首页 > 最新文献

Helicobacter最新文献

英文 中文
Helicobacter pylori Infection in Children: To Eradicate or Not to Eradicate? 儿童幽门螺杆菌感染:根除还是不根除?
IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-22 DOI: 10.1111/hel.70002
Marco Manfredi, Madhur Ravikumara

Helicobacter pylori infection is usually acquired during childhood and represents one of the most common infections in humans. It is well known that H. pylori has belonged to humankind for hundreds of thousands of years and it accompanied the human migration from Africa. The adult international guidelines recommend treating all infected patients as H. pylori was classified among the first-class human carcinogens by the WHO in 1994 and it is one of the main factors involved in the development of gastric cancer. Conversely, the pediatric international guidelines are more restrictive in recommending the eradication of the infection in children. Although many studies have shown evidence regarding the pathological role of H. pylori regardless of the age of the infected patients, many others have highlighted its protective/positive role in several extra-gastric diseases in children. In this review, both points of view regarding the eradication in children are critically analyzed.

幽门螺杆菌感染通常发生在儿童时期,是人类最常见的感染之一。众所周知,幽门螺杆菌属于人类已有数十万年的历史,它伴随着人类从非洲迁徙而来。由于幽门螺杆菌在 1994 年被世界卫生组织列为人类一级致癌物,是导致胃癌的主要因素之一,因此成人国际指南建议对所有感染者进行治疗。相反,国际儿科指南则更严格地建议根除儿童感染的幽门螺杆菌。尽管许多研究表明,幽门螺杆菌的病理作用与受感染患者的年龄无关,但也有许多其他研究强调了幽门螺杆菌在儿童多种胃外疾病中的保护/阳性作用。在这篇综述中,我们将对有关根除儿童幽门螺杆菌的两种观点进行批判性分析。
{"title":"Helicobacter pylori Infection in Children: To Eradicate or Not to Eradicate?","authors":"Marco Manfredi,&nbsp;Madhur Ravikumara","doi":"10.1111/hel.70002","DOIUrl":"https://doi.org/10.1111/hel.70002","url":null,"abstract":"<div>\u0000 \u0000 <p><i>Helicobacter pylori</i> infection is usually acquired during childhood and represents one of the most common infections in humans. It is well known that <i>H. pylori</i> has belonged to humankind for hundreds of thousands of years and it accompanied the human migration from Africa. The adult international guidelines recommend treating all infected patients as <i>H. pylori</i> was classified among the first-class human carcinogens by the WHO in 1994 and it is one of the main factors involved in the development of gastric cancer. Conversely, the pediatric international guidelines are more restrictive in recommending the eradication of the infection in children. Although many studies have shown evidence regarding the pathological role of <i>H. pylori</i> regardless of the age of the infected patients, many others have highlighted its protective/positive role in several extra-gastric diseases in children. In this review, both points of view regarding the eradication in children are critically analyzed.</p>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"29 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicobacter pylori Eradication Therapy and the Risk of Colorectal Cancer: A Population-Based Nationwide Cohort Study in Sweden 幽门螺杆菌根除疗法与结直肠癌风险:瑞典基于人口的全国队列研究
IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-20 DOI: 10.1111/hel.70001
Qing Liu, Omid Sadr-Azodi, Lars Engstrand, Katja Fall, Nele Brusselaers

Background

Helicobacter pylori (H. pylori) is an established gastric carcinogen, also associated with an increased risk of colorectal cancer. Therefore, we suspected that H. pylori eradication lowers the risk of colorectal cancer.

Material and Methods

We assessed if H. pylori eradication therapy is associated with a reduced risk of colorectal adenocarcinoma in a population-based nationwide cohort study. This study included all Swedish adults with at least one recorded H. pylori eradication episode between July 2005 and December 2012, based on the high-quality Swedish health registries. Colorectal adenocarcinoma risks were compared to the Swedish background population, presented as standardized incidence ratios (SIRs) and 95% confidence intervals (CIs), accounting for age, sex, calendar period, tumor location (left or right sided), stage, and number of eradication episodes, from 1 year after eradication and onward.

Results

Among 80,381 individuals receiving H. pylori eradication therapy (average follow-up 4.1 years), 282 were diagnosed with colorectal cancer (97.2% adenocarcinoma). Overall, H. pylori eradication was associated with an elevated risk of colorectal adenocarcinoma (SIR 1.27, 95% CI: 1.12–1.43). The colorectal adenocarcinoma risk was increased 1–2 years after eradication (SIR 1.42, 95% CI: 1.17–1.72), then decreased 2–4 years (SIR 0.80, 95% CI: 0.65–0.98) and 4–6 years (SIR 0.76, 95% CI: 0.57–0.99), yet not ≥ 6 years (SIR 1.36, 95% CI: 0.78–2.21) after eradication compared to the general population. Overall, right-sided (SIR 1.47, 95% CI: 1.21–1.76) and left-sided (SIR 1.35, 95% CI: 1.09–1.67) colon adenocarcinomas risks were higher among eradicated individuals than the general population.

Conclusion

H. pylori eradication was not associated with a clear and consistent reduction of colorectal cancer in our Swedish cohort.

背景幽门螺杆菌(H. pylori)是一种公认的胃癌致癌物,也与结直肠癌风险增加有关。因此,我们怀疑根除幽门螺杆菌可降低结直肠癌的风险。 材料和方法 我们在一项全国性人群队列研究中评估了根除幽门螺杆菌治疗是否与结直肠腺癌风险的降低有关。这项研究纳入了 2005 年 7 月至 2012 年 12 月期间至少有一次幽门螺杆菌根除病例记录的所有瑞典成年人,其依据是高质量的瑞典健康登记。在考虑年龄、性别、日历时间、肿瘤位置(左侧或右侧)、分期和根除次数的情况下,将根除后1年及以后的结直肠腺癌风险与瑞典背景人群进行比较,并以标准化发病率比(SIR)和95%置信区间(CI)表示。 结果 在接受幽门螺杆菌根除治疗的 80,381 人中(平均随访 4.1 年),有 282 人被确诊为结直肠癌(97.2% 为腺癌)。总体而言,根除幽门螺杆菌与结直肠腺癌风险升高有关(SIR 1.27,95% CI:1.12-1.43)。与普通人群相比,根除幽门螺杆菌后 1-2 年的结直肠腺癌风险增加(SIR 1.42,95% CI:1.17-1.72),2-4 年(SIR 0.80,95% CI:0.65-0.98)和 4-6 年(SIR 0.76,95% CI:0.57-0.99)的风险降低,但根除后≥ 6 年的风险没有增加(SIR 1.36,95% CI:0.78-2.21)。总体而言,根除者患右侧(SIR 1.47,95% CI:1.21-1.76)和左侧(SIR 1.35,95% CI:1.09-1.67)结肠腺癌的风险高于普通人群。 结论 在我们的瑞典队列中,根除幽门螺杆菌与结直肠癌发病率的明显持续下降无关。
{"title":"Helicobacter pylori Eradication Therapy and the Risk of Colorectal Cancer: A Population-Based Nationwide Cohort Study in Sweden","authors":"Qing Liu,&nbsp;Omid Sadr-Azodi,&nbsp;Lars Engstrand,&nbsp;Katja Fall,&nbsp;Nele Brusselaers","doi":"10.1111/hel.70001","DOIUrl":"https://doi.org/10.1111/hel.70001","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p><i>Helicobacter pylori</i> (<i>H. pylori</i>) is an established gastric carcinogen, also associated with an increased risk of colorectal cancer. Therefore, we suspected that <i>H. pylori</i> eradication lowers the risk of colorectal cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>We assessed if <i>H. pylori</i> eradication therapy is associated with a reduced risk of colorectal adenocarcinoma in a population-based nationwide cohort study. This study included all Swedish adults with at least one recorded <i>H. pylori</i> eradication episode between July 2005 and December 2012, based on the high-quality Swedish health registries. Colorectal adenocarcinoma risks were compared to the Swedish background population, presented as standardized incidence ratios (SIRs) and 95% confidence intervals (CIs), accounting for age, sex, calendar period, tumor location (left or right sided), stage, and number of eradication episodes, from 1 year after eradication and onward.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 80,381 individuals receiving <i>H. pylori</i> eradication therapy (average follow-up 4.1 years), 282 were diagnosed with colorectal cancer (97.2% adenocarcinoma). Overall, <i>H. pylori</i> eradication was associated with an elevated risk of colorectal adenocarcinoma (SIR 1.27, 95% CI: 1.12–1.43). The colorectal adenocarcinoma risk was increased 1–2 years after eradication (SIR 1.42, 95% CI: 1.17–1.72), then decreased 2–4 years (SIR 0.80, 95% CI: 0.65–0.98) and 4–6 years (SIR 0.76, 95% CI: 0.57–0.99), yet not ≥ 6 years (SIR 1.36, 95% CI: 0.78–2.21) after eradication compared to the general population. Overall, right-sided (SIR 1.47, 95% CI: 1.21–1.76) and left-sided (SIR 1.35, 95% CI: 1.09–1.67) colon adenocarcinomas risks were higher among eradicated individuals than the general population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p><i>H. pylori</i> eradication was not associated with a clear and consistent reduction of colorectal cancer in our Swedish cohort.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"29 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/hel.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LCI's Diagnostic Performance for Gastric Cancer: A New Solution to Screening? LCI 的胃癌诊断性能:筛查新方案?
IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-13 DOI: 10.1111/hel.70000
Guilherme Nobre Nogueira
{"title":"LCI's Diagnostic Performance for Gastric Cancer: A New Solution to Screening?","authors":"Guilherme Nobre Nogueira","doi":"10.1111/hel.70000","DOIUrl":"10.1111/hel.70000","url":null,"abstract":"","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"29 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nationwide Trends in Helicobacter pylori Eradication Therapies in Korea: Impact of Guideline Updates on Treatment Practices 韩国全国幽门螺杆菌根除疗法的趋势:指南更新对治疗实践的影响。
IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-13 DOI: 10.1111/hel.13152
Byung Wook Jung, Yun Jin Kim, Chan Hyuk Park

Introduction

Helicobacter pylori infects over 50% of the global population, prompting the issuance of guidelines for effective diagnosis and treatment. However, research on guideline dissemination and adherence is limited. Therefore, we assessed the nationwide status of H. pylori eradication therapies in Korea before and after guideline updates.

Methods

Using data from the Korean National Health Insurance Service, this retrospective cohort study analyzed changes in H. pylori eradication therapies across three periods: Phase I (2006–2007), Phase II (2014–2015), and Phase III (2021–2022). It examined therapy regimens, confirmation tests, and retreatment rates.

Results

Among 1,657,746 patients included, the number undergoing eradication therapy increased across the phases (Phase I: 234,365; Phase II: 493,889; Phase III: 929,492). The use of conventional triple therapy declined from 96.1% in Phase I to 88.3% in Phase III, while non-bismuth and bismuth quadruple therapies increased to 6.8% and 3.3%, respectively, in Phase III. The proportion of patients following a 1-week regimen of conventional triple therapy decreased from 90.3% in Phase I to 54.2% in Phase III, while a 2-week regimen increased to 36.1% in Phase III. Confirmation testing within 1 year of therapy increased from 21.3% in Phase I to 43.0% in Phase III, whereas retreatment rates increased from 3.8% in Phase I to 8.8% in Phase III.

Conclusions

Guideline updates have influenced H. pylori eradication practices in Korea, leading to increased use of quadruple therapies with longer treatment durations. However, further improvements in confirmatory tests and retreatment following failed initial therapy are required.

导言:幽门螺杆菌感染了全球 50%以上的人口,因此发布了有效诊断和治疗指南。然而,有关指南传播和遵守情况的研究却很有限。因此,我们对指南更新前后韩国全国幽门螺杆菌根除疗法的状况进行了评估:这项回顾性队列研究利用韩国国民健康保险服务局的数据,分析了幽门螺杆菌根除疗法在三个时期的变化:第一阶段(2006-2007 年)、第二阶段(2014-2015 年)和第三阶段(2021-2022 年)。研究考察了治疗方案、确认试验和再治疗率:在纳入的 1,657,746 名患者中,接受根除疗法的人数在各阶段均有所增加(第一阶段:234,365 人;第二阶段:493,889 人;第三阶段:929,492 人)。常规三联疗法的使用率从第一阶段的 96.1% 下降到第三阶段的 88.3%,而非铋和铋四联疗法的使用率在第三阶段分别上升到 6.8% 和 3.3%。采用传统三联疗法1周疗法的患者比例从I期的90.3%降至III期的54.2%,而采用2周疗法的患者比例在III期增至36.1%。治疗一年内的确诊检测率从一期的21.3%增至三期的43.0%,而再治疗率从一期的3.8%增至三期的8.8%:结论:指南的更新对韩国根除幽门螺杆菌的实践产生了影响,导致四联疗法的使用增加,治疗时间延长。然而,还需要进一步改进确证检验和初始治疗失败后的再治疗。
{"title":"Nationwide Trends in Helicobacter pylori Eradication Therapies in Korea: Impact of Guideline Updates on Treatment Practices","authors":"Byung Wook Jung,&nbsp;Yun Jin Kim,&nbsp;Chan Hyuk Park","doi":"10.1111/hel.13152","DOIUrl":"10.1111/hel.13152","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p><i>Helicobacter pylori</i> infects over 50% of the global population, prompting the issuance of guidelines for effective diagnosis and treatment. However, research on guideline dissemination and adherence is limited. Therefore, we assessed the nationwide status of <i>H. pylori</i> eradication therapies in Korea before and after guideline updates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using data from the Korean National Health Insurance Service, this retrospective cohort study analyzed changes in <i>H. pylori</i> eradication therapies across three periods: Phase I (2006–2007), Phase II (2014–2015), and Phase III (2021–2022). It examined therapy regimens, confirmation tests, and retreatment rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 1,657,746 patients included, the number undergoing eradication therapy increased across the phases (Phase I: 234,365; Phase II: 493,889; Phase III: 929,492). The use of conventional triple therapy declined from 96.1% in Phase I to 88.3% in Phase III, while non-bismuth and bismuth quadruple therapies increased to 6.8% and 3.3%, respectively, in Phase III. The proportion of patients following a 1-week regimen of conventional triple therapy decreased from 90.3% in Phase I to 54.2% in Phase III, while a 2-week regimen increased to 36.1% in Phase III. Confirmation testing within 1 year of therapy increased from 21.3% in Phase I to 43.0% in Phase III, whereas retreatment rates increased from 3.8% in Phase I to 8.8% in Phase III.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Guideline updates have influenced <i>H. pylori</i> eradication practices in Korea, leading to increased use of quadruple therapies with longer treatment durations. However, further improvements in confirmatory tests and retreatment following failed initial therapy are required.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"29 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicobacter pylori Management in Africa: A Survey of Diagnostic, Treatment, and Related Resources 非洲的幽门螺杆菌管理:诊断、治疗及相关资源调查。
IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-13 DOI: 10.1111/hel.13153
Setshedi Mashiko, Stella Ifeanyi Smith, Ugiagbe Rose, Otegbayo Jesse Abiodun, Hyasinta Jaka, Onyekwere Charles, Nashidengo Abdulrashid, Kayamba Violet, Tshibangu-Kabamba Evariste, Ndububa Dennis, Gunturu Revathi, Lahbabi-Amrani Naima, Ajayi Abraham, Tolulope Funbi Jolaiya, Dieye Yakhya, Alboraie Mohamed, Ndip Roland

Background

Although Helicobacter pylori infection (H. pylori) prevalence in Africa has declined in the last decade, it remains concerningly high. H. pylori is asymptomatic in the majority of patients but is associated with significant morbidity and mortality in 10%–20%.

Materials and Methods

We conducted an online survey of 21 African countries, with the link distributed to members of the African Helicobacter Microbiota Study Group. The survey was completed by 562 respondents; the majority were from Nigeria (27.2%), South Africa (18.1%), Tanzania (17.6%), Egypt (16.9%), and Cameroon (14.2%).

Results

The most common reason for H. pylori testing was dyspepsia in 83.9% of the cases. Abnormal findings at gastroscopy (62.3%) and heartburn (61.7%) were also common indications. Stool antigen testing and histological examination of gastric biopsies using Giemsa were the two most used methods for H. pylori testing at 62.3% and 50.3%, respectively. Most respondents reported the use of standard clarithromycin-based triple therapy as first-line treatment for H. pylori infection.

Conclusion

This survey has demonstrated the diversity of practice and resource availability within the African continent. Several international guidelines exist on the management of H. pylori, but little data is available in Africa on how this condition is managed in every day clinical practice. There is an urgent need to formulate evidence-based and locally relevant practice guidelines on the African continent. In this context, the African Helicobacter and Microbiota study group was formed to coordinate efforts across the continent on H. pylori research to provide guidance on its management. This paper, therefore, aimed to evaluate the practice of H. pylori diagnostics and management, as well as related resources in representative countries in Africa, to facilitate the development of such guidelines.

背景:尽管幽门螺杆菌感染(H. pylori)在非洲的流行率在过去十年中有所下降,但仍然居高不下,令人担忧。幽门螺杆菌在大多数患者中是无症状的,但在 10%-20%的患者中与严重的发病率和死亡率有关:我们对 21 个非洲国家进行了在线调查,并向非洲幽门螺杆菌微生物群研究小组成员分发了链接。共有 562 名受访者完成了调查,其中大多数来自尼日利亚(27.2%)、南非(18.1%)、坦桑尼亚(17.6%)、埃及(16.9%)和喀麦隆(14.2%):幽门螺杆菌检测最常见的原因是消化不良,占 83.9%。胃镜检查发现异常(62.3%)和胃灼热(61.7%)也是常见原因。粪便抗原检测和使用革兰氏染色法进行胃活检组织学检查是幽门螺杆菌检测最常用的两种方法,分别占 62.3% 和 50.3%。大多数受访者表示,使用以克拉霉素为基础的标准三联疗法作为幽门螺杆菌感染的一线治疗方法:这项调查显示了非洲大陆实践和资源可用性的多样性。关于幽门螺杆菌的治疗,已有多项国际指南,但关于非洲在日常临床实践中如何治疗这种疾病的数据却很少。在非洲大陆,迫切需要制定以证据为基础、与当地情况相关的实践指南。在这种情况下,非洲幽门螺杆菌和微生物群研究小组成立了,目的是协调整个非洲大陆的幽门螺杆菌研究工作,为幽门螺杆菌的管理提供指导。因此,本文旨在评估非洲代表性国家的幽门螺杆菌诊断和管理实践以及相关资源,以促进此类指南的制定。
{"title":"Helicobacter pylori Management in Africa: A Survey of Diagnostic, Treatment, and Related Resources","authors":"Setshedi Mashiko,&nbsp;Stella Ifeanyi Smith,&nbsp;Ugiagbe Rose,&nbsp;Otegbayo Jesse Abiodun,&nbsp;Hyasinta Jaka,&nbsp;Onyekwere Charles,&nbsp;Nashidengo Abdulrashid,&nbsp;Kayamba Violet,&nbsp;Tshibangu-Kabamba Evariste,&nbsp;Ndububa Dennis,&nbsp;Gunturu Revathi,&nbsp;Lahbabi-Amrani Naima,&nbsp;Ajayi Abraham,&nbsp;Tolulope Funbi Jolaiya,&nbsp;Dieye Yakhya,&nbsp;Alboraie Mohamed,&nbsp;Ndip Roland","doi":"10.1111/hel.13153","DOIUrl":"10.1111/hel.13153","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although <i>Helicobacter pylori</i> infection (<i>H. pylori</i>) prevalence in Africa has declined in the last decade, it remains concerningly high. <i>H. pylori</i> is asymptomatic in the majority of patients but is associated with significant morbidity and mortality in 10%–20%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We conducted an online survey of 21 African countries, with the link distributed to members of the African Helicobacter Microbiota Study Group. The survey was completed by 562 respondents; the majority were from Nigeria (27.2%), South Africa (18.1%), Tanzania (17.6%), Egypt (16.9%), and Cameroon (14.2%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The most common reason for <i>H. pylori</i> testing was dyspepsia in 83.9% of the cases. Abnormal findings at gastroscopy (62.3%) and heartburn (61.7%) were also common indications. Stool antigen testing and histological examination of gastric biopsies using Giemsa were the two most used methods for <i>H. pylori</i> testing at 62.3% and 50.3%, respectively. Most respondents reported the use of standard clarithromycin-based triple therapy as first-line treatment for <i>H. pylori</i> infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This survey has demonstrated the diversity of practice and resource availability within the African continent. Several international guidelines exist on the management of <i>H. pylori</i>, but little data is available in Africa on how this condition is managed in every day clinical practice. There is an urgent need to formulate evidence-based and locally relevant practice guidelines on the African continent. In this context, the African Helicobacter and Microbiota study group was formed to coordinate efforts across the continent on <i>H. pylori</i> research to provide guidance on its management. This paper, therefore, aimed to evaluate the practice of <i>H. pylori</i> diagnostics and management, as well as related resources in representative countries in Africa, to facilitate the development of such guidelines.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"29 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Vonoprazan in Dual/Triple/Quadruple Regimens Both in First-Line and Rescue Therapy for Helicobacter pylori Eradication: A Systematic Review With Meta-Analysis 双联/三联/四联方案中伏诺派赞作为根除幽门螺杆菌一线疗法和救援疗法的有效性和安全性:带 Meta 分析的系统回顾。
IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-12 DOI: 10.1111/hel.13148
Belén Martínez Benito, Olga P. Nyssen, Javier P. Gisbert

Background

The efficacy of Helicobacter pylori (H. pylori) eradication therapies encompassing one or more antibiotics and a proton pump inhibitor (PPI) has lately decreased. Vonoprazan (VPZ), a potassium-competitive acid blocker, provides higher gastric acid suppression than PPIs. We performed a meta-analysis evaluating the efficacy and safety of VPZ in H. pylori eradication therapies.

Methods

Studies were searched in PubMed, Embase, and the Cochrane Library up to June 2023. Efficacy was evaluated by intention-to-treat analysis. Data were combined by meta-analyzing risk differences (RD). Heterogeneity was evaluated by subgrouping.

Results

Seventy-seven studies (24 randomized clinical trials) evaluated 44,162 patients (22,297 receiving VPZ and 21,865 PPIs). Overall VPZ efficacy was 88% (95% CI = 87%–90%): 86%, 88%, and 94% for dual/triple/quadruple-VPZ-containing therapies. VPZ efficacy was 87% (86%–89%) in first-line and 90% (87%–93%) in rescue therapy. VPZ performed better than PPIs in treatment-naïve patients (87% vs. 70%; RD = 0.13, 95% CI = 0.11–0.15) and when using triple regimens. No significant differences were observed in rescue and quadruple therapies. In patients with clarithromycin-resistant infection, VPZ-based therapies demonstrated an 81% efficacy (76%–85%), surpassing PPIs (76% vs. 40%; RD = 0.33, 95% CI = 0.24–0.43). For clarithromycin-susceptible strains, VPZ efficacy was 92% (89%–95%), similar to PPIs. VPZ adverse events rate was 19% (16%–21%), comparable to PPI-based regimens (18% vs. 13%, respectively; RD = 0.00, 95% CI = −0.01 to 0.02, p = 0.57).

Conclusions

The efficacy of VPZ-based regimens was over 85% in all treatment combinations. In treatment-naïve and clarithromycin-resistant patients, VPZ performed better than PPIs. In rescue therapy, in clarithromycin-susceptible patients or when quadruple regimens were prescribed, this advantage was not confirmed. Tolerability was similar in both regimens.

背景:幽门螺杆菌(H. pylori)根除疗法包括一种或多种抗生素和一种质子泵抑制剂(PPI),其疗效近来有所下降。与 PPIs 相比,钾竞争性胃酸阻滞剂 Vonoprazan(VPZ)能提供更强的胃酸抑制作用。我们进行了一项荟萃分析,评估了 VPZ 在根除幽门螺杆菌疗法中的有效性和安全性:我们在 PubMed、Embase 和 Cochrane 图书馆中检索了截至 2023 年 6 月的研究。通过意向治疗分析评估疗效。通过荟萃分析风险差异(RD)合并数据。通过分组对异质性进行评估:77项研究(24项随机临床试验)评估了44,162名患者(22,297人接受VPZ治疗,21,865人接受PPIs治疗)。VPZ的总体疗效为88%(95% CI = 87%-90%):含 VPZ 的双重/三重/四重疗法的疗效分别为 86%、88% 和 94%。VPZ在一线治疗中的有效率为87%(86%-89%),在抢救治疗中的有效率为90%(87%-93%)。VPZ 在治疗新患者(87% 对 70%;RD = 0.13,95% CI = 0.11-0.15)和使用三联疗法时的疗效优于 PPIs。在抢救疗法和四联疗法中未观察到明显差异。在克拉霉素耐药感染患者中,VPZ疗法的有效率为81%(76%-85%),超过了PPIs疗法(76% vs. 40%;RD = 0.33,95% CI = 0.24-0.43)。对于克拉霉素易感菌株,VPZ 的有效率为 92%(89%-95%),与 PPIs 相似。VPZ的不良反应率为19%(16%-21%),与基于PPI的治疗方案相当(分别为18% vs. 13%;RD = 0.00,95% CI = -0.01 to 0.02,p = 0.57):结论:以VPZ为基础的治疗方案在所有治疗组合中的有效率均超过85%。结论:在所有治疗组合中,以 VPZ 为基础的治疗方案的有效率超过 85%。在治疗无效和对克拉霉素耐药的患者中,VPZ 的疗效优于 PPIs。在抢救治疗、对克拉霉素敏感的患者或使用四联疗法时,这一优势并未得到证实。两种方案的耐受性相似。
{"title":"Efficacy and Safety of Vonoprazan in Dual/Triple/Quadruple Regimens Both in First-Line and Rescue Therapy for Helicobacter pylori Eradication: A Systematic Review With Meta-Analysis","authors":"Belén Martínez Benito,&nbsp;Olga P. Nyssen,&nbsp;Javier P. Gisbert","doi":"10.1111/hel.13148","DOIUrl":"10.1111/hel.13148","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The efficacy of <i>Helicobacter pylori</i> (<i>H. pylori</i>) eradication therapies encompassing one or more antibiotics and a proton pump inhibitor (PPI) has lately decreased. Vonoprazan (VPZ), a potassium-competitive acid blocker, provides higher gastric acid suppression than PPIs. We performed a meta-analysis evaluating the efficacy and safety of VPZ in <i>H. pylori</i> eradication therapies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Studies were searched in PubMed, Embase, and the Cochrane Library up to June 2023. Efficacy was evaluated by intention-to-treat analysis. Data were combined by meta-analyzing risk differences (RD). Heterogeneity was evaluated by subgrouping.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventy-seven studies (24 randomized clinical trials) evaluated 44,162 patients (22,297 receiving VPZ and 21,865 PPIs). Overall VPZ efficacy was 88% (95% CI = 87%–90%): 86%, 88%, and 94% for dual/triple/quadruple-VPZ-containing therapies. VPZ efficacy was 87% (86%–89%) in first-line and 90% (87%–93%) in rescue therapy. VPZ performed better than PPIs in treatment-naïve patients (87% vs. 70%; RD = 0.13, 95% CI = 0.11–0.15) and when using triple regimens. No significant differences were observed in rescue and quadruple therapies. In patients with clarithromycin-resistant infection, VPZ-based therapies demonstrated an 81% efficacy (76%–85%), surpassing PPIs (76% vs. 40%; RD = 0.33, 95% CI = 0.24–0.43). For clarithromycin-susceptible strains, VPZ efficacy was 92% (89%–95%), similar to PPIs. VPZ adverse events rate was 19% (16%–21%), comparable to PPI-based regimens (18% vs. 13%, respectively; RD = 0.00, 95% CI = −0.01 to 0.02, <i>p</i> = 0.57).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The efficacy of VPZ-based regimens was over 85% in all treatment combinations. In treatment-naïve and clarithromycin-resistant patients, VPZ performed better than PPIs. In rescue therapy, in clarithromycin-susceptible patients or when quadruple regimens were prescribed, this advantage was not confirmed. Tolerability was similar in both regimens.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"29 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tegoprazan-Amoxicillin Dual Therapy for Helicobacter pylori Eradication: A Prospective, Randomized, Multicenter Study in Fujian, China 替戈普拉赞-阿莫西林双重疗法根除幽门螺旋杆菌:中国福建的一项前瞻性、随机、多中心研究。
IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-10 DOI: 10.1111/hel.13151
Xueyan Lin, Huping Huang, Yijuan Liu, Yanling Zeng, Shiyun Lu, Xuefeng Xu, Yun Lin, Feng Qiu, Fangfang Cai, Jie Pan, Shaozhong Huang, Shaowei Lin, Aiping Lin, Zhihui Lin, Xueping Huang
<div> <section> <h3> Introduction</h3> <p>Few studies have investigated the efficacy and safety of tegoprazan-amoxicillin (TA) dual therapy for <i>Helicobacter pylori</i> eradication. We aim to evaluate the effectiveness and safety of different dosages of TA dual therapy for <i>H. pylori</i> eradication.</p> </section> <section> <h3> Methods</h3> <p>This prospective, randomized, open-label, multicenter study was conducted at four centers in Fujian, China. <i>H. pylori-</i>infective patients were randomized 1:1:1 to receive one of the following treatments: bismuth quadruple therapy (BQT, esomeprazole 20 mg twice daily + potassium bismuth citrate 240 mg twice daily + amoxicillin 1 g twice daily + clarithromycin 500 mg twice daily), tegoprazan-amoxicillin dual therapies (TA-qd, tegoprazan 50 mg once daily + amoxicillin 1 g thrice daily; TA-bid, tegoprazan 50 mg twice daily + amoxicillin 1 g thrice daily) for 14 days. The primary outcome was noninferiority in eradication rates of the different TA groups compared to the BQT group. Secondary outcomes encompassed an assessment of adverse reactions and clinical symptom relief. Additionally, exploratory outcomes were focused on the shifts in gut microbiota and a cost-effectiveness analysis.</p> </section> <section> <h3> Results</h3> <p>A total of 321 patients were enrolled. The eradication rates in the BQT group, TA-qd group, and TA-bid group were 85.05% (91/107), 85.98% (92/107), and 85.98% (92/107) in the intention-to-treat analysis (ITT) (BQT vs. TA-qd, 95% CI −8.50% to 10.36%, noninferiority <i>p</i> = 0.012; BQT vs. TA-bid, 95% CI −8.50% to 10.36%, noninferiority <i>p</i> = 0.012); 91.00% (91/100), 91.09% (92/101), and 92.93% (92/99) in the modified intention-to-treat analysis (mITT) (BQT vs. TA-qd, 95% CI −7.81% to 7.98%, noninferiority <i>p</i> = 0.006; BQT vs. TA-bid, 95% CI −5.62% to 9.48%, noninferiority <i>p</i> < 0.001); 90.81% (89/98), 91.00% (91/100), and 93.81% (91/97) in the per-protocol analysis (PP) (BQT vs. TA-qd, 95% CI −7.83% to 8.19%, noninferiority <i>p</i> = 0.006; BQT vs. TA-bid, 95% CI 4.46% to 10.46%, noninferiority <i>p</i> < 0.001). The incidence of adverse reactions in the TA-qd and TA-bid groups was significantly lower than in the BQT group (13.33%, 14.56%, and 27.18%, respectively; <i>p</i> = 0.017). The complete remissions of clinical symptoms for BQT, TA-qd, and TA-bid were 36.89%, 65.71%, and 68.93%, respectively, had significant differences (<i>p</i> < 0.001). Two weeks of TA therapy altered gut microbiota diversity and composition, but that recovered 4 weeks after discontinuation. The cost-effectiveness ratios (CERs) for BQT, TA-qd, and TA-bid were 1.85 CNY, 2.08 CNY, and 3.69 CNY, respectively.</p> </section>
简介:很少有研究探讨替戈普拉唑-阿莫西林(TA)双重疗法根除幽门螺杆菌的有效性和安全性。我们旨在评估不同剂量的替戈普拉唑-阿莫西林双重疗法根除幽门螺杆菌的有效性和安全性:这项前瞻性、随机、开放标签的多中心研究在中国福建的四个中心进行。H. 幽门螺杆菌感染患者按 1:1:1 的比例随机接受以下疗法之一:铋剂四联疗法(BQT,埃索美拉唑 20 毫克,每日两次;枸橼酸铋钾 240 毫克,每日两次;阿莫西林 1 克,每日两次;克拉霉素 500 毫克,每日两次)、替戈普拉赞-阿莫西林双联疗法(TA-qd,替戈普拉赞 50 毫克,每日一次;阿莫西林 1 克,每日三次;TA-bid,替戈普拉赞 50 毫克,每日两次;阿莫西林 1 克,每日三次),疗程 14 天。主要结果是不同TA组的根除率与BQT组相比无劣效。次要结果包括对不良反应和临床症状缓解情况的评估。此外,探索性结果侧重于肠道微生物群的变化和成本效益分析:结果:共有 321 名患者接受了治疗。在意向治疗分析(ITT)中,BQT 组、TA-qd 组和 TA-bid 组的根除率分别为 85.05%(91/107)、85.98%(92/107)和 85.98%(92/107)(BQT vs. TA-qd,95% CI -8.50% to 10.36%,非劣效性 p = 0.012;BQT vs. TA-bid,95% CI -8.50% to 10.36%,非劣效性 p = 0.012);在修正意向治疗分析(mITT)中,分别为 91.00%(91/100)、91.09%(92/101)和 92.93%(92/99)(BQT vs. TA-qd,95% CI -7.81% to 7.98%,非劣效性 p = 0.006;BQT vs. TA-bid,95% CI -5.62% to 9.48%,非劣效性 p 结论:与BQT相比,两种TA双重疗法的幽门螺杆菌根除率均大于90%,不良反应更少,临床症状缓解程度更高,对肠道微生物群的影响轻微且可逆。此外,TA与小剂量替戈普拉赞的双重疗法显示出更好的成本效益:试验注册:中国临床试验注册中心,注册号:ChiCTR2300071997。
{"title":"Tegoprazan-Amoxicillin Dual Therapy for Helicobacter pylori Eradication: A Prospective, Randomized, Multicenter Study in Fujian, China","authors":"Xueyan Lin,&nbsp;Huping Huang,&nbsp;Yijuan Liu,&nbsp;Yanling Zeng,&nbsp;Shiyun Lu,&nbsp;Xuefeng Xu,&nbsp;Yun Lin,&nbsp;Feng Qiu,&nbsp;Fangfang Cai,&nbsp;Jie Pan,&nbsp;Shaozhong Huang,&nbsp;Shaowei Lin,&nbsp;Aiping Lin,&nbsp;Zhihui Lin,&nbsp;Xueping Huang","doi":"10.1111/hel.13151","DOIUrl":"10.1111/hel.13151","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Few studies have investigated the efficacy and safety of tegoprazan-amoxicillin (TA) dual therapy for &lt;i&gt;Helicobacter pylori&lt;/i&gt; eradication. We aim to evaluate the effectiveness and safety of different dosages of TA dual therapy for &lt;i&gt;H. pylori&lt;/i&gt; eradication.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This prospective, randomized, open-label, multicenter study was conducted at four centers in Fujian, China. &lt;i&gt;H. pylori-&lt;/i&gt;infective patients were randomized 1:1:1 to receive one of the following treatments: bismuth quadruple therapy (BQT, esomeprazole 20 mg twice daily + potassium bismuth citrate 240 mg twice daily + amoxicillin 1 g twice daily + clarithromycin 500 mg twice daily), tegoprazan-amoxicillin dual therapies (TA-qd, tegoprazan 50 mg once daily + amoxicillin 1 g thrice daily; TA-bid, tegoprazan 50 mg twice daily + amoxicillin 1 g thrice daily) for 14 days. The primary outcome was noninferiority in eradication rates of the different TA groups compared to the BQT group. Secondary outcomes encompassed an assessment of adverse reactions and clinical symptom relief. Additionally, exploratory outcomes were focused on the shifts in gut microbiota and a cost-effectiveness analysis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 321 patients were enrolled. The eradication rates in the BQT group, TA-qd group, and TA-bid group were 85.05% (91/107), 85.98% (92/107), and 85.98% (92/107) in the intention-to-treat analysis (ITT) (BQT vs. TA-qd, 95% CI −8.50% to 10.36%, noninferiority &lt;i&gt;p&lt;/i&gt; = 0.012; BQT vs. TA-bid, 95% CI −8.50% to 10.36%, noninferiority &lt;i&gt;p&lt;/i&gt; = 0.012); 91.00% (91/100), 91.09% (92/101), and 92.93% (92/99) in the modified intention-to-treat analysis (mITT) (BQT vs. TA-qd, 95% CI −7.81% to 7.98%, noninferiority &lt;i&gt;p&lt;/i&gt; = 0.006; BQT vs. TA-bid, 95% CI −5.62% to 9.48%, noninferiority &lt;i&gt;p&lt;/i&gt; &lt; 0.001); 90.81% (89/98), 91.00% (91/100), and 93.81% (91/97) in the per-protocol analysis (PP) (BQT vs. TA-qd, 95% CI −7.83% to 8.19%, noninferiority &lt;i&gt;p&lt;/i&gt; = 0.006; BQT vs. TA-bid, 95% CI 4.46% to 10.46%, noninferiority &lt;i&gt;p&lt;/i&gt; &lt; 0.001). The incidence of adverse reactions in the TA-qd and TA-bid groups was significantly lower than in the BQT group (13.33%, 14.56%, and 27.18%, respectively; &lt;i&gt;p&lt;/i&gt; = 0.017). The complete remissions of clinical symptoms for BQT, TA-qd, and TA-bid were 36.89%, 65.71%, and 68.93%, respectively, had significant differences (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Two weeks of TA therapy altered gut microbiota diversity and composition, but that recovered 4 weeks after discontinuation. The cost-effectiveness ratios (CERs) for BQT, TA-qd, and TA-bid were 1.85 CNY, 2.08 CNY, and 3.69 CNY, respectively.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 ","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"29 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Efficacy and Safety of Potassium-Competitive Acid Blockers and Proton Pump Inhibitors for First-Line Helicobacter pylori Eradication Therapy: A Systematic Review and Network Meta-Analysis 钾竞争性酸阻滞剂和质子泵抑制剂在一线根除幽门螺旋杆菌疗法中的疗效和安全性比较:系统综述与网络元分析》。
IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-07 DOI: 10.1111/hel.13150
Mengling Ouyang, Shupeng Zou, Qian Cheng, Xuan Shi, Minghui Sun

Background

Given the increasing antibiotic resistance and the inadequate acid-suppressing effects of proton pump inhibitors (PPIs), it is crucial to continuously optimize existing Helicobacter pylori (H. pylori) treatment regimens. This study aimed to evaluate the clinical efficacy and safety of novel potassium-competitive acid blocker (P-CAB)-based eradication regimens compared with traditional PPI-based regimens for the initial treatment of H. pylori.

Materials and Methods

We conducted a systematic review and network meta-analysis, searching seven electronic databases for randomized controlled trials (RCTs) evaluating initial P-CAB-based H. pylori eradication therapy. The primary outcome was the H. pylori eradication rate. Secondary outcomes included adverse events and patient compliance. We synthesized the effect sizes of the trials using odds ratios (OR) and 95% confidence intervals (95% CI).

Results

A total of 54 RCTs involving 15,320 patients (74.9% male, mean age 30.2 years) were included in this study. In the intention-to-treat (ITT) analysis, VPZ-HD-dual, VPZ-triple, and VPZ-quadruple regimens demonstrated significantly higher eradication rates than PPI-triple, PPI-quadruple, and VPZ-dual regimens. Similar trends were observed in the per-protocol (PP) analysis. Subgroup analysis indicated that poor patient compliance significantly reduced eradication rates. Resistance to clarithromycin and metronidazole significantly weakened the eradication effects of PPI-triple, TPZ-triple, and VPZ-triple regimens. Additionally, the eradication rates for 7-day regimens were significantly lower than those for 14-day or 10-day regimens, but there was no significant difference between the eradication rates of 10-day and 14-day regimens. Notably, the risk of adverse events with VPZ-HD-dual was significantly lower than with VPZ-quadruple.

Conclusion

Vonoprazan combined with high-dose amoxicillin dual therapy not only provides satisfactory eradication rates but also exhibits lower adverse event rates and good patient compliance, indicating its potential as a promising regimen for further promotion.

背景:鉴于抗生素耐药性的增加和质子泵抑制剂(PPI)抑酸效果的不足,不断优化现有的幽门螺旋杆菌(H. pylori)治疗方案至关重要。本研究旨在评估基于钾竞争性酸阻滞剂(P-CAB)的新型根除方案与基于传统 PPI 的方案相比,在初始治疗幽门螺杆菌时的临床疗效和安全性:我们进行了一项系统综述和网络荟萃分析,在七个电子数据库中搜索了评估基于 P-CAB 的幽门螺杆菌初始根除疗法的随机对照试验 (RCT)。主要结果是幽门螺杆菌根除率。次要结果包括不良事件和患者依从性。我们使用几率比(OR)和 95% 置信区间(95% CI)对试验的效应大小进行了综合分析:本研究共纳入了 54 项 RCT,涉及 15,320 名患者(74.9% 为男性,平均年龄为 30.2 岁)。在意向治疗(ITT)分析中,VPZ-HD-二联疗法、VPZ-三联疗法和VPZ-四联疗法的根除率明显高于PPI-三联疗法、PPI-四联疗法和VPZ-二联疗法。在按方案(PP)分析中也观察到了类似的趋势。亚组分析表明,患者依从性差会显著降低根除率。对克拉霉素和甲硝唑的耐药性大大削弱了PPI-三联疗法、TPZ-三联疗法和VPZ-三联疗法的根除效果。此外,7 天治疗方案的根除率明显低于 14 天或 10 天治疗方案,但 10 天和 14 天治疗方案的根除率没有明显差异。值得注意的是,VPZ-HD-双联疗法的不良反应风险明显低于VPZ-四联疗法:结论:沃诺普拉赞联合大剂量阿莫西林双重疗法不仅能提供令人满意的根除率,而且不良反应发生率较低,患者依从性良好,这表明该疗法具有进一步推广的潜力。
{"title":"Comparative Efficacy and Safety of Potassium-Competitive Acid Blockers and Proton Pump Inhibitors for First-Line Helicobacter pylori Eradication Therapy: A Systematic Review and Network Meta-Analysis","authors":"Mengling Ouyang,&nbsp;Shupeng Zou,&nbsp;Qian Cheng,&nbsp;Xuan Shi,&nbsp;Minghui Sun","doi":"10.1111/hel.13150","DOIUrl":"10.1111/hel.13150","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Given the increasing antibiotic resistance and the inadequate acid-suppressing effects of proton pump inhibitors (PPIs), it is crucial to continuously optimize existing <i>Helicobacter pylori</i> (<i>H. pylori</i>) treatment regimens. This study aimed to evaluate the clinical efficacy and safety of novel potassium-competitive acid blocker (P-CAB)-based eradication regimens compared with traditional PPI-based regimens for the initial treatment of <i>H. pylori</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We conducted a systematic review and network meta-analysis, searching seven electronic databases for randomized controlled trials (RCTs) evaluating initial P-CAB-based <i>H. pylori</i> eradication therapy. The primary outcome was the <i>H. pylori</i> eradication rate. Secondary outcomes included adverse events and patient compliance. We synthesized the effect sizes of the trials using odds ratios (OR) and 95% confidence intervals (95% CI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 54 RCTs involving 15,320 patients (74.9% male, mean age 30.2 years) were included in this study. In the intention-to-treat (ITT) analysis, VPZ-HD-dual, VPZ-triple, and VPZ-quadruple regimens demonstrated significantly higher eradication rates than PPI-triple, PPI-quadruple, and VPZ-dual regimens. Similar trends were observed in the per-protocol (PP) analysis. Subgroup analysis indicated that poor patient compliance significantly reduced eradication rates. Resistance to clarithromycin and metronidazole significantly weakened the eradication effects of PPI-triple, TPZ-triple, and VPZ-triple regimens. Additionally, the eradication rates for 7-day regimens were significantly lower than those for 14-day or 10-day regimens, but there was no significant difference between the eradication rates of 10-day and 14-day regimens. Notably, the risk of adverse events with VPZ-HD-dual was significantly lower than with VPZ-quadruple.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Vonoprazan combined with high-dose amoxicillin dual therapy not only provides satisfactory eradication rates but also exhibits lower adverse event rates and good patient compliance, indicating its potential as a promising regimen for further promotion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"29 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Bismuth Quadruple Therapy in the Treatment of Helicobacter pylori-Infected Peptic Ulcer Children in Vietnam 四联铋疗法治疗越南幽门螺旋杆菌感染的消化性溃疡患儿的疗效。
IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-05 DOI: 10.1111/hel.13149
Thi Minh Phuong Do, Thi Huyen Trang Tran, Van Tinh Nguyen, Thi Phuong Mai Chu, Loi Nguyen, Kim Thanh Nguyen, Thi Bich Ngoc Hoang, Anh Le Huu Phuong, Yoshio Yamaoka, Linus Olson, Thi Viet Ha Nguyen

Background

The continuous increase in drug-resistant strains, the lack of novel antibiotics, and the fewer options available to combat antibiotic-resistant infections in pediatrics pose significant challenges to the eradication of Helicobacter pylori (H. pylori) in children. This study evaluated the efficacy of first-line therapy with bismuth quadruple therapy in H. pylori-positive pediatric patients with peptic ulcers.

Materials and Methods

136 patients (aged between 8 and 17 years) diagnosed with active peptic ulcers with H. pylori infection were enrolled in this study. Patients with H. pylori strain sensitive to tetracycline and metronidazole were assigned to bismuth quadruple therapy, including a proton pump inhibitor (PPI), bismuth, tetracycline, and metronidazole. Antibiotic resistance of H. pylori was analyzed by the Epsilometer test. Treatment efficacy was evaluated at 12 weeks based on H. pylori eradication and peptic ulcer healing rates. H. pylori infection status was evaluated by a 13C-urea breath test.

Results

Most isolates showed extremely high rates of resistance to commonly prescribed antibiotics used for children, including clarithromycin (97.0%) and amoxicillin (84.6%), while the low rate of resistance to levofloxacin (16.2%). The overall success rate of eradication therapy in the intention-to-treat and the per-protocol group were 86.0% and 89.3%, respectively. Peptic ulcer healing rates for total patients at 6 weeks and 12 weeks were 75.0% and 97.7%, respectively. There were no entail unpleasant adverse events, and peptic ulcer symptoms decreased steadily over time in all cases.

Conclusions

The bismuth quadruple therapy with a 2-week PPI pretreatment and followed by prolonged PPI was highly successful in eradicating H. pylori infection and healing ulcers in pediatric patients with active peptic ulcer. This might be preferable as a first-line empiric treatment regimen for H. pylori-positive pediatric patients with peptic ulcers, especially in populations with high rates of resistance to amoxicillin and clarithromycin.

背景:耐药菌株的不断增加、新型抗生素的缺乏以及儿科抗生素耐药感染可选方案的减少,给根除儿童幽门螺杆菌(H. pylori)带来了巨大挑战。本研究评估了幽门螺杆菌阳性的消化性溃疡儿科患者接受四联铋剂一线治疗的疗效。材料和方法:本研究共招募了136名确诊为幽门螺杆菌感染的活动性消化性溃疡患者(年龄在8至17岁之间)。幽门螺杆菌菌株对四环素和甲硝唑敏感的患者被分配接受铋剂四联疗法,包括质子泵抑制剂(PPI)、铋剂、四环素和甲硝唑。幽门螺杆菌的抗生素耐药性通过益普索试验进行分析。根据幽门螺杆菌根除率和消化性溃疡愈合率评估 12 周后的疗效。幽门螺杆菌感染状况通过 13C- 尿素呼气试验进行评估:大多数分离菌株对儿童常用抗生素的耐药率极高,包括克拉霉素(97.0%)和阿莫西林(84.6%),而对左氧氟沙星的耐药率较低(16.2%)。意向治疗组和按方案治疗组的根除疗法总体成功率分别为86.0%和89.3%。6周和12周时,所有患者的消化性溃疡愈合率分别为75.0%和97.7%。所有病例均未出现令人不悦的不良反应,消化性溃疡症状随时间推移稳步减轻:结论:铋剂四联疗法加上为期两周的 PPI 预处理和随后的长期 PPI,在根除幽门螺杆菌感染和治愈活动性消化性溃疡儿童患者的溃疡方面非常成功。对于幽门螺杆菌阳性的消化性溃疡儿科患者,尤其是对阿莫西林和克拉霉素耐药率较高的人群,这可能更适合作为一线经验性治疗方案。
{"title":"Efficacy of Bismuth Quadruple Therapy in the Treatment of Helicobacter pylori-Infected Peptic Ulcer Children in Vietnam","authors":"Thi Minh Phuong Do,&nbsp;Thi Huyen Trang Tran,&nbsp;Van Tinh Nguyen,&nbsp;Thi Phuong Mai Chu,&nbsp;Loi Nguyen,&nbsp;Kim Thanh Nguyen,&nbsp;Thi Bich Ngoc Hoang,&nbsp;Anh Le Huu Phuong,&nbsp;Yoshio Yamaoka,&nbsp;Linus Olson,&nbsp;Thi Viet Ha Nguyen","doi":"10.1111/hel.13149","DOIUrl":"10.1111/hel.13149","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The continuous increase in drug-resistant strains, the lack of novel antibiotics, and the fewer options available to combat antibiotic-resistant infections in pediatrics pose significant challenges to the eradication of <i>Helicobacter pylori (H. pylori)</i> in children. This study evaluated the efficacy of first-line therapy with bismuth quadruple therapy in <i>H. pylori</i>-positive pediatric patients with peptic ulcers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>136 patients (aged between 8 and 17 years) diagnosed with active peptic ulcers with <i>H. pylori</i> infection were enrolled in this study. Patients with <i>H. pylori</i> strain sensitive to tetracycline and metronidazole were assigned to bismuth quadruple therapy, including a proton pump inhibitor (PPI), bismuth, tetracycline, and metronidazole. Antibiotic resistance of <i>H. pylori</i> was analyzed by the Epsilometer test. Treatment efficacy was evaluated at 12 weeks based on <i>H. pylori</i> eradication and peptic ulcer healing rates. <i>H. pylori</i> infection status was evaluated by a <sup>13</sup>C-urea breath test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Most isolates showed extremely high rates of resistance to commonly prescribed antibiotics used for children, including clarithromycin (97.0%) and amoxicillin (84.6%), while the low rate of resistance to levofloxacin (16.2%). The overall success rate of eradication therapy in the intention-to-treat and the per-protocol group were 86.0% and 89.3%, respectively. Peptic ulcer healing rates for total patients at 6 weeks and 12 weeks were 75.0% and 97.7%, respectively. There were no entail unpleasant adverse events, and peptic ulcer symptoms decreased steadily over time in all cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The bismuth quadruple therapy with a 2-week PPI pretreatment and followed by prolonged PPI was highly successful in eradicating <i>H. pylori</i> infection and healing ulcers in pediatric patients with active peptic ulcer. This might be preferable as a first-line empiric treatment regimen for <i>H. pylori</i>-positive pediatric patients with peptic ulcers, especially in populations with high rates of resistance to amoxicillin and clarithromycin.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"29 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Map-Like Redness Development After Eradication Therapy for Helicobacter pylori Infection: Prospective Multicenter Observational Study 幽门螺杆菌感染根除疗法后出现的地图样红斑:前瞻性多中心观察研究。
IF 4.3 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-03 DOI: 10.1111/hel.13146
Sho Matsumoto, Mitsushige Sugimoto, Tomohiro Terai, Yasuhiko Maruyama, Shu Sahara, Shigeru Kanaoka, Yashiro Yoshizawa, Shuhei Unno, Masaki Murata, Takahiro Uotani, Tomohiro Sugiyama, Shigemi Nakajima, Kiyoyuki Hayafuji, Ken Haruma, Tomoari Kamada, Masakatsu Fukuzawa, Takashi Kawai, Takao Itoi

Background

Map-like redness, pathological intestinal metaplasia, is observed in one-fourth to one-third of patients 1 year after Helicobacter pylori eradication therapy, mainly in the corpus, and is a newly identified endoscopic risk factor for gastric cancer development after eradication. However, it is unclear whether intestinal metaplasia is present before eradication at the site where the map-like redness appears. We aimed to identify endoscopic findings that predict the occurrence of map-like redness before H. pylori eradication.

Materials and Methods

As a prospective multicenter trial, the characteristics of patients in whom map-like redness developed after eradication, and the association between the endoscopic severity of gastritis and the development of map-like redness in patients who underwent endoscopy before and 1-year after eradication were investigated.

Results

The rate of map-like redness in all 93 patients 1-year postsuccessful eradication was 30.1% (95% confidence interval [CI]: 21.0–40.5). All patients with map-like redness were endoscopically observed to have intestinal metaplasia before eradication, in the site that subsequently developed map-like redness. Patients who developed map-like redness were older, had more severe intestinal metaplasia and nodularity and a higher total score on the Kyoto Classification of Gastritis both before and after eradication than patients who did not. On multivariate analysis, map-like redness was found to be associated with posttreatment intestinal metaplasia (odds ratio: 8.144; 95% CI: 2.811–23.592).

Conclusions

In all patients who developed map-like redness after eradication, endoscopic intestinal metaplasia was observed at the site developed map-like redness before eradication therapy. Map-like redness was especially observed in patients with more severe intestinal metaplasia at 1-year after eradication. Such patients require increased attention at surveillance endoscopy, owing to generally having a higher risk of gastric cancer development.

Trial Registration

University Hospital Medical Information Network: UMIN000044707

背景:幽门螺杆菌根除治疗 1 年后,四分之一到三分之一的患者会出现地图样发红,即病理性肠化生,主要发生在胃体,这是新发现的根除后胃癌发生的内镜风险因素。然而,目前还不清楚在根除前出现地图样发红的部位是否存在肠化生。我们的目的是找出能预测幽门螺杆菌根除前出现地图样发红的内镜检查结果:作为一项前瞻性多中心试验,我们调查了根除幽门螺杆菌后出现地图样发红的患者特征,以及根除幽门螺杆菌前和根除幽门螺杆菌1年后接受内镜检查的患者的内镜下胃炎严重程度与出现地图样发红之间的关联:结果:所有93名患者在成功根除后1年出现地图样发红的比例为30.1%(95%置信区间[CI]:21.0-40.5)。所有出现地图样发红的患者均在根除前经内镜观察发现有肠化生,并在随后出现地图样发红的部位。与未出现地图样发红的患者相比,出现地图样发红的患者年龄更大,肠化生和结节更严重,根除前后的京都胃炎分类总分更高。多变量分析发现,地图样发红与治疗后肠化生有关(几率比:8.144;95% CI:2.811-23.592):结论:在所有根除治疗后出现地图样发红的患者中,根除治疗前出现地图样发红的部位均可观察到内镜下肠化生。尤其是在根除治疗后 1 年,在肠化生更为严重的患者中观察到了地图样发红。由于这类患者发生胃癌的风险通常较高,因此需要在监测内镜检查时给予更多关注:试验注册:大学医院医学信息网:UMIN000044707.
{"title":"Map-Like Redness Development After Eradication Therapy for Helicobacter pylori Infection: Prospective Multicenter Observational Study","authors":"Sho Matsumoto,&nbsp;Mitsushige Sugimoto,&nbsp;Tomohiro Terai,&nbsp;Yasuhiko Maruyama,&nbsp;Shu Sahara,&nbsp;Shigeru Kanaoka,&nbsp;Yashiro Yoshizawa,&nbsp;Shuhei Unno,&nbsp;Masaki Murata,&nbsp;Takahiro Uotani,&nbsp;Tomohiro Sugiyama,&nbsp;Shigemi Nakajima,&nbsp;Kiyoyuki Hayafuji,&nbsp;Ken Haruma,&nbsp;Tomoari Kamada,&nbsp;Masakatsu Fukuzawa,&nbsp;Takashi Kawai,&nbsp;Takao Itoi","doi":"10.1111/hel.13146","DOIUrl":"10.1111/hel.13146","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Map-like redness, pathological intestinal metaplasia, is observed in one-fourth to one-third of patients 1 year after <i>Helicobacter pylori</i> eradication therapy, mainly in the corpus, and is a newly identified endoscopic risk factor for gastric cancer development after eradication. However, it is unclear whether intestinal metaplasia is present before eradication at the site where the map-like redness appears. We aimed to identify endoscopic findings that predict the occurrence of map-like redness before <i>H. pylori</i> eradication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>As a prospective multicenter trial, the characteristics of patients in whom map-like redness developed after eradication, and the association between the endoscopic severity of gastritis and the development of map-like redness in patients who underwent endoscopy before and 1-year after eradication were investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The rate of map-like redness in all 93 patients 1-year postsuccessful eradication was 30.1% (95% confidence interval [CI]: 21.0–40.5). All patients with map-like redness were endoscopically observed to have intestinal metaplasia before eradication, in the site that subsequently developed map-like redness. Patients who developed map-like redness were older, had more severe intestinal metaplasia and nodularity and a higher total score on the Kyoto Classification of Gastritis both before and after eradication than patients who did not. On multivariate analysis, map-like redness was found to be associated with posttreatment intestinal metaplasia (odds ratio: 8.144; 95% CI: 2.811–23.592).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In all patients who developed map-like redness after eradication, endoscopic intestinal metaplasia was observed at the site developed map-like redness before eradication therapy. Map-like redness was especially observed in patients with more severe intestinal metaplasia at 1-year after eradication. Such patients require increased attention at surveillance endoscopy, owing to generally having a higher risk of gastric cancer development.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>University Hospital Medical Information Network: UMIN000044707</p>\u0000 </section>\u0000 </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"29 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/hel.13146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Helicobacter
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1