Fe-coordinated carbon dots with single atom nanozyme catalytic activity for synergistic catalytic/chemo-therapy in breast cancer

IF 7.7 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Macromolecules Pub Date : 2024-12-01 DOI:10.1016/j.ijbiomac.2024.137776

Mengke Lu , Jianxia Ding , Yupeng Zhang , Xuan Gu , Jiaying Liu , Qinxin Wang , Xiaonan Qiu , Huijun Yu , Fengyi Du , Wei Zhang

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Abstract

Single atom nanozyme (SAzyme) based on carbon dots (CDs) has showed great potential in oncotherapy via ultrasmall size-reinforced atomically dispersed catalytic sites. However, its curative effect is still unsatisfactory due to complex tumor microenvironment and intrinsic resistance. Herein, a coordinated carbon dots (CCDs)-integrated ZIF-8 nanoassembly (Ru/CCDs-PTX@ZIF) was constructed by loading paclitaxel and coating with rutin for synergistic catalytic/chemotherapy. Benefiting from inherited metal-polyphenol coordination, the CCDs exhibited superior peroxidase-like (POD) activity and served as a SAzyme to produce large amounts of hydroxyl radical, resulting in radical-dependent cell cycle arrest. With the assistance of GLUT receptor-mediated endocytosis, the Ru/CCDs-PTX@ZIF triggered the tumor-targeted killing and migration inhibition to suppress tumor progression. This study highlights a promising avenue to broaden the design and applications of CDs-based SAzyme in tumor treatment.

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具有单原子纳米酶催化活性的铁配位碳点用于乳腺癌的协同催化/化疗。

基于碳点（CD）的单原子纳米酶（SAzyme）通过超小尺寸强化原子分散的催化位点，在肿瘤治疗中显示出巨大的潜力。然而，由于复杂的肿瘤微环境和内在抗药性，其治疗效果仍不尽如人意。本文通过负载紫杉醇和涂覆芦丁，构建了配位碳点（CCDs）-集成 ZIF-8 纳米组件（Ru/CCDs-PTX@ZIF），以实现协同催化/化疗。由于继承了金属-多酚配位，CCDs 表现出卓越的过氧化物酶样（POD）活性，并作为一种 SAzyme 产生大量羟基自由基，导致自由基依赖性细胞周期停滞。在 GLUT 受体介导的内吞作用的帮助下，Ru/CCDs-PTX@ZIF 可触发肿瘤靶向杀伤和迁移抑制，从而抑制肿瘤的进展。这项研究为拓宽基于 CDs 的 SAzyme 在肿瘤治疗中的设计和应用开辟了一条前景广阔的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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文献相关原料

公司名称	产品信息	其他信息	采购帮参考价格
阿拉丁	dimethyl sulfoxide (DMSO)
阿拉丁	rutin
阿拉丁	tannic acid (TA)
阿拉丁	ferric chloride hexahydrate

来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.

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