Antibacterial and Anti-Inflammatory Activity of Chitosan Film with Rhodomyrtus Tomentosa Leaf Extract Prepared Via 3D-Printing Method.

IF 2.5 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY ChemistryOpen Pub Date : 2024-11-22 DOI:10.1002/open.202400302

Quan Vo-An, Chinh Thuy Nguyen, Uyen Thu Pham, Tuan Anh Nguyen, Duong Thanh Nguyen, Dung Tran Hoang, Lu Trong Le, Quyen Thi Cam Ngo, Hoang Thai

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Abstract

The combination of natural polymers and plant extract attracted much attention thanks to its valuable biological activities. This study presents the preparation and characterization of chitosan (CS) film containing Rhodomyrtus tomentosa leaf extract. In which, the Rhodomyrtus tomentosa leaf extract (SLE) with polyphenol-rich fractions was extracted by an ultrasonic-assisted extraction method. The prepared chitosan/polyphenol-rich fractions film (CSPPF) was characterized using infrared (IR) spectroscopy, mechanical testing, scanning electron microscopy (SEM), and water absorption analysis. Antibacterial and anti-inflammatory activities of the CSPPF were assessed using the agar well diffusion method and nitric oxide (NO) inhibition assays, respectively. Besides, the release of the extract from the CSPPF as well as the drug release kinetics was also tested. The Rhodomyrtus tomentosa leaf extract enhanced the antibacterial efficacy against Escherichia coli and enhanced the anti-inflammatory activity as well as the swelling ability of the CSPPF. The CSPPF containing 1 wt.% of SLE can inhibit 77.70 % NO with an IC₅₀ value of 19.40 μg/mL.

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通过三维打印法制备的含通心草叶提取物壳聚糖薄膜的抗菌和消炎活性

天然聚合物与植物提取物的结合因其宝贵的生物活性而备受关注。本研究介绍了含有红景天叶提取物的壳聚糖（CS）薄膜的制备和表征。研究采用超声波辅助萃取法提取了富含多酚的红景天叶提取物（SLE）。利用红外光谱、机械测试、扫描电子显微镜（SEM）和吸水率分析对制备的壳聚糖/富含多酚馏分薄膜（CSPPF）进行了表征。琼脂井扩散法和一氧化氮（NO）抑制实验分别评估了 CSPPF 的抗菌和抗炎活性。此外，还测试了 CSPPF 提取物的释放和药物释放动力学。红景天叶提取物增强了对大肠杆菌的抗菌效果，提高了 CSPPF 的抗炎活性和溶胀能力。含 1 wt.% SLE 的 CSPPF 可抑制 77.70 % 的 NO，IC50 值为 19.40 μg/mL。

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来源期刊

ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.80

自引率

4.30%

发文量

143

审稿时长

1 months

期刊介绍： ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.