Biomimetic Materials for Antibacterial Applications

IF 13 2区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Small Pub Date : 2024-11-22 DOI:10.1002/smll.202408543
Junjie Zhang, Heng Dong, Bing Liu, Dongliang Yang
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Abstract

The rise of antibiotic resistance poses a critical threat to global health, necessitating the development of novel antibacterial strategies to mitigate this growing challenge. Biomimetic materials, inspired by natural biological systems, have emerged as a promising solution in this context. These materials, by mimicking biological entities such as plants, animals, cells, viruses, and enzymes, offer innovative approaches to combat bacterial infections effectively. This review delves into the integration of biomimicry with materials science to develop antibacterial agents that are not only effective but also biocompatible and less likely to induce resistance. The study explores the design and function of various biomimetic antibacterial materials, highlighting their therapeutic potential in anti-infection applications. Further, the study provides a comprehensive summary of recent advancements in this field, illustrating how these materials have been engineered to enhance their efficacy and safety. The review also discusses the critical challenges facing the transition of these biomimetic strategies from the laboratory to clinical settings, such as scalability, cost-effectiveness, and long-term stability. Lastly, the study discusses the vast opportunities that biomimetic materials hold for the future of antibacterial therapy, suggesting that continued research and multidisciplinary collaboration will be essential to realize their full potential.

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用于抗菌应用的仿生材料
抗生素耐药性的增加对全球健康构成了严重威胁,因此有必要开发新型抗菌策略,以缓解这一日益严峻的挑战。在此背景下,受自然生物系统启发的仿生材料成为一种前景广阔的解决方案。这些材料通过模仿植物、动物、细胞、病毒和酶等生物实体,提供了有效对抗细菌感染的创新方法。本综述深入探讨了如何将生物仿生学与材料科学相结合,开发出不仅有效,而且具有生物兼容性、不易产生抗药性的抗菌剂。研究探讨了各种生物仿生抗菌材料的设计和功能,强调了它们在抗感染应用中的治疗潜力。此外,该研究还全面总结了这一领域的最新进展,说明了这些材料是如何通过工程设计来提高其功效和安全性的。综述还讨论了这些生物仿生策略从实验室过渡到临床环境所面临的关键挑战,如可扩展性、成本效益和长期稳定性。最后,研究还讨论了生物仿生材料为未来抗菌治疗带来的巨大机遇,并指出持续研究和多学科合作对于充分发挥生物仿生材料的潜力至关重要。
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来源期刊
Small
Small 工程技术-材料科学:综合
CiteScore
17.70
自引率
3.80%
发文量
1830
审稿时长
2.1 months
期刊介绍: Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.
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