Raphaël Pronovost, Mathis Rion, Nikolaos Tzouras, Jean-François Paquin, Steven P Nolan
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引用次数: 0
Abstract
The gold-catalyzed hydrofluorination of terminal alkynes is reported. The salient features of this study showcase the use of potassium bifluoride, KHF2, as the fluorinating agent in conjunction with a fluorinated solvent, hexafluoroisopropanol. The reaction is mediated by a well-defined precursor, [Au(IPr)(OH)] with an acid activator. A wide range of functionalized terminal alkynes can be converted to the corresponding monofluoroalkenes in up to 97% yield.
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