Insufficient Muscle Development Level Associated with Serum Zinc, Manganese and Cobalt Levels in Children Aged 6 to 9 Years in Shenzhen, China.

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biological Trace Element Research Pub Date : 2024-11-23 DOI:10.1007/s12011-024-04458-0
Rimei Liang, Haide Zhu, Xiongcheng Cao, Yuheng Zeng, Yingbin You, Pi Guo, Qingying Zhang
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Abstract

Some trace elements have been found to be associated with muscle mass and muscle function; however, evidence in children is limited, and it remains unclear which trace elements are more relevant. We aimed to explore the association of levels of individual and combined essential trace elements and muscle development level (MDL) in young children. Muscle mass was measured by body composition analysis, and trace elements were determined by using inductively coupled plasma mass spectrometry (ICP-MS). Logistic regression, restricted cubic spline (RCS) and weighted quantile sum regression (WQS) were used to assess the individual and joint associations between trace element levels and MDL. We enrolled 2851 children: 1595 boys (55.9%) and mean age 7.1 years (range 6.8-7.3). The proportion of insufficient muscle mass in the whole body, limbs, upper and lower limbs was 1.9%, 6.5%, 44.9% and 4.6%, respectively. The odds of insufficient MDL decreased with the fourth versus first quartile of zinc (OR = 0.67, 95% CI: 0.51-0.89), manganese (OR = 0.80, 95% CI: 0.65-1.00), and cobalt (OR = 0.89, 95% CI: 0.81-0.99) and was increased with the fourth quartile of nickel (OR = 2.23, 95% CI: 1.72-2.89) and selenium (OR = 1.51, 95% CI: 1.14-1.98). The RCS yielded similar results, except for the discrepancy in high cobalt levels. The odds of insufficient MDL decreased with the combination of nine trace elements (OR = 0.84, 95% CI: 0.73-0.97), primarily zinc (weight = 0.297), manganese (weight = 0.198) and cobalt (weight = 0.173). Insufficient MDL in young children was mainly in upper limbs. Low levels of zinc, manganese, and cobalt, individually or combined, were significantly associated with risk of insufficient MDL. Further foods rich in zinc, manganese, and cobalt should be suggested to supplement in diet, and increase exercise of upper limbs to improve insufficient MDL in the young children should be needed.

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中国深圳 6 至 9 岁儿童肌肉发育不足与血清锌、锰和钴水平有关。
研究发现,一些微量元素与肌肉质量和肌肉功能有关;但是,儿童中的证据有限,而且目前仍不清楚哪些微量元素与肌肉质量和肌肉功能更相关。我们的目的是探索幼儿体内单种和综合必需微量元素水平与肌肉发育水平(MDL)之间的关系。肌肉质量通过人体成分分析法进行测量,微量元素则通过电感耦合等离子体质谱法(ICP-MS)进行测定。我们采用了逻辑回归、限制性三次样条回归(RCS)和加权量子和回归(WQS)来评估微量元素水平与MDL之间的个体关联和联合关联。我们共招募了 2851 名儿童:1595 名男孩(55.9%),平均年龄为 7.1 岁(6.8-7.3 岁不等)。全身、四肢、上肢和下肢肌肉质量不足的比例分别为 1.9%、6.5%、44.9% 和 4.6%。锌(OR = 0.67,95% CI:0.51-0.89)、锰(OR = 0.80,95% CI:0.65-1.00)和钴(OR = 0.89,95% CI:0.81-0.99)的第四四分位数与第一四分位数相比,MDL不足的几率有所下降,而镍(OR = 2.23,95% CI:1.72-2.89)和硒(OR = 1.51,95% CI:1.14-1.98)的第四四分位数则有所上升。除了钴含量高的差异外,RCS 得出了相似的结果。九种微量元素(OR = 0.84,95% CI:0.73-0.97),主要是锌(权重 = 0.297)、锰(权重 = 0.198)和钴(权重 = 0.173)的组合,导致 MDL 不足的几率下降。幼儿的 MDL 不足主要出现在上肢。锌、锰和钴的单独或合并含量低与 MDL 不足的风险显著相关。建议在饮食中补充更多富含锌、锰和钴的食物,并增加上肢运动以改善幼儿 MDL 不足的情况。
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来源期刊
Biological Trace Element Research
Biological Trace Element Research 生物-内分泌学与代谢
CiteScore
8.70
自引率
10.30%
发文量
459
审稿时长
2 months
期刊介绍: Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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