Antibacterial efficacy of nanoparticles on orthodontic materials—A systematic review and meta-analysis

IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE International Orthodontics Pub Date : 2024-11-25 DOI:10.1016/j.ortho.2024.100955

Dhruv Ahuja, Ashish Kumar Singh, Puneet Batra

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Abstract

Aim

This study aims to evaluate the efficacy of coated nanoparticles within orthodontic appliances as a novel strategy to enhance their antibacterial properties.

Material and methods

A systematic search for relevant articles published between 2013 and March 2024 was conducted across electronic databases including PubMed, Scopus, Web of Science, and EBSCOhost. Studies meeting pre-defined eligibility criteria were included and assessed for methodological quality. Data on the antibacterial activity of coated nanoparticles on orthodontic appliances was extracted from included studies.

Results

A range of antimicrobial agents, including metallic nanoparticles (silver, titanium dioxide, silver-platinum alloy, zinc oxide, copper oxide), and others like chitosan, quaternary ammonium-modified gold nanoclusters, titanium nitride doped with calcium phosphate, and graphene oxide, have been explored for incorporation into orthodontic materials. Studies have shown a significant boost in the antibacterial capacity of these materials compared to controls, suggesting promise for improved oral hygiene during orthodontic treatment.

Conclusion

It can be concluded that incorporating nanoparticles into orthodontic appliances holds promise for enhancing their antibacterial properties. However, the studies displayed significant heterogeneity therefore, further research with standardized protocols for factors like nanoparticle size, concentration, and incorporation techniques across various orthodontic materials is crucial to guide future clinical applications.

Prospero registration

CRD42024521326.

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纳米粒子对正畸材料的抗菌功效--系统综述和荟萃分析

材料和方法通过电子数据库（包括 PubMed、Scopus、Web of Science 和 EBSCOhost）对 2013 年至 2024 年 3 月间发表的相关文章进行了系统检索。符合预设资格标准的研究均被纳入，并进行了方法学质量评估。结果一系列抗菌剂，包括金属纳米粒子（银、二氧化钛、银铂合金、氧化锌、氧化铜），以及壳聚糖、季铵盐改性金纳米团簇、掺杂磷酸钙的氮化钛和氧化石墨烯等其他抗菌剂，已被探索用于正畸材料中。研究表明，与对照组相比，这些材料的抗菌能力明显增强，这表明在正畸治疗期间有望改善口腔卫生。然而，这些研究显示出明显的异质性，因此，进一步研究各种正畸材料中纳米粒子的大小、浓度和加入技术等因素的标准化方案对于指导未来的临床应用至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Orthodontics DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

2.50

自引率

13.30%

发文量

审稿时长

26 days

期刊介绍： Une revue de référence dans le domaine de orthodontie et des disciplines frontières Your reference in dentofacial orthopedics International Orthodontics adresse aux orthodontistes, aux dentistes, aux stomatologistes, aux chirurgiens maxillo-faciaux et aux plasticiens de la face, ainsi quà leurs assistant(e)s. International Orthodontics is addressed to orthodontists, dentists, stomatologists, maxillofacial surgeons and facial plastic surgeons, as well as their assistants.