述的目的：随着艾滋病病毒感染者（PWH）抗逆转录病毒疗法的发展，他们的寿命延长了，但与衰老和肥胖相关的代谢紊乱的发病率也增加了。本综述旨在总结最近的研究，评估艾滋病病毒感染者代谢紊乱的性别差异，包括体重增加/肥胖、脂肪肝、胰岛素抵抗/糖尿病、血脂异常、骨质流失/骨质疏松症和肌肉疏松症：越来越多的证据表明，与男性相比，女性艾滋病病毒感染者患代谢紊乱的风险更高，包括体重增加和肥胖、2 型糖尿病、血脂异常、骨质疏松和肌肉疏松症，而男性艾滋病病毒感染者患肝硬变和肝纤维化的风险更高。未来的工作应优先考虑女性在艾滋病临床研究中的充分代表性。了解艾滋病病毒感染者代谢功能障碍的性别特异性机制势在必行，这样才能制定干预措施，应对全球日益流行的代谢性疾病。

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来源期刊

Current HIV/AIDS Reports INFECTIOUS DISEASES-

CiteScore

8.10

自引率

2.20%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.