White matter differences between younger and older adults revealed by fixel-based analysis

IF 1.7 Q3 CLINICAL NEUROLOGY Aging brain Pub Date : 2024-01-01 DOI:10.1016/j.nbas.2024.100132
Feliberto de la Cruz , Andy Schumann , Katrin Rieger , Daniel Güllmar , Jürgen R. Reichenbach , Karl-Jürgen Bär
{"title":"White matter differences between younger and older adults revealed by fixel-based analysis","authors":"Feliberto de la Cruz ,&nbsp;Andy Schumann ,&nbsp;Katrin Rieger ,&nbsp;Daniel Güllmar ,&nbsp;Jürgen R. Reichenbach ,&nbsp;Karl-Jürgen Bär","doi":"10.1016/j.nbas.2024.100132","DOIUrl":null,"url":null,"abstract":"<div><div>The process of healthy aging involves complex alterations in neural structures, with white matter (WM) changes significantly impacting cognitive and motor functions. Conventional methods such as diffusion tensor imaging provide valuable insights, but their limitations in capturing complex WM geometry advocate for more advanced approaches. In this study involving 120 healthy volunteers, we investigated whole-brain WM differences between young and old individuals using a novel technique called fixel-based analysis (FBA). This approach revealed that older adults exhibited reduced FBA-derived metrics in several WM tracts, with frontal areas particularly affected. Surprisingly, age-related differences in FBA-derived measures showed no significant correlation with risk factors such as alcohol consumption, exercise frequency, or pulse pressure but predicted cognitive performance. These findings emphasize FBA’s potential in characterizing complex WM changes and the link between cognitive abilities and WM alterations in healthy aging. Overall, this study advances our understanding of age-related neurodegeneration, highlighting the importance of comprehensive assessments that integrate advanced neuroimaging techniques, cognitive evaluation, and demographic factors to gain insights into healthy aging.</div></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"6 ","pages":"Article 100132"},"PeriodicalIF":1.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging brain","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589958924000288","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

The process of healthy aging involves complex alterations in neural structures, with white matter (WM) changes significantly impacting cognitive and motor functions. Conventional methods such as diffusion tensor imaging provide valuable insights, but their limitations in capturing complex WM geometry advocate for more advanced approaches. In this study involving 120 healthy volunteers, we investigated whole-brain WM differences between young and old individuals using a novel technique called fixel-based analysis (FBA). This approach revealed that older adults exhibited reduced FBA-derived metrics in several WM tracts, with frontal areas particularly affected. Surprisingly, age-related differences in FBA-derived measures showed no significant correlation with risk factors such as alcohol consumption, exercise frequency, or pulse pressure but predicted cognitive performance. These findings emphasize FBA’s potential in characterizing complex WM changes and the link between cognitive abilities and WM alterations in healthy aging. Overall, this study advances our understanding of age-related neurodegeneration, highlighting the importance of comprehensive assessments that integrate advanced neuroimaging techniques, cognitive evaluation, and demographic factors to gain insights into healthy aging.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
基于固定颗粒的分析揭示了年轻人和老年人的白质差异
健康老龄化过程涉及神经结构的复杂变化,其中白质(WM)的变化对认知和运动功能有重大影响。扩散张量成像等传统方法能提供有价值的见解,但它们在捕捉复杂的 WM 几何结构方面存在局限性,因此需要更先进的方法。在这项涉及 120 名健康志愿者的研究中,我们使用一种名为 "基于定点的分析"(FBA)的新技术,研究了年轻人和老年人之间的全脑 WM 差异。这种方法显示,老年人在多个 WM 束中表现出 FBA 衍生指标的减少,额叶区域尤其受到影响。令人惊讶的是,FBA衍生指标中与年龄相关的差异与饮酒、运动频率或脉压等风险因素没有显著相关性,但却能预测认知表现。这些发现强调了 FBA 在描述复杂的 WM 变化方面的潜力,以及在健康老龄化过程中认知能力与 WM 变化之间的联系。总之,这项研究加深了我们对与年龄相关的神经退行性变的理解,强调了综合评估的重要性,即整合先进的神经影像技术、认知评估和人口因素,以深入了解健康老龄化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
自引率
0.00%
发文量
0
期刊最新文献
TOMM40 may mediate GFAP, neurofilament light Protein, pTau181, and brain morphometry in aging. Sleep-memory relationships during brain aging. Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making Age-related decline in social interaction is associated with decreased c-Fos induction in select brain regions independent of oxytocin receptor expression profiles
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1