{"title":"Single/dual/multi-responsive fluorescent probes for multiple analytes in mitophagy: A review","authors":"Sha Li, Zhiying Li, Miao Yan, Haixian Ren","doi":"10.1016/j.dyepig.2024.112545","DOIUrl":null,"url":null,"abstract":"<div><div>As the \"power stations\" of the cell, mitochondria are involved in many energy metabolism processes. Abnormalities in mitochondrial structure and function (mitophagy) can affect the activity of living cells and lead to disease. Visualizing the concentration changes in the relevant analytes in real time is essential to better understand the visualization of mitophagy processes. Several probes have been reported for the detection of one or more analytes in mitochondria. However, topic has not been summarized. Therefore, it is very important to explore the latest progress of small molecule fluorescent probes in this emerging field. Based on the role of analytes in mitochondrial autophagy, this reviews recent advances in single/double/multi-responsive fluorescent probes with specific recognition function and selective signal conversion of mitochondrial autophagy related analytes (including pH, viscosity, polarity, hypoxia, and mitochondrial ROS RSS fluctuations) since 2016. We believe that this review will be of wide interest to scientists engaged in research related to mitochondrial autophagy and provide valuable insights to chemists, biologists and medical researchers to contribute to the diagnosis and treatment of related diseases.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"234 ","pages":"Article 112545"},"PeriodicalIF":4.1000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dyes and Pigments","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0143720824006119","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
As the "power stations" of the cell, mitochondria are involved in many energy metabolism processes. Abnormalities in mitochondrial structure and function (mitophagy) can affect the activity of living cells and lead to disease. Visualizing the concentration changes in the relevant analytes in real time is essential to better understand the visualization of mitophagy processes. Several probes have been reported for the detection of one or more analytes in mitochondria. However, topic has not been summarized. Therefore, it is very important to explore the latest progress of small molecule fluorescent probes in this emerging field. Based on the role of analytes in mitochondrial autophagy, this reviews recent advances in single/double/multi-responsive fluorescent probes with specific recognition function and selective signal conversion of mitochondrial autophagy related analytes (including pH, viscosity, polarity, hypoxia, and mitochondrial ROS RSS fluctuations) since 2016. We believe that this review will be of wide interest to scientists engaged in research related to mitochondrial autophagy and provide valuable insights to chemists, biologists and medical researchers to contribute to the diagnosis and treatment of related diseases.
期刊介绍：
Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied.
Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media.
The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.
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