Elisabeth Brogren, Maria Andersson, Melker Westenius, Jenny Wittrup, Malin Zimmerman
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引用次数: 0
Abstract
Background: To determine whether obesity and markers of lipid metabolism are associated with radiological hand osteoarthritis (OA) in the Halland County Osteoarthritis (HALLOA) cohort.
Methods: In this cross-sectional study, we included 231 participants aged 30-65 from the HALLOA cohort, which began in 2017 and is ongoing. Hand OA was defined as ≥ 2 joint groups (distal interphalangeal, proximal interphalangeal, and carpometacarpal I) with Kellgren-Lawrence grade ≥ 2. The severity of hand OA was classified in terms of the number of affected joint groups (moderate hand OA 2-4 joint groups, severe hand OA 5-6 joint groups). Metabolic profile, including body mass index (BMI), bioimpedance, waist circumference, blood pressure, serum leptin, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides, were obtained. Multicollinearity was assessed with Pearson's correlation and associations with logistic regression analyses adjusting for age, HDL-cholesterol, and central obesity.
Results: Two-thirds of the participants were women, and 91 (39%) had hand OA. We found a relationship between LDL-cholesterol and prevalent hand OA in women with an odds ratio of 1.7 (95% CI 1.1-2.6) and an association between LDL-cholesterol and severity of hand OA in women; odds ratio for no hand OA vs. moderate hand OA was 1.6 (95% CI 1.0-2.4) and for no hand OA vs. severe hand OA 2.5 (95% CI 1.2-4.9). There were no significant relationships between hand OA and obesity or serum leptin levels.
Conclusion: Circulating LDL-cholesterol levels were associated with the prevalence and severity of hand OA in women but not men.
Trial registration: ClinicalTrials. Gov (NCT04928170), Date of registration: 2017-12-20.
背景：目的：确定哈兰德县骨关节炎（HALLOA）队列中的肥胖和脂质代谢标志物是否与放射性手部骨关节炎（OA）有关：在这项横断面研究中，我们纳入了 HALLOA 队列中 231 名 30-65 岁的参与者，该研究始于 2017 年，目前仍在进行中。手部 OA 的定义是 Kellgren-Lawrence 分级≥ 2 的关节组（远端指间关节、近端指间关节和腕掌 I）。手部 OA 的严重程度根据受影响关节组的数量进行分类（中度手部 OA 2-4 个关节组，重度手部 OA 5-6 个关节组）。代谢情况包括体重指数（BMI）、生物阻抗、腰围、血压、血清瘦素、总胆固醇、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇和甘油三酯。用皮尔逊相关性评估多重共线性，用逻辑回归分析调整年龄、高密度脂蛋白胆固醇和中心性肥胖的相关性：三分之二的参与者为女性，91人（39%）患有手部OA。我们发现低密度脂蛋白胆固醇与女性手部 OA 患病率之间存在关系，几率比为 1.7（95% CI 1.1-2.6）；低密度脂蛋白胆固醇与女性手部 OA 严重程度之间存在关系；无手部 OA 与中度手部 OA 的几率比为 1.6（95% CI 1.0-2.4），无手部 OA 与重度手部 OA 的几率比为 2.5（95% CI 1.2-4.9）。手部OA与肥胖或血清瘦素水平之间没有明显关系：结论：循环中的低密度脂蛋白胆固醇水平与女性手部OA的患病率和严重程度有关，但与男性无关：试验注册：ClinicalTrials.Gov（NCT04928170），注册日期：2017-12-20。
期刊介绍：
BMC Musculoskeletal Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of musculoskeletal disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
The scope of the Journal covers research into rheumatic diseases where the primary focus relates specifically to a component(s) of the musculoskeletal system.
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