{"title":"Revealing the Therapeutic Potential: Investigating the Impact of a Novel Witch Hazel Formula on Anti-Inflammation and Antioxidation.","authors":"Xue Liu, Tamer-Whittle Hage, Li-Chi Chen, Eddy Hsi Chun Wang, I-Chien Liao, Jodi Goldberg, Sabina Gosto, Paula Cziryak, Maryanne Senna, Ying Chen, Qian Zheng","doi":"10.1111/jocd.16662","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Skin barrier health is crucial for preventive and corrective skincare across all skin types. Witch hazel (Hamamelis virginiana) extracts show potential in addressing skin issues, but their efficacy in treating chronic inflammation, improving skin barrier function, and combating UV-induced oxidation requires further investigation.</p><p><strong>Aims: </strong>To evaluate the efficacy of a novel formula containing witch hazel extracts in treating chronic inflammation, improving skin barrier function, and combating UV-induced oxidation.</p><p><strong>Methods: </strong>We employed a novel ex vivo chronic inflammation model to assess anti-inflammatory effects, measuring key pro-inflammatory cytokines. Barrier function markers, such as loricrin and transglutaminase-1, were analyzed. An ex vivo model with UV-induced Reactive Oxygen Species (ROS) elevation was used to evaluate antioxidant properties, measuring specific ROS markers like 4-Hydroxynonenal and carbonylated protein.</p><p><strong>Results: </strong>The novel witch hazel formula significantly reduced pro-inflammatory cytokines in both 2D and ex vivo models, including IL-6 and IL-8, demonstrating potent anti-inflammatory effects. Barrier function markers showed notable improvements compared to the inflamed condition. In the UV-induced ROS model, the formula remarkably decreased ROS levels, specifically 4-Hydroxynonenal and carbonylated protein, indicating strong antioxidant properties.</p><p><strong>Conclusions: </strong>Our findings demonstrate that the novel witch hazel formula exhibits potent anti-inflammatory and antioxidant properties while enhancing skin barrier function. This natural, well-tolerated ingredient offers a promising treatment option for improving overall skin health, presenting new opportunities in skincare formulation and treatment strategies.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cosmetic Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/jocd.16662","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Skin barrier health is crucial for preventive and corrective skincare across all skin types. Witch hazel (Hamamelis virginiana) extracts show potential in addressing skin issues, but their efficacy in treating chronic inflammation, improving skin barrier function, and combating UV-induced oxidation requires further investigation.
Aims: To evaluate the efficacy of a novel formula containing witch hazel extracts in treating chronic inflammation, improving skin barrier function, and combating UV-induced oxidation.
Methods: We employed a novel ex vivo chronic inflammation model to assess anti-inflammatory effects, measuring key pro-inflammatory cytokines. Barrier function markers, such as loricrin and transglutaminase-1, were analyzed. An ex vivo model with UV-induced Reactive Oxygen Species (ROS) elevation was used to evaluate antioxidant properties, measuring specific ROS markers like 4-Hydroxynonenal and carbonylated protein.
Results: The novel witch hazel formula significantly reduced pro-inflammatory cytokines in both 2D and ex vivo models, including IL-6 and IL-8, demonstrating potent anti-inflammatory effects. Barrier function markers showed notable improvements compared to the inflamed condition. In the UV-induced ROS model, the formula remarkably decreased ROS levels, specifically 4-Hydroxynonenal and carbonylated protein, indicating strong antioxidant properties.
Conclusions: Our findings demonstrate that the novel witch hazel formula exhibits potent anti-inflammatory and antioxidant properties while enhancing skin barrier function. This natural, well-tolerated ingredient offers a promising treatment option for improving overall skin health, presenting new opportunities in skincare formulation and treatment strategies.
期刊介绍：
The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques.
The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.
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