Helicobacter pylori Infection in Children: To Eradicate or Not to Eradicate?

IF 4.3 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Helicobacter Pub Date : 2024-11-22 DOI:10.1111/hel.70002

Marco Manfredi, Madhur Ravikumara

引用次数: 0

Abstract

Helicobacter pylori infection is usually acquired during childhood and represents one of the most common infections in humans. It is well known that H. pylori has belonged to humankind for hundreds of thousands of years and it accompanied the human migration from Africa. The adult international guidelines recommend treating all infected patients as H. pylori was classified among the first-class human carcinogens by the WHO in 1994 and it is one of the main factors involved in the development of gastric cancer. Conversely, the pediatric international guidelines are more restrictive in recommending the eradication of the infection in children. Although many studies have shown evidence regarding the pathological role of H. pylori regardless of the age of the infected patients, many others have highlighted its protective/positive role in several extra-gastric diseases in children. In this review, both points of view regarding the eradication in children are critically analyzed.

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儿童幽门螺杆菌感染：根除还是不根除？

幽门螺杆菌感染通常发生在儿童时期，是人类最常见的感染之一。众所周知，幽门螺杆菌属于人类已有数十万年的历史，它伴随着人类从非洲迁徙而来。由于幽门螺杆菌在 1994 年被世界卫生组织列为人类一级致癌物，是导致胃癌的主要因素之一，因此成人国际指南建议对所有感染者进行治疗。相反，国际儿科指南则更严格地建议根除儿童感染的幽门螺杆菌。尽管许多研究表明，幽门螺杆菌的病理作用与受感染患者的年龄无关，但也有许多其他研究强调了幽门螺杆菌在儿童多种胃外疾病中的保护/阳性作用。在这篇综述中，我们将对有关根除儿童幽门螺杆菌的两种观点进行批判性分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Helicobacter 医学-微生物学

CiteScore

8.40

自引率

9.10%

发文量

审稿时长

2 months

期刊介绍： Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.