Protein data bank: From two epidemics to the global pandemic to mRNA vaccines and Paxlovid

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Current opinion in structural biology Pub Date : 2024-11-24 DOI:10.1016/j.sbi.2024.102954

Stephen K. Burley

引用次数: 0

Abstract

Structural biologists and the open-access Protein Data Bank (PDB) played decisive roles in combating the COVID-19 pandemic. Global biostructure data were turned into global knowledge, allowing scientists and engineers to understand the inner workings of coronaviruses and develop effective countermeasures. Two mRNA vaccines, initially designed with guidance from PDB structures of the SARS-CoV-1 and MERS-CoV spike proteins, prevented infections entirely or reduced the likelihood of morbidity and mortality for more than five billion individual recipients worldwide. Structure-guided drug discovery by Pfizer, Inc (facilitated by PDB structures), initiated in the 2000s in response to SARS-CoV-1 and resumed in 2020, yielded nirmatrelvir (the active ingredient of Paxlovid) -- a potent, orally-bioavailable inhibitor of the SARS-CoV-2 main protease. You've got to love the Protein Data Bank!

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蛋白质数据库：从两次流行病到全球大流行，再到 mRNA 疫苗和 Paxlovid

结构生物学家和开放式蛋白质数据库（PDB）在抗击 COVID-19 大流行中发挥了决定性作用。全球生物结构数据被转化为全球知识，使科学家和工程师能够了解冠状病毒的内部运作，并开发出有效的应对措施。最初根据 SARS-CoV-1 和 MERS-CoV 尖峰蛋白的 PDB 结构指导设计的两种 mRNA 疫苗，为全球 50 多亿受试者完全防止了感染或降低了发病和死亡的可能性。辉瑞公司（Pfizer, Inc）于 2000 年代针对 SARS-CoV-1 启动了以结构为导向的药物研发（PDB 结构为研发提供了便利），并于 2020 年重新启动，研发出了 nirmatrelvir（Paxlovid 的活性成分）--一种强效的 SARS-CoV-2 主要蛋白酶口服生物抑制剂。你一定会爱上蛋白质数据库！

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in structural biology 生物-生化与分子生物学

CiteScore

12.20

自引率

2.90%

发文量

179

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Structural Biology (COSB) aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In COSB, we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. [...] The subject of Structural Biology is divided into twelve themed sections, each of which is reviewed once a year. Each issue contains two sections, and the amount of space devoted to each section is related to its importance. -Folding and Binding- Nucleic acids and their protein complexes- Macromolecular Machines- Theory and Simulation- Sequences and Topology- New constructs and expression of proteins- Membranes- Engineering and Design- Carbohydrate-protein interactions and glycosylation- Biophysical and molecular biological methods- Multi-protein assemblies in signalling- Catalysis and Regulation

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