Post-procedure pain in preterm neonates undergoing retinopathy of prematurity (ROP) screening: a prospective cohort study.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Perinatology Pub Date : 2024-11-21 DOI:10.1038/s41372-024-02107-x

Raman Singla, Ankit Verma, Vivek Kumar, Purna Chandra, Parijat Chandra, Anu Thukral, M Jeeva Sankar, Ramesh Agarwal, Ashok Kumar Deorari

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Abstract

Objective: To evaluate the pain intensity in preterm infants during 48 h post retinopathy of prematurity (ROP) screening by binocular fundoscopy.

Design: Prospective cohort study.

Settings: Level-III-NICU in India.

Participants: 83 Neonates undergoing first ROP screening.

Main outcome measures: Pain assessment using the premature infant pain profile-revised (PIPP-R) score at baseline and 5 min, 30 min, 6 h, 24 h, and 48 h post-procedure.

Results: The mean gestation and birth weight was 29.8 (2.3) weeks and 1256 (344)g respectively. The median (IQR) PIPP-R score at baseline was 0 which significantly increased to 10.5 (8,12.5) 5 min (immediately) after the procedure. At 30 min and 6 h, scores were 7 (5,8) and 4.5 (3,5.5) respectively. After 24 h and 48 h, it decreased to 3 (0,5) and 0 (0,4.5) respectively. Nearly 59% (95%CI:40%-83%) of neonates had severe pain (PIPP-R score > 12) immediately after procedure.

Conclusion: A majority of neonates experience severe pain immediately after ROP screening, and mild-moderate pain continues for 6 h. Hence, an additional pharmacological agent should be considered for reducing neonatal pain.

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接受早产儿视网膜病变（ROP）筛查的早产儿术后疼痛：一项前瞻性队列研究。

目的：评估早产儿在接受双目眼底镜检查后 48 小时内的疼痛强度：评估早产儿在双目眼底镜检查早产儿视网膜病变（ROP）48小时后的疼痛强度：设计：前瞻性队列研究：参与者：83 名首次接受早产儿视网膜病变筛查的新生儿：主要结果测量：在基线和术后 5 分钟、30 分钟、6 小时、24 小时和 48 小时使用早产儿疼痛档案修订版（PIPP-R）评分进行疼痛评估：平均孕期和出生体重分别为 29.8 (2.3) 周和 1256 (344) 克。基线时的 PIPP-R 评分中位数（IQR）为 0，在手术后 5 分钟（即刻）明显升至 10.5（8,12.5）分。30 分钟和 6 小时后，得分分别为 7（5,8）和 4.5（3,5.5）。24 小时和 48 小时后，得分分别降至 3 (0,5) 和 0 (0,4.5)。近59%（95%CI:40%-83%）的新生儿在手术后立即出现剧烈疼痛（PIPP-R 评分 > 12）：结论：大多数新生儿在接受 ROP 筛查后会立即感到剧烈疼痛，轻度至中度疼痛会持续 6 小时。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.