Unlocking the potential of Cupriavidus necator H16 as a platform for bioproducts production from carbon dioxide.

IF 4 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY World journal of microbiology & biotechnology Pub Date : 2024-11-22 DOI:10.1007/s11274-024-04200-x

Yuheng Wang, Lin Cui, Lijuan Ding, Xiaoyun Su, Huiying Luo, Huoqing Huang, Yuan Wang, Bin Yao, Jie Zhang, Xiaolu Wang

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Abstract

The rapid global increase in fossil fuel and energy consumption has resulted in the accumulation of greenhouse gases, especially carbon dioxide (CO₂), thus contributing to climate change. Therefore, transforming CO₂ into valuable products could yield beneficial outcomes. In this review, the capabilities of Cupriavidus necator H16, a light-independent chemoautotrophic bacterium, as a host platform for the transformation of CO₂ into diverse products are explored. We begin by examining the progress in synthetic biology toolkits, gas fermentation technologies, and engineering approaches, considering the chemoautotrophic metabolic traits of C. necator to enhance the capacity of the strain for CO₂ fixation. Additionally, recent research focused on the metabolic engineering of C. necator H16 for the conversion of CO₂ into biodegradable plastics, biofuels, bioactive compounds, and single-cell proteins was reviewed. Finally, we address the limitations affecting the advancement and utilization of C. necator H16 strain, such as inefficiencies and the range of product types, and offer several recommendations for enhancement. This review acts as a resource for the development of C. necator H16 cell factories and the industrial manufacture of products derived from CO₂.

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挖掘坏死葡萄球菌 H16 的潜力，将其作为利用二氧化碳生产生物产品的平台。

全球化石燃料和能源消耗的快速增长导致温室气体，特别是二氧化碳（CO2）的积累，从而加剧了气候变化。因此，将二氧化碳转化为有价值的产品可以产生有益的结果。在这篇综述中，我们探讨了不依赖光的化能自养细菌（Cupriavidus necator H16）作为宿主平台将二氧化碳转化为多种产品的能力。我们首先考察了合成生物学工具包、气体发酵技术和工程方法方面的进展，考虑了 C. necator 的化学自养代谢特征，以提高菌株固定二氧化碳的能力。此外，我们还综述了最近关于将 C. necator H16 的代谢工程转化为可生物降解塑料、生物燃料、生物活性化合物和单细胞蛋白质的研究。最后，我们讨论了影响 C. necator H16 菌株进步和利用的限制因素，如效率低下和产品类型范围，并提出了一些改进建议。这篇综述为开发 C. necator H16 细胞工厂和二氧化碳衍生产品的工业生产提供了资源。

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来源期刊

World journal of microbiology & biotechnology 工程技术-生物工程与应用微生物

CiteScore

6.30

自引率

2.40%

发文量

257

审稿时长

2.5 months

期刊介绍： World Journal of Microbiology and Biotechnology publishes research papers and review articles on all aspects of Microbiology and Microbial Biotechnology. Since its foundation, the Journal has provided a forum for research work directed toward finding microbiological and biotechnological solutions to global problems. As many of these problems, including crop productivity, public health and waste management, have major impacts in the developing world, the Journal especially reports on advances for and from developing regions. Some topics are not within the scope of the Journal. Please do not submit your manuscript if it falls into one of the following categories: · Virology · Simple isolation of microbes from local sources · Simple descriptions of an environment or reports on a procedure · Veterinary, agricultural and clinical topics in which the main focus is not on a microorganism · Data reporting on host response to microbes · Optimization of a procedure · Description of the biological effects of not fully identified compounds or undefined extracts of natural origin · Data on not fully purified enzymes or procedures in which they are applied All articles published in the Journal are independently refereed.