Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan.

IF 6.2 2区医学 Q1 ALLERGY Allergology International Pub Date : 2024-08-19 DOI:10.1016/j.alit.2024.06.002

Tsukasa Okamoto, Mariko Hanafusa, Taketomo Abe, Takashi Shimamura, Masaru Ito, Yoko Wakai, Torahiko Jinta, Katsuyuki Higa, Yasuhiro Kondoh, Yasumi Okouchi, Ryo Okuda, Masashi Bando, Takafumi Suda, Hiromi Tomioka, Takeo Fujiwara, Masato Takase, Shigemi Yoshihara, Hiroshi Odajima, Yasunari Miyazaki

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Abstract

Background: The latest guidelines on hypersensitivity pneumonitis (HP) categorise the disease as either fibrotic or non-fibrotic because of the greater clinical utility of this stratification. However, the prevalence and incidence of fibrotic and non-fibrotic HP are unknown. This study assessed the exact prevalence and incidence of fibrotic and non-fibrotic HP in Japan in 2021.

Methods: For adults, the study hospitals were selected by stratified random sampling according to numbers of beds. The sampling rate was set at about 20%. The questionnaire survey was submitted to the target hospitals. For pediatric cases, a survey was distributed to all members of the Japanese Society of Pediatric Pulmonology and Japanese Society of Pediatric Allergy and Clinical Immunology.

Results: Regarding adult cases, in total, 575 facilities responded to the survey, resulting in a response rate of 36.4%. The estimated prevalence and incidence of fibrotic HP were 6.3 and 2.5 per 100,000 population, respectively, versus 3.6 and 2.0 per 100,000 population, respectively, for non-fibrotic HP. Both fibrotic and non-fibrotic HP were more prevalent in southern Japan (Kyushu) and less prevalent in northern Japan (Hokkaido). The incidence of non-fibrotic HP was significantly lower in December than in the other months (relative risk ratio = 0.36, p < 0.001). Three cases of fibrotic HP and five cases of non-fibrotic HP were identified in children.

Conclusions: This study determined the prevalence and incidence of fibrotic and non-fibrotic HP in Japan for the first time.

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日本超敏性肺炎的估计流行率和发病率。

背景：最新的超敏性肺炎（HP）指南将该病分为纤维化和非纤维化两类，因为这种分层方法的临床实用性更高。然而，纤维化和非纤维化超敏性肺炎的患病率和发病率尚不清楚。本研究评估了 2021 年日本纤维化和非纤维化 HP 的确切患病率和发病率：对于成人，研究医院根据床位数进行分层随机抽样。抽样率设定为约 20%。向目标医院提交问卷调查。对于儿科病例，向日本儿科肺病学会和日本儿科过敏与临床免疫学会的所有会员发放了调查问卷：在成人病例方面，共有 575 家医院对调查做出了回复，回复率为 36.4%。据估计，纤维化型高血压的患病率和发病率分别为每 10 万人 6.3 例和 2.5 例，而非纤维化型高血压的患病率和发病率分别为每 10 万人 3.6 例和 2.0 例。纤维化和非纤维化 HP 在日本南部（九州）的发病率较高，而在日本北部（北海道）的发病率较低。非纤维化 HP 的发病率在 12 月份明显低于其他月份（相对风险比 = 0.36，p 结论：非纤维化 HP 的发病率在 12 月份明显低于其他月份（相对风险比 = 0.36，p）：本研究首次确定了纤维化和非纤维化 HP 在日本的流行率和发病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergology International ALLERGY-IMMUNOLOGY

CiteScore

12.60

自引率

5.90%

发文量

审稿时长

29 weeks

期刊介绍： Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense. The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.