Autophagy-dependent ferroptosis mediates multiple sclerosis.

Daolin Tang, Rui Kang, Daniel J Klionsky
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Abstract

A recent paper published in Cell by Woo et al. reported that autophagy-dependent ferroptosis mediated by STING1 is involved in neuronal death associated with multiple sclerosis (MS). This research broadens our understanding of the pathogenesis of MS and opens new avenues for therapeutic interventions.

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自噬依赖性铁蛋白沉积介导多发性硬化症。
Woo 等人最近在《细胞》(Cell)杂志上发表的一篇论文报告说,STING1 介导的自噬依赖性铁蛋白沉积参与了与多发性硬化症(MS)相关的神经元死亡。这项研究拓宽了我们对多发性硬化症发病机制的认识,为治疗干预开辟了新途径。
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