Thi Tu Oanh Nguyen , Thi Minh Hang Nguyen , Mai Thao Vu , Yohan Seo , SeonJu Park , Van Cuong Pham , Van Hung Nguyen , Xuan Nhiem Nguyen
{"title":"A new furanoditerpene from Saururus chinensis aerial parts","authors":"Thi Tu Oanh Nguyen , Thi Minh Hang Nguyen , Mai Thao Vu , Yohan Seo , SeonJu Park , Van Cuong Pham , Van Hung Nguyen , Xuan Nhiem Nguyen","doi":"10.1016/j.phytol.2024.11.009","DOIUrl":null,"url":null,"abstract":"<div><div>A new furanoditerpene, saurufuranol (<strong>1</strong>) along with a flavonoid, 3,5,7,3′,4′-pentamethoxyflavone (<strong>2</strong>), and eight lignans including macelignan (<strong>3</strong>), 5-((2<em>R</em>,3<em>R</em>)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl)benzo[<em>d</em>][1,3]dioxole (<strong>4</strong>), dihydroguaiaretic acid (<strong>5</strong>), <strong>(+)-</strong>zuonin A (<strong>6</strong>), sauchinone (<strong>7</strong>), saucerneol A (<strong>8</strong>), manassantin A (<strong>9</strong>) and saucerneol C (<strong>10</strong>). Their structures were determined by extensive spectroscopic studies using NMR spectroscopy and mass spectrometry in combination with literature. These compounds were evaluated cytotoxicity on PC-9 and HT-29 cancer cell line. Compound <strong>8</strong> showed significant activity on both of cancer cell lines with IC<sub>50</sub> values of 1.33±0.23 and 1.18±0.27 µM, respectively.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"65 ","pages":"Pages 24-27"},"PeriodicalIF":1.3000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024001587","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
A new furanoditerpene, saurufuranol (1) along with a flavonoid, 3,5,7,3′,4′-pentamethoxyflavone (2), and eight lignans including macelignan (3), 5-((2R,3R)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl)benzo[d][1,3]dioxole (4), dihydroguaiaretic acid (5), (+)-zuonin A (6), sauchinone (7), saucerneol A (8), manassantin A (9) and saucerneol C (10). Their structures were determined by extensive spectroscopic studies using NMR spectroscopy and mass spectrometry in combination with literature. These compounds were evaluated cytotoxicity on PC-9 and HT-29 cancer cell line. Compound 8 showed significant activity on both of cancer cell lines with IC50 values of 1.33±0.23 and 1.18±0.27 µM, respectively.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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