Association of circadian syndrome with risk of hyperuricemia among middle-aged and older adults in China: The first nationwide cohort study

IF 3.9 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Public Health Pub Date : 2024-11-23 DOI:10.1016/j.puhe.2024.10.002

Dandan Wang , Lilin Chen , Wenxing Shi , Tiantian Zhang

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Abstract

Objectives

No studies have been conducted to explore the association of circadian syndrome (CircS) and hyperuricemia. We addressed the gap by investigating the association of CircS and the risk of hyperuricemia among middle-aged and older adults in China.

Study design

Prospective cohort study.

Methods

We utilized a nationwide cohort from the China Health and Retirement Longitudinal Study, 7009 adults aged at least 45 years were enrolled at baseline in 2011, and 4415 participants followed up to 2015. CircS was assessed using seven components including five components used to define metabolic syndrome and two components of lack of sleep and depression. Multivariable logistic regression analysis was applied to examine the association of CircS and hyperuricemia. Stratified analyses were used to identify the vulnerable subgroup.

Results

Among the 7009 participants (mean age: 60.6 [SD: 9.8] years), 52.8 % were women. Compared to participants without CircS, those with CircS had a higher risk of hyperuricemia (adjusted odds ratio, aOR 2.246, 95 % CI:1.819–2.773). After 4-year follow-up, 457 (10.4 %) cases developed as hyperuricemia. The longitudinal analyses showed that CircS had a higher risk of incident hyperuricemia (aOR 2.136, 1.740–2.620). The association was stronger in women and those with kidney disease. Sensitivity analysis showed that individuals with ≥ six CircS components had the highest risk of hyperuricemia.

Conclusions

This nationwide cohort first revealed that CircS was related to an increased risk of hyperuricemia among Chinese adults. Our findings provide epidemiological evidence regarding the importance of CircS management as a preventative strategy for hyperuricemia.

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中国中老年人昼夜节律综合征与高尿酸血症风险的关系：首次全国性队列研究

研究目的目前还没有研究探讨昼夜节律综合征（CircS）与高尿酸血症的关系。为了填补这一空白，我们对中国中老年人昼夜节律综合征与高尿酸血症风险的关系进行了调查：研究设计：前瞻性队列研究：我们利用中国健康与退休纵向研究的全国性队列，于 2011 年对 7009 名年龄至少在 45 岁的成年人进行了基线登记，并对 4415 名参与者进行了随访，直至 2015 年。CircS的评估包括七个方面，其中五个方面用于定义代谢综合征，另外两个方面是睡眠不足和抑郁。采用多变量逻辑回归分析来研究 CircS 与高尿酸血症的关系。通过分层分析确定了易感亚群：在 7009 名参与者（平均年龄：60.6 [SD: 9.8]岁）中，52.8% 为女性。与未患有循环系统的参与者相比，患有循环系统的参与者患高尿酸血症的风险更高（调整后的几率比为 2.246，95 % CI：1.819-2.773）。随访 4 年后，457 例（10.4%）患者发展为高尿酸血症。纵向分析表明，CircS 患高尿酸血症的风险更高（aOR 2.136，1.740-2.620）。这种关联在女性和肾病患者中更为明显。敏感性分析表明，CircS成分≥6个的人患高尿酸血症的风险最高：这项全国性队列研究首次揭示了CircS与中国成年人患高尿酸血症的风险增加有关。我们的研究结果提供了流行病学证据，说明将CircS管理作为高尿酸血症预防策略的重要性。

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来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.