Estimation of population-specific values of theta for PowerPlex Y23 profiles

IF 3.2 2区医学 Q2 GENETICS & HEREDITY Forensic Science International-Genetics Pub Date : 2024-11-16 DOI:10.1016/j.fsigen.2024.103175

John S. Buckleton , Taryn O. Hall , Jo-Anne Bright , Michael C. Yung , Jérôme Goudet , Maarten Kruijver , Bruce S. Weir

引用次数: 0

Abstract

We examine 31,011 PPY23 profiles at the population, metapopulation and world levels. Most haplotypes appear only once but a few have higher counts, including a set of 23 matching profiles in Delhi, India and a set of 16 matching profiles in Burkina Faso with one additional matching American African profile. We estimate

F_{S T}

values to be used as “theta” (θ) in match probability calculations, following the method we used in our earlier survey of autosomal STR data. Match probability estimates using

{\hat{F}}_{S T}

or the κ method of Brenner for a previously unseen profile are similar but differ for any profile previously seen.

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PowerPlex Y23 图谱的特定人群θ值估算。

我们在种群、元种群和世界层面研究了 31011 个 PPY23 图谱。大多数单倍型只出现过一次，但也有少数单倍型出现的次数较多，包括印度德里的一组 23 个匹配型谱和布基纳法索的一组 16 个匹配型谱以及另外一个匹配的非洲裔美国人型谱。我们按照早先调查常染色体 STR 数据时使用的方法估算了 FST 值，并将其用作匹配概率计算中的 "θ"。使用 FˆST 或布伦纳（Brenner）的 κ 方法对以前未见过的特征进行的匹配概率估计是相似的，但对于以前见过的任何特征则不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Forensic Science International-Genetics 生物-医学：法

CiteScore

7.50

自引率

32.30%

发文量

132

审稿时长

11.3 weeks

期刊介绍： Forensic Science International: Genetics is the premier journal in the field of Forensic Genetics. This branch of Forensic Science can be defined as the application of genetics to human and non-human material (in the sense of a science with the purpose of studying inherited characteristics for the analysis of inter- and intra-specific variations in populations) for the resolution of legal conflicts. The scope of the journal includes: Forensic applications of human polymorphism. Testing of paternity and other family relationships, immigration cases, typing of biological stains and tissues from criminal casework, identification of human remains by DNA testing methodologies. Description of human polymorphisms of forensic interest, with special interest in DNA polymorphisms. Autosomal DNA polymorphisms, mini- and microsatellites (or short tandem repeats, STRs), single nucleotide polymorphisms (SNPs), X and Y chromosome polymorphisms, mtDNA polymorphisms, and any other type of DNA variation with potential forensic applications. Non-human DNA polymorphisms for crime scene investigation. Population genetics of human polymorphisms of forensic interest. Population data, especially from DNA polymorphisms of interest for the solution of forensic problems. DNA typing methodologies and strategies. Biostatistical methods in forensic genetics. Evaluation of DNA evidence in forensic problems (such as paternity or immigration cases, criminal casework, identification), classical and new statistical approaches. Standards in forensic genetics. Recommendations of regulatory bodies concerning methods, markers, interpretation or strategies or proposals for procedural or technical standards. Quality control. Quality control and quality assurance strategies, proficiency testing for DNA typing methodologies. Criminal DNA databases. Technical, legal and statistical issues. General ethical and legal issues related to forensic genetics.