Characterization of changes in the resting-state intrinsic network in patients with diabetic peripheral neuropathy.

IF 3.8 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Scientific Reports Pub Date : 2024-11-21 DOI:10.1038/s41598-024-80216-5

Dongsheng Zhang, Yang Huang, Yitong Guan, Xiaoling Zhang, Peichun Pan, Xuejiao Yan, Xiaoyan Lei, Min Tang, Kai Ai, Jie Gao

{"title":"Characterization of changes in the resting-state intrinsic network in patients with diabetic peripheral neuropathy.","authors":"Dongsheng Zhang, Yang Huang, Yitong Guan, Xiaoling Zhang, Peichun Pan, Xuejiao Yan, Xiaoyan Lei, Min Tang, Kai Ai, Jie Gao","doi":"10.1038/s41598-024-80216-5","DOIUrl":null,"url":null,"abstract":"<p><p>Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes mellitus (T2DM) and is often accompanied by a variety of cognitive and emotional deficits, but the neurologic mechanisms underlying these deficits have not been fully elucidated. Therefore, this study aimed to use independent component analysis to explore the changes in the characteristics within the intrinsic network and to reveal patterns of interactions between networks in patients with DPN. Forty-one patients with T2DM who showed DPN, 37 patients with T2DM who did not show DPN (NDPN group), and 43 healthy controls (HC) underwent a neuropsychological assessment and resting-state functional magnetic resonance imaging examinations to examine the patterns of intra- and inter-network variations in the patients with T2DM at different clinical stages (with and without DPN). The relationships of intra- and inter-network functional connectivity (FC) with clinical/cognitive variables were also examined. In comparison with the NDPN group and HC, patients with DPN showed decreased FC within the visual network and sensorimotor network (SMN). Moreover, in comparison with the HC group, patients with DPN showed decreased FC within the anterior default mode network and increased FC within the basal ganglia network. Inter-network analysis showed decreased FC between the SMN and salience network in patients with DPN relative to the NDPN and HC groups. The decreased FC within the bilateral paracentral lobule (BA 6) of SMN was associated with Color Trails Test part 1 scores (r = -0.302, P = 0.007) and disease duration (r = -0.328, P = 0.003) in all patients with T2DM. In conclusion, the results revealed that patients with DPN have abnormal FC in multiple resting-state intrinsic networks in addition to the SMN, and that decreased FC between the SMN and salience network may be involved in the neural basis of abnormal sensorimotor function in patients with DPN.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28809"},"PeriodicalIF":3.8000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scientific Reports","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1038/s41598-024-80216-5","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes mellitus (T2DM) and is often accompanied by a variety of cognitive and emotional deficits, but the neurologic mechanisms underlying these deficits have not been fully elucidated. Therefore, this study aimed to use independent component analysis to explore the changes in the characteristics within the intrinsic network and to reveal patterns of interactions between networks in patients with DPN. Forty-one patients with T2DM who showed DPN, 37 patients with T2DM who did not show DPN (NDPN group), and 43 healthy controls (HC) underwent a neuropsychological assessment and resting-state functional magnetic resonance imaging examinations to examine the patterns of intra- and inter-network variations in the patients with T2DM at different clinical stages (with and without DPN). The relationships of intra- and inter-network functional connectivity (FC) with clinical/cognitive variables were also examined. In comparison with the NDPN group and HC, patients with DPN showed decreased FC within the visual network and sensorimotor network (SMN). Moreover, in comparison with the HC group, patients with DPN showed decreased FC within the anterior default mode network and increased FC within the basal ganglia network. Inter-network analysis showed decreased FC between the SMN and salience network in patients with DPN relative to the NDPN and HC groups. The decreased FC within the bilateral paracentral lobule (BA 6) of SMN was associated with Color Trails Test part 1 scores (r = -0.302, P = 0.007) and disease duration (r = -0.328, P = 0.003) in all patients with T2DM. In conclusion, the results revealed that patients with DPN have abnormal FC in multiple resting-state intrinsic networks in addition to the SMN, and that decreased FC between the SMN and salience network may be involved in the neural basis of abnormal sensorimotor function in patients with DPN.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

糖尿病周围神经病变患者静息态固有网络变化的特征。

糖尿病周围神经病变（DPN）是 2 型糖尿病（T2DM）最常见的并发症，通常伴有各种认知和情感障碍，但这些障碍背后的神经机制尚未完全阐明。因此，本研究旨在使用独立成分分析法探讨 DPN 患者内在网络特征的变化，并揭示网络之间的相互作用模式。41名出现DPN的T2DM患者、37名未出现DPN的T2DM患者（NDPN组）和43名健康对照组（HC）接受了神经心理评估和静息态功能磁共振成像检查，以研究T2DM患者在不同临床阶段（出现和未出现DPN）的网络内和网络间的变化模式。研究还探讨了网络内和网络间功能连接（FC）与临床/认知变量的关系。与NDPN组和HC组相比，DPN患者在视觉网络和感觉运动网络（SMN）内的功能连接性降低。此外，与 HC 组相比，DPN 患者在前部默认模式网络中的 FC 值降低，而在基底节网络中的 FC 值升高。网络间分析显示，相对于NDPN组和HC组，DPN患者的SMN和显著性网络间的FC降低了。在所有T2DM患者中，SMN双侧旁中央小叶（BA 6）内FC的降低与颜色轨迹测试第一部分得分（r = -0.302，P = 0.007）和病程（r = -0.328，P = 0.003）相关。总之，研究结果表明，DPN患者除SMN外，多个静息态固有网络的FC也存在异常，SMN与显著性网络之间FC的降低可能与DPN患者感觉运动功能异常的神经基础有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

期刊介绍： We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.