68Ga-FAPI and 18F-NaF PET/CT in psoriatic arthritis: a comparative study.

IF 4.7 2区医学 Q1 RHEUMATOLOGY Rheumatology Pub Date : 2024-11-22 DOI:10.1093/rheumatology/keae577

Fan Yang, Chaofan Lu, Qingqing Pan, Rui Zhang, Meng Yang, Qian Wang, Mengtao Li, Xiaofeng Zeng, Yaping Luo, Xiaomei Leng

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Abstract

Objectives: As fibroblast-like synoviocyte activation and bone formation are associated with psoriatic arthritis (PsA), positron emission tomography (PET) using the tracers of 68Ga-fibroblast activation protein inhibitor (FAPI) and 18F-sodium fluoride (NaF) may sensitively detect the disease. In this prospective study, we aimed to evaluate the performance of 68Ga-FAPI PET/CT in PsA and to compare it with 18F-NaF PET/CT.

Methods: Sixteen participants (female 7/16, age 42.31 ± 10.66 years) with PsA were prospectively enrolled and underwent dual-tracer PET/CT, clinical assessment and ultrasonography. PET/CT images were scored for PET-positive lesions at the peripheral joints, entheses, and axial joints.

Results: The positivity rate of 68Ga-FAPI in peripheral joints is higher than that in entheses and axial joints (21.84% vs 12.15% vs 0%), whereas high positivity rates of 18F-NaF in peripheral joints, entheses, and axial joints were observed (85.23%, 78.13%, and 75%, respectively). The disease activity score 28 was higher in the PET-positive than in the PET-negative group with 68Ga-FAPI (5.25 ± 1.84 vs 2.55 ± 0.94, p= 0.037), but not with 18F-NaF. Besides, the PET joint count at 68Ga-FAPI PET/CT was positively correlated with the TJC (r = 0.604, p= 0.017), SJC (r = 0.773, p= 0.001), DAS28-CRP (r = 0.556, p= 0.032), PASDAS (r = 0.540, p= 0.038) and PsASon13 (r = 0.701, p= 0.005), while no correlation was observed in 18F-NaF PET/CT.

Conclusion: The positivity rates of 68Ga-FAPI- and 18F-NaF PET/CT were different in patients with PsA in peripheral joints, entheses, and axial joints. The extent of joint involvement at 68Ga-FAPI PET/CT correlated with clinical and ultrasound variables as well as disease activity.

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银屑病关节炎中的 68Ga-FAPI 和 18F-NaF PET/CT：一项比较研究。

目的：由于成纤维细胞样滑膜细胞活化和骨形成与银屑病关节炎（PsA）有关，使用68Ga-成纤维细胞活化蛋白抑制剂（FAPI）和18F-氟化钠（NaF）示踪剂的正电子发射断层扫描（PET）可灵敏地检测该疾病。在这项前瞻性研究中，我们旨在评估 68Ga-FAPI PET/CT 在 PsA 中的表现，并将其与 18F-NaF PET/CT 进行比较：16名PsA患者（女性7/16，年龄42.31 ± 10.66岁）接受了双示踪剂PET/CT、临床评估和超声波检查。对 PET/CT 图像中外周关节、内膜和轴关节的 PET 阳性病变进行评分：68Ga-FAPI在外周关节的阳性率（21.84% vs 12.15% vs 0%）高于内关节和轴关节，而18F-NaF在外周关节、内关节和轴关节的阳性率较高（分别为85.23%、78.13%和75%）。68Ga-FAPI的PET阳性组疾病活动度评分28高于PET阴性组（5.25 ± 1.84 vs 2.55 ± 0.94，p= 0.037），而18F-NaF则不然。此外，68Ga-FAPI PET/CT 的 PET 关节计数与 TJC（r = 0.604，p= 0.017）、SJC（r = 0.773，p= 0.001）、DAS28-CRP（r = 0.556，p= 0.032）、PASDAS（r= 0.540，p= 0.038）和PsASon13（r= 0.701，p= 0.005），而在18F-NaF PET/CT中未观察到相关性：结论：在PsA患者中，68Ga-FAPI-和18F-NaF PET/CT在外周关节、内侧关节和轴关节的阳性率不同。68Ga-FAPI PET/CT 的关节受累程度与临床和超声变量以及疾病活动性相关。

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来源期刊

Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

7.30%

发文量

1091

审稿时长

2 months

期刊介绍： Rheumatology strives to support research and discovery by publishing the highest quality original scientific papers with a focus on basic, clinical and translational research. The journal’s subject areas cover a wide range of paediatric and adult rheumatological conditions from an international perspective. It is an official journal of the British Society for Rheumatology, published by Oxford University Press. Rheumatology publishes original articles, reviews, editorials, guidelines, concise reports, meta-analyses, original case reports, clinical vignettes, letters and matters arising from published material. The journal takes pride in serving the global rheumatology community, with a focus on high societal impact in the form of podcasts, videos and extended social media presence, and utilizing metrics such as Altmetric. Keep up to date by following the journal on Twitter @RheumJnl.