Does the kidney influence the hunger for salt?

IF 14.8 1区 医学 Q1 UROLOGY & NEPHROLOGY Kidney international Pub Date : 2024-11-20 DOI:10.1016/j.kint.2024.09.009
Matthew A. Bailey
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Abstract

Sympathetic overactivation contributes to hypertension. Renal denervation can reduce blood pressure. In the deoxycorticosterone acetate (DOCA)–salt model of hypertension, salt consumption contributes to high blood pressure. A report in Kidney International finds selective ablation of renal sensory afferent nerves diminishes self-directed saline intake in the DOCA-salt rat. This suggests that these sensory nerves input to centers in the brain, amplifying salt intake. If translatable, renal denervation may have an unanticipated benefit of reducing the drive to consume salty foods in patients with poorly controlled hypertension.
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肾脏会影响对盐的饥饿感吗?
交感神经过度激活会导致高血压。肾脏去神经化可降低血压。在醋酸去氧皮质酮(DOCA)-盐高血压模型中,食盐消耗导致高血压。国际肾脏》(Kidney International)杂志上的一篇报道发现,选择性消融肾脏感觉传入神经可减少 DOCA 盐模型大鼠自主摄入的盐分。这表明,这些感觉神经输入大脑中枢,扩大了盐的摄入量。如果可以转化,肾脏神经支配可能会带来意想不到的好处,即减少控制不佳的高血压患者摄入咸食的动力。
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E. Ojo, L. Beeson, M. Deleon, Z. Cordero-MacIntyre
来源期刊
Kidney international
Kidney international 医学-泌尿学与肾脏学
CiteScore
23.30
自引率
3.10%
发文量
490
审稿时长
3-6 weeks
期刊介绍: Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.
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