Chronic psychological stress induces testicular oxidative stress affecting reproductive behavior in rats

IF 2.5 3区生物学 Q3 REPRODUCTIVE BIOLOGY Reproductive biology Pub Date : 2024-11-20 DOI:10.1016/j.repbio.2024.100934

Tianfeng Yang , Xinye Liu , Chunyan Kang , Gonglin Hou , Yunyun Shen , Zheqi Liu

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Abstract

The inhibitory effect of chronic psychological stress on reproductive behavior is widely recognized since long. However, the biological mechanisms underlying these effects, especially the cellular biology of the testicular cells, have not been fully investigated. This study aimed to investigate the effects of chronic psychological stress on rat reproductive behavior and its correlation with testicular cell damage and oxidative stress. The results showed that chronic psychological stress led to a decline in the preference scores of male rats for female rats and caused damage to the testicular tissue structure. Subcellular structures were particularly affected in the chronic psychological stress rats. Furthermore, the levels of MDA, NO, and NOS in testicular cells substantially increased under chronic psychological stress conditions. In conclusion, male reproductive behavioral disorders induced by chronic psychological stress are potentially linked to oxidative damage in testicular tissue.

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慢性心理压力会诱发影响大鼠生殖行为的睾丸氧化应激。

长期心理压力对生殖行为的抑制作用早已得到广泛认可。然而，这些影响的生物学机制，尤其是睾丸细胞的细胞生物学机制尚未得到充分研究。本研究旨在探讨慢性心理应激对大鼠生殖行为的影响及其与睾丸细胞损伤和氧化应激的相关性。结果显示，慢性心理应激导致雄性大鼠对雌性大鼠的偏好评分下降，并对睾丸组织结构造成损伤。慢性心理应激大鼠的亚细胞结构尤其受到影响。此外，在慢性心理应激条件下，睾丸细胞中的 MDA、NO 和 NOS 水平大幅升高。总之，慢性心理应激诱发的男性生殖行为障碍可能与睾丸组织的氧化损伤有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive biology 生物-生殖生物学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

29 days

期刊介绍： An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn, Poland. Reproductive Biology is an international, peer-reviewed journal covering all aspects of reproduction in vertebrates. The journal invites original research papers, short communications, review articles and commentaries dealing with reproductive physiology, endocrinology, immunology, molecular and cellular biology, receptor studies, animal breeding as well as andrology, embryology, infertility, assisted reproduction and contraception. Papers from both basic and clinical research will be considered.