A Glimpse for the subsistence from pandemic SARS-CoV-2 infection

IF 4.5 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Bioorganic Chemistry Pub Date : 2024-11-22 DOI:10.1016/j.bioorg.2024.107977

Santosh K. Rath , Ashutosh K. Dash , Nandan Sarkar , Mitali Panchpuri

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Abstract

COVID-19 is an emerging viral pandemic caused by SARS-CoV-2, which is the causative agent of unprecedented disease-causing public health threats globally. Worldwide, this outbreak is wreaking havoc due to failure in risk assessment regarding the urgency of the pandemic. As per the reports, many secondary complications which include neurological, nephrological, gastrointestinal, cardiovascular, immune, and hepatic abnormalities, are linked with COVID −19 infection which is associated with prominent respiratory disorders including pneumonia. Hindering the initial binding of the virus with Angiotensin-converting enzyme 2 (ACE2) through the spike protein is one potential boulevard of monoclonal antibodies. Although some drug regimens and vaccines have shown safety in trials, none have been entirely successful yet.

This review highlights, some of the potential antibodies (tocilizumab, Sarilumab, Avdoralimab, Lenzilumab, Interferon (alfa /beta /gamma)) screened against SARS-CoV-2 and the most promising drugs (Favipiravir, Hydroxychloroquine, Niclosamide, Ribavirin, Baricitinib, Remdesivir, Arbidol Losartan, Ritonavir, Lopinavir, Baloxavir, Nitazoxanide, Camostat) in various stages of development with their synthetic protocol and their clinical projects are discussed to counter COVID −19.

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从 SARS-CoV-2 感染大流行中窥探生存之道

COVID-19 是由 SARS-CoV-2 引起的一种新出现的病毒性大流行病，它是在全球范围内造成前所未有的致病性公共卫生威胁的病原体。由于未能对这一流行病的紧迫性进行风险评估，这一疫情正在全球范围内造成严重破坏。根据报告，许多继发性并发症，包括神经、肾、胃肠、心血管、免疫和肝功能异常，都与 COVID -19 感染有关，而 COVID -19 感染与包括肺炎在内的严重呼吸系统疾病有关。通过尖峰蛋白阻碍病毒与血管紧张素转换酶 2（ACE2）的初始结合是单克隆抗体的一个潜在途径。尽管一些药物疗法和疫苗在试验中显示出了安全性，但还没有一种疗法是完全成功的。本综述重点介绍了针对 SARS-CoV-2 筛选出的一些潜在抗体（tocilizumab、Sarilumab、Avdoralimab、Lenzilumab、干扰素（α/β/γ））和最有前景的药物（Favipiravir、羟氯喹、尼可刹米、利巴韦林、巴利昔单抗）、为应对 COVID-19，讨论了处于不同开发阶段的药物（法维拉韦、羟氯喹、尼可刹米、利巴韦林、巴利替尼、雷米地韦、阿比多洛沙坦、利托那韦、洛匹那韦、巴洛沙韦、尼他唑沙内酯、卡莫司他）及其合成方案和临床项目。

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来源期刊

Bioorganic Chemistry 生物-生化与分子生物学

CiteScore

9.70

自引率

3.90%

发文量

679

审稿时长

31 days

期刊介绍： Bioorganic Chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. The scope of the journal covers a range of topics at the organic chemistry-biology interface, including: enzyme catalysis, biotransformation and enzyme inhibition; nucleic acids chemistry; medicinal chemistry; natural product chemistry, natural product synthesis and natural product biosynthesis; antimicrobial agents; lipid and peptide chemistry; biophysical chemistry; biological probes; bio-orthogonal chemistry and biomimetic chemistry. For manuscripts dealing with synthetic bioactive compounds, the Journal requires that the molecular target of the compounds described must be known, and must be demonstrated experimentally in the manuscript. For studies involving natural products, if the molecular target is unknown, some data beyond simple cell-based toxicity studies to provide insight into the mechanism of action is required. Studies supported by molecular docking are welcome, but must be supported by experimental data. The Journal does not consider manuscripts that are purely theoretical or computational in nature. The Journal publishes regular articles, short communications and reviews. Reviews are normally invited by Editors or Editorial Board members. Authors of unsolicited reviews should first contact an Editor or Editorial Board member to determine whether the proposed article is within the scope of the Journal.